FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387362013> ?p ?o ?g. }

• W4387362013 abstract "Abstract Disclosure: O.C. Reyes: None. A. Sison: None. M. Villa: None. D. Dimayuga: None. Introduction: Adrenocorticotropic hormone-producing pancreatic neuroendocrine neoplasm (ACTHoma) is a rare type of pancreatic neuroendocrine tumor that causes ectopic adrenocorticotropic hormone syndrome. Cushingoid manifestations and metabolic abnormalities can occur rapidly. High index of suspicion is required for early diagnosis. Case: A 31-year-old Filipino female presented with facial and ankle swelling that occurred 6 weeks before the visit. She also had acne, easy bruising, amenorrhea and frequent mood swings. There was reported weight gain of 3 kg a month prior. She had no history of hypertension and diabetes, and had no unusual family history. At the time of admission, vital signs were blood pressure of 130/80mmHg, pulse of 92/min, respiratory rate 20/min and body temperature of 37.2C. Her body mass index was 28kg/m2. She had muscle atrophy of the upper and lower extremities, facial flushing, posterior cervical fat pad, abdominal violaceous striae, and skin pigmentation. Her external genitalia was normal, Tanner Stage 5 consistent with adult pattern. Neurologic exam was unremarkable. She was examined for Cushing’s syndrome. On initial tests, glucose was 406 mg/dl, HbA1C 10.7%, thyroid stimulating hormone 0.122 (NV: 0.55-4.78), Free T3 0.77 (NV: 2.3-4.2), Free T4 0.58 (NV: 0.89-1.76). Creatinine was 0.86 mg/dL, sodium was 140 mEq/L, potassium was 2.1 mEq/L showing hypokalemia. There was leukocytosis on her blood count, white blood cells 15,310/mm3 (neutrophils 94%, lymphocytes 3%). In the low-dose dexamethasone suppression test (DST), the serum cortisol concentration was 991.03nmol/L. Her adrenocorticotrophic hormone (ACTH) level was elevated at 577pg/mL. After high-dose DST, the serum cortisol concentration was &gt; 1750 nmol/L. No tumor was observed on pituitary magnetic resonance imaging. On abdominal computed tomography (CT), a large, lobulated, heterogeneously-enhancing mass arising from the pancreatic body and tail measuring 7.5cm x 10cm x 10.9cm was seen. The mass had infiltrated the gastric fundus, and encased the splenic artery. Multiple non-calcified subcentimeter pulmonary nodules were observed on chest CT. CT-guided biopsy of the pancreatic mass was done. On microscopic examination, numerous atypical cells arranged with small clusters and sheets and scattered singly were found in the tumor. The cells had small to enlarged, hyperchromatic, ovoid to round nuclei and scant to ample delicate cytoplasm. On immunohistochemical staining, the tumor cells were stained positive for synaptophysin and chromogranin A, which are both neuroendocrine markers, as well as ACTH. However, the patient died prior to any definitive management. Conclusion: ACTHoma is a very rare disease that causes hypercortisolemia. Reporting of similar cases will provide insight into its clinical features, immunohistochemical characteristics, diagnosis, therapy, and prognosis. Presentation: Thursday, June 15, 2023" @default.
• W4387362013 created "2023-10-06" @default.
• W4387362013 creator A5008537727 @default.
• W4387362013 creator A5032630973 @default.
• W4387362013 creator A5039641842 @default.
• W4387362013 creator A5075694189 @default.
• W4387362013 date "2023-10-01" @default.
• W4387362013 modified "2023-10-06" @default.
• W4387362013 title "THU517 Aggressive Cushing’s: A Rare Case Of Pancreatic ACTHoma In A Young Female" @default.
• W4387362013 doi "https://doi.org/10.1210/jendso/bvad114.2145" @default.
• W4387362013 hasPublicationYear "2023" @default.
• W4387362013 type Work @default.
• W4387362013 citedByCount "0" @default.
• W4387362013 crossrefType "journal-article" @default.
• W4387362013 hasAuthorship W4387362013A5008537727 @default.
• W4387362013 hasAuthorship W4387362013A5032630973 @default.
• W4387362013 hasAuthorship W4387362013A5039641842 @default.
• W4387362013 hasAuthorship W4387362013A5075694189 @default.
• W4387362013 hasBestOaLocation W43873620131 @default.
• W4387362013 hasConcept C126322002 @default.
• W4387362013 hasConcept C134018914 @default.
• W4387362013 hasConcept C141071460 @default.
• W4387362013 hasConcept C2776376844 @default.
• W4387362013 hasConcept C2778242168 @default.
• W4387362013 hasConcept C2780546910 @default.
• W4387362013 hasConcept C2909029107 @default.
• W4387362013 hasConcept C71315377 @default.
• W4387362013 hasConcept C71924100 @default.
• W4387362013 hasConcept C90924648 @default.
• W4387362013 hasConceptScore W4387362013C126322002 @default.
• W4387362013 hasConceptScore W4387362013C134018914 @default.
• W4387362013 hasConceptScore W4387362013C141071460 @default.
• W4387362013 hasConceptScore W4387362013C2776376844 @default.
• W4387362013 hasConceptScore W4387362013C2778242168 @default.
• W4387362013 hasConceptScore W4387362013C2780546910 @default.
• W4387362013 hasConceptScore W4387362013C2909029107 @default.
• W4387362013 hasConceptScore W4387362013C71315377 @default.
• W4387362013 hasConceptScore W4387362013C71924100 @default.
• W4387362013 hasConceptScore W4387362013C90924648 @default.
• W4387362013 hasIssue "Supplement_1" @default.
• W4387362013 hasLocation W43873620131 @default.
• W4387362013 hasOpenAccess W4387362013 @default.
• W4387362013 hasPrimaryLocation W43873620131 @default.
• W4387362013 hasRelatedWork W198499382 @default.
• W4387362013 hasRelatedWork W2004060098 @default.
• W4387362013 hasRelatedWork W2060267162 @default.
• W4387362013 hasRelatedWork W2060408085 @default.
• W4387362013 hasRelatedWork W2076837851 @default.
• W4387362013 hasRelatedWork W2158004491 @default.
• W4387362013 hasRelatedWork W2413209925 @default.
• W4387362013 hasRelatedWork W2726071270 @default.
• W4387362013 hasRelatedWork W2947785203 @default.
• W4387362013 hasRelatedWork W3011810233 @default.
• W4387362013 hasVolume "7" @default.
• W4387362013 isParatext "false" @default.
• W4387362013 isRetracted "false" @default.
• W4387362013 workType "article" @default.