Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387364105> ?p ?o ?g. }
- W4387364105 endingPage "123487" @default.
- W4387364105 startingPage "123487" @default.
- W4387364105 abstract "This study aims to develop a pharmaceutical formulation that combines the potent antibacterial effect of lincomycin and lauric acid against Cutibacterium acnes (C. acnes), a bacterium implicated in acne. The selection of lauric acid was based on an in silico study, which suggested that its interaction with specific protein targets of C. acnes may contribute to its synergistic antibacterial and anti-inflammatory effects. To achieve our aim, glycerosomes were fabricated with the incorporation of lauric acid as a main constituent of glycerosomes vesicular membrane along with cholesterol and phospholipon 90H, while lincomycin was entrapped within the aqueous cavities. Glycerol is expected to enhance the cutaneous absorption of the active moieties via hydrating the skin. Optimization of lincomycin-loaded glycerosomes (LM-GSs) was conducted using a mixed factorial experimental design. The optimized formulation; LM-GS4 composed of equal ratios of cholesterol:phospholipon90H:Lauric acid, demonstrated a size of 490±17.5 nm, entrapment efficiency-values of 90±1.4% for lincomycin, and 97±0.2% for lauric acid, and a surface charge of -30.2±0.5mV. To facilitate its application on the skin, the optimized formulation was incorporated into a carbopol hydrogel. The formed hydrogel exhibited a pH value of 5.95±0.03 characteristic of pH-balanced skincare and a shear-thinning non-Newtonian pseudoplastic flow. Skin deposition of lincomycin was assessed using an in-house developed and validated LC-MS/MS method employing gradient elution and electrospray ionization. Results revealed that LM-GS4 hydrogel exhibited a two-fold increase in skin deposition of lincomycin compared to lincomycin hydrogel, indicating improved skin penetration and sustained release. The synergistic healing effect of LM-GS4 was evidenced by a reduction in inflammation, bacterial load, and improved histopathological changes in an acne mouse model. In conclusion, the proposed formulation demonstrated promising potential as a topical treatment for acne. It effectively enhanced the cutaneous absorption of lincomycin, exhibited favorable physical properties, and synergistic antibacterial and healing effects. This study provides valuable insights for the development of an effective therapeutic approach for acne management." @default.
- W4387364105 created "2023-10-06" @default.
- W4387364105 creator A5002478658 @default.
- W4387364105 creator A5010673741 @default.
- W4387364105 creator A5014326641 @default.
- W4387364105 creator A5014451119 @default.
- W4387364105 creator A5051085042 @default.
- W4387364105 creator A5093007671 @default.
- W4387364105 date "2023-11-01" @default.
- W4387364105 modified "2023-10-15" @default.
- W4387364105 title "Synergistic Approach for Acne Vulgaris Treatment using Glycerosomes Loaded with Lincomycin and Lauric Acid: Formulation, In Silico, In Vitro, LC-MS/MS Skin Deposition Assay and In Vivo Evaluation" @default.
- W4387364105 cites W1209973214 @default.
- W4387364105 cites W1473982830 @default.
- W4387364105 cites W1510413135 @default.
- W4387364105 cites W1539067843 @default.
- W4387364105 cites W1912444428 @default.
- W4387364105 cites W1965659086 @default.
- W4387364105 cites W1968271400 @default.
- W4387364105 cites W1969722179 @default.
- W4387364105 cites W1978401291 @default.
- W4387364105 cites W1981927278 @default.
- W4387364105 cites W1989357221 @default.
- W4387364105 cites W1996054695 @default.
- W4387364105 cites W2000976871 @default.
- W4387364105 cites W2001682416 @default.
- W4387364105 cites W2005595444 @default.
- W4387364105 cites W2020882358 @default.
- W4387364105 cites W2022436829 @default.
- W4387364105 cites W2030865354 @default.
- W4387364105 cites W2033571882 @default.
- W4387364105 cites W2034750464 @default.
- W4387364105 cites W2039685150 @default.
- W4387364105 cites W2040221200 @default.
- W4387364105 cites W2044500001 @default.
- W4387364105 cites W2056045451 @default.
- W4387364105 cites W2058499720 @default.
- W4387364105 cites W2062906923 @default.
- W4387364105 cites W2064776678 @default.
- W4387364105 cites W2073668315 @default.
- W4387364105 cites W2084889518 @default.
- W4387364105 cites W2085637276 @default.
- W4387364105 cites W2086420167 @default.
- W4387364105 cites W2102432127 @default.
- W4387364105 cites W2103497341 @default.
- W4387364105 cites W2106531760 @default.
- W4387364105 cites W2108338264 @default.
- W4387364105 cites W2116385303 @default.
- W4387364105 cites W2119177700 @default.
- W4387364105 cites W2133051117 @default.
- W4387364105 cites W2153829912 @default.
- W4387364105 cites W2172020371 @default.
- W4387364105 cites W2186595494 @default.
- W4387364105 cites W2236556070 @default.
- W4387364105 cites W2298257878 @default.
- W4387364105 cites W2300942687 @default.
- W4387364105 cites W2461561501 @default.
- W4387364105 cites W2468681209 @default.
- W4387364105 cites W2470890763 @default.
- W4387364105 cites W2487548740 @default.
- W4387364105 cites W2513169147 @default.
- W4387364105 cites W2524986678 @default.
- W4387364105 cites W2535932869 @default.
- W4387364105 cites W2587729310 @default.
- W4387364105 cites W2611657831 @default.
- W4387364105 cites W2615544879 @default.
- W4387364105 cites W2737114188 @default.
- W4387364105 cites W2765238798 @default.
- W4387364105 cites W2794768171 @default.
- W4387364105 cites W2855412943 @default.
- W4387364105 cites W2884200079 @default.
- W4387364105 cites W2888924355 @default.
- W4387364105 cites W2893487340 @default.
- W4387364105 cites W2894600657 @default.
- W4387364105 cites W2904809476 @default.
- W4387364105 cites W2971163412 @default.
- W4387364105 cites W2986307968 @default.
- W4387364105 cites W2993922592 @default.
- W4387364105 cites W3015889089 @default.
- W4387364105 cites W3048085533 @default.
- W4387364105 cites W3090904995 @default.
- W4387364105 cites W3091501367 @default.
- W4387364105 cites W3092343335 @default.
- W4387364105 cites W3096857144 @default.
- W4387364105 cites W3108776821 @default.
- W4387364105 cites W3109414540 @default.
- W4387364105 cites W3112658832 @default.
- W4387364105 cites W3120006517 @default.
- W4387364105 cites W3127726407 @default.
- W4387364105 cites W3155632085 @default.
- W4387364105 cites W4200519668 @default.
- W4387364105 cites W4210787551 @default.
- W4387364105 cites W4220867756 @default.
- W4387364105 cites W4296482746 @default.
- W4387364105 cites W4304013976 @default.
- W4387364105 cites W4306709139 @default.
- W4387364105 cites W4319317030 @default.
- W4387364105 cites W4386226864 @default.
- W4387364105 doi "https://doi.org/10.1016/j.ijpharm.2023.123487" @default.