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- W4387362806 abstract "Mechanism underlying the metabolic benefit of intermittent fasting remains largely unknown. Here, we reported that intermittent fasting promoted IL-22 production by ILC3s and subsequent beigeing of subcutaneous white adipose tissue. Adoptive transfer of intestinal ILC3s increased beigeing of white adipose tissue in diet-induced-obese mice. Exogenous IL-22 significantly increased the beigeing of subcutaneous white adipose tissue. Deficiency of IL-22 receptor attenuated the beigeing induced by intermittent fasting. Single-cell sequencing of sorted intestinal immune cells revealed that intermittent fasting increased aryl hydrocarbon receptor signaling in ILC3s. Analysis of cell‒cell ligand receptor interactions indicated that intermittent fasting may stimulate the interaction of ILC3s with dendritic cells (DCs) and macrophages. These results establish the role of intestinal ILC3s in beigeing of white adipose tissue, suggesting that ILC3/IL-22/IL-22R axis contributes to the metabolic benefit of intermittent fasting." @default.
- W4387362806 created "2023-10-06" @default.
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- W4387362806 date "2023-10-05" @default.
- W4387362806 modified "2023-10-06" @default.
- W4387362806 title "Intermittent fasting promotes ILC3s secreting IL-22 contributing to the beigeing of white adipose tissue" @default.
- W4387362806 doi "https://doi.org/10.7554/elife.91060" @default.
- W4387362806 hasPublicationYear "2023" @default.
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