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- W4387361608 endingPage "12" @default.
- W4387361608 startingPage "1" @default.
- W4387361608 abstract "Advances in genomics have facilitated the application of cell-free DNA (cfDNA) and circulating tumor DNA (ctDNA) in phase II and phase III clinical trials. The various mutations of cfDNA/ctDNA have been correlated with clinical features. Advances in next-generation sequencing (NGS) and digital droplet PCR have paved the way for identifying cfDNA/ctDNA mutations.Herein, the biology of ctDNA and its function in clinical application in metastasis, which may lead to improved clinical management of metastatic cancer patients, are comprehensively reviewed.Metastatic cancer ctDNA shows the greatest frequency of mutations in TP53, HER-2, KRAS, and EGFR genes (alteration frequency of > 50%). Therefore, identifying key mutations frequently present in metastatic cancers can help identify patients with pre-malignant tumors before cancer progression. Studying ctDNA can help determine the prognosis and select appropriate treatments for affected patients. Nevertheless, the obstacles to detecting and analyzing ctDNA should be addressed before translation into routine practice. Also, more clinical trials should be conducted to study the significance of ctDNA in commonly diagnosed malignancies. Given the recent advances in personalized anti-neoplastic treatments, further studies are needed to detect a panel of ctDNA and patient-specific ctDNA for various cancers." @default.
- W4387361608 created "2023-10-06" @default.
- W4387361608 creator A5003425092 @default.
- W4387361608 creator A5021281252 @default.
- W4387361608 creator A5045023967 @default.
- W4387361608 date "2023-10-05" @default.
- W4387361608 modified "2023-10-15" @default.
- W4387361608 title "Clinical application of circulating tumor DNA in metastatic cancers" @default.
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