Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387364325> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W4387364325 endingPage "2708" @default.
- W4387364325 startingPage "2708" @default.
- W4387364325 abstract "Although obese sarcopenia is a major public health problem with increasing prevalence worldwide, the factors that contribute to the development of obese sarcopenia are still obscure. In order to clarify this issue, a high-fat-diet-induced obese sarcopenia mouse model was utilized. After being fed with a high-fat diet for 24 weeks, decreased motor functions and muscle mass ratios were found in the C57BL/6 mice. In addition, the expression of calsarcin-2 was significantly increased in their skeletal muscle, which was determined by a microarray analysis. In order to clarify the role of calsarcin-2 in muscle, lentiviral vectors containing the calsarcin-2 gene or short hairpin RNA targeted to calsarcin-2 were used to manipulate calsarcin-2 expressions in L6 myoblasts. We found that an overexpression of calsarcin-2 facilitated L6 myoblast differentiation, whereas a calsarcin-2 knockdown delayed myoblast differentiation, as determined by the expression of myogenin. However, the calsarcin-2 knockdown showed no significant effects on myoblast proliferation. In addition, to clarify the relationship between serum calsarcin-2 and sarcopenia, the bilateral gastrocnemius muscle mass per body weight in mice and appendicular skeletal muscle mass index in humans were measured. Although calsarcin-2 facilitated myoblast differentiation, the serum calsarcin-2 concentration was negatively related to skeletal muscle mass index in mice and human subjects. Taken together, calsarcin-2 might facilitate myoblast differentiation and appear to play a compensatory role in sarcopenia." @default.
- W4387364325 created "2023-10-06" @default.
- W4387364325 creator A5008684956 @default.
- W4387364325 creator A5010437672 @default.
- W4387364325 creator A5027551287 @default.
- W4387364325 creator A5032718790 @default.
- W4387364325 creator A5033500828 @default.
- W4387364325 creator A5045198574 @default.
- W4387364325 creator A5048122806 @default.
- W4387364325 creator A5087446063 @default.
- W4387364325 date "2023-10-05" @default.
- W4387364325 modified "2023-10-17" @default.
- W4387364325 title "Calsarcin-2 May Play a Compensatory Role in the Development of Obese Sarcopenia" @default.
- W4387364325 doi "https://doi.org/10.3390/biomedicines11102708" @default.
- W4387364325 hasPublicationYear "2023" @default.
- W4387364325 type Work @default.
- W4387364325 citedByCount "0" @default.
- W4387364325 crossrefType "journal-article" @default.
- W4387364325 hasAuthorship W4387364325A5008684956 @default.
- W4387364325 hasAuthorship W4387364325A5010437672 @default.
- W4387364325 hasAuthorship W4387364325A5027551287 @default.
- W4387364325 hasAuthorship W4387364325A5032718790 @default.
- W4387364325 hasAuthorship W4387364325A5033500828 @default.
- W4387364325 hasAuthorship W4387364325A5045198574 @default.
- W4387364325 hasAuthorship W4387364325A5048122806 @default.
- W4387364325 hasAuthorship W4387364325A5087446063 @default.
- W4387364325 hasBestOaLocation W43873643251 @default.
- W4387364325 hasConcept C104317684 @default.
- W4387364325 hasConcept C126322002 @default.
- W4387364325 hasConcept C134018914 @default.
- W4387364325 hasConcept C173396325 @default.
- W4387364325 hasConcept C207200792 @default.
- W4387364325 hasConcept C2776214593 @default.
- W4387364325 hasConcept C2779959927 @default.
- W4387364325 hasConcept C2992343062 @default.
- W4387364325 hasConcept C3763915 @default.
- W4387364325 hasConcept C55493867 @default.
- W4387364325 hasConcept C60278653 @default.
- W4387364325 hasConcept C71924100 @default.
- W4387364325 hasConcept C86803240 @default.
- W4387364325 hasConcept C97816823 @default.
- W4387364325 hasConceptScore W4387364325C104317684 @default.
- W4387364325 hasConceptScore W4387364325C126322002 @default.
- W4387364325 hasConceptScore W4387364325C134018914 @default.
- W4387364325 hasConceptScore W4387364325C173396325 @default.
- W4387364325 hasConceptScore W4387364325C207200792 @default.
- W4387364325 hasConceptScore W4387364325C2776214593 @default.
- W4387364325 hasConceptScore W4387364325C2779959927 @default.
- W4387364325 hasConceptScore W4387364325C2992343062 @default.
- W4387364325 hasConceptScore W4387364325C3763915 @default.
- W4387364325 hasConceptScore W4387364325C55493867 @default.
- W4387364325 hasConceptScore W4387364325C60278653 @default.
- W4387364325 hasConceptScore W4387364325C71924100 @default.
- W4387364325 hasConceptScore W4387364325C86803240 @default.
- W4387364325 hasConceptScore W4387364325C97816823 @default.
- W4387364325 hasFunder F4320331164 @default.
- W4387364325 hasIssue "10" @default.
- W4387364325 hasLocation W43873643251 @default.
- W4387364325 hasOpenAccess W4387364325 @default.
- W4387364325 hasPrimaryLocation W43873643251 @default.
- W4387364325 hasRelatedWork W1513212670 @default.
- W4387364325 hasRelatedWork W1982889849 @default.
- W4387364325 hasRelatedWork W2012211023 @default.
- W4387364325 hasRelatedWork W2019571841 @default.
- W4387364325 hasRelatedWork W2128344441 @default.
- W4387364325 hasRelatedWork W2349890314 @default.
- W4387364325 hasRelatedWork W2528224757 @default.
- W4387364325 hasRelatedWork W3116270792 @default.
- W4387364325 hasRelatedWork W3171772225 @default.
- W4387364325 hasRelatedWork W4293353538 @default.
- W4387364325 hasVolume "11" @default.
- W4387364325 isParatext "false" @default.
- W4387364325 isRetracted "false" @default.
- W4387364325 workType "article" @default.