FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387364853> ?p ?o ?g. }

• W4387364853 abstract "Abstract Emerging evidences suggest that immune receptors participate in diverse microglial and macrophage functions by regulating their immunometabolism, inflammatory phenotype and phagocytosis. CD300f, a TREM2-like lipid sensing immune receptor, that integrates activating and inhibitory cell-signalling pathways, modulates inflammation, efferocytosis and microglial metabolic fitness. In particular, CD300f overexpression was described to be neuroprotective after an acute brain injury, suggesting a role for this immune receptor in neurotrophic interactions. Thus, we hypothesised that CD300f modulates neuronal survival through neuron-microglial interactions. In order to study its biological function, we used in vitro and in vivo approaches, CD300f −/− animals and rCD300f-Fc, a fusion protein that interrupts the endogen interaction between CD300f receptor-ligands. In hippocampal cocultures containing neurons and mixed glia, we observed that rCD300f-Fc, but not control IgGs induced neuronal death. In accordance, in vivo studies performed by injecting rCD300f-Fc or control IgGs into rat or WT or CD300 KO mice neocortex, showed an increased lesioned area after a penetrating brain injury. Interestingly, this neuronal death was dependent on glia, and the neurotoxic mechanism did not involve the increase of proinflammatory cytokines, the participation of NMDA receptors or ATP release. However, exogenous addition of glial cell line-derived neurotrophic factor (GDNF) prevented this process. Taken together, our results suggest that CD300f modulates neuronal survival in vitro and after a penetrating brain injury in vivo and that CD300f inhibition alters microglial phenotype generating a neurotoxic microenvironment." @default.
• W4387364853 created "2023-10-06" @default.
• W4387364853 creator A5002455831 @default.
• W4387364853 creator A5020836602 @default.
• W4387364853 creator A5064603594 @default.
• W4387364853 date "2023-10-05" @default.
• W4387364853 modified "2023-10-11" @default.
• W4387364853 title "Microglial CD300f immune receptor contributes to the maintenance of neuron viability in vitro and after a penetrating brain injury" @default.
• W4387364853 cites W1556676228 @default.
• W4387364853 cites W1571909667 @default.
• W4387364853 cites W1675757545 @default.
• W4387364853 cites W1770378670 @default.
• W4387364853 cites W1972416550 @default.
• W4387364853 cites W1987378985 @default.
• W4387364853 cites W1989425374 @default.
• W4387364853 cites W2008560021 @default.
• W4387364853 cites W2011041653 @default.
• W4387364853 cites W2018805974 @default.
• W4387364853 cites W2023245989 @default.
• W4387364853 cites W2043844250 @default.
• W4387364853 cites W2054275187 @default.
• W4387364853 cites W2060530138 @default.
• W4387364853 cites W2064543932 @default.
• W4387364853 cites W2067104060 @default.
• W4387364853 cites W2076174419 @default.
• W4387364853 cites W2076269514 @default.
• W4387364853 cites W2101372125 @default.
• W4387364853 cites W2114797310 @default.
• W4387364853 cites W2130613483 @default.
• W4387364853 cites W2141098807 @default.
• W4387364853 cites W2143628004 @default.
• W4387364853 cites W2151928790 @default.
• W4387364853 cites W2159744102 @default.
• W4387364853 cites W2170060658 @default.
• W4387364853 cites W2280077905 @default.
• W4387364853 cites W2569247756 @default.
• W4387364853 cites W2572710398 @default.
• W4387364853 cites W2606080622 @default.
• W4387364853 cites W2743727231 @default.
• W4387364853 cites W2793210811 @default.
• W4387364853 cites W2806906155 @default.
• W4387364853 cites W2924084484 @default.
• W4387364853 cites W2948490412 @default.
• W4387364853 cites W2971202256 @default.
• W4387364853 cites W2990312754 @default.
• W4387364853 cites W3011259440 @default.
• W4387364853 cites W3105982350 @default.
• W4387364853 cites W3110756294 @default.
• W4387364853 cites W3131765363 @default.
• W4387364853 cites W3201931145 @default.
• W4387364853 cites W4224112147 @default.
• W4387364853 cites W4319344968 @default.
• W4387364853 doi "https://doi.org/10.1038/s41598-023-43840-1" @default.
• W4387364853 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37798310" @default.
• W4387364853 hasPublicationYear "2023" @default.
• W4387364853 type Work @default.
• W4387364853 citedByCount "0" @default.
• W4387364853 crossrefType "journal-article" @default.
• W4387364853 hasAuthorship W4387364853A5002455831 @default.
• W4387364853 hasAuthorship W4387364853A5020836602 @default.
• W4387364853 hasAuthorship W4387364853A5064603594 @default.
• W4387364853 hasBestOaLocation W43873648531 @default.
• W4387364853 hasConcept C126322002 @default.
• W4387364853 hasConcept C160539049 @default.
• W4387364853 hasConcept C164027704 @default.
• W4387364853 hasConcept C169760540 @default.
• W4387364853 hasConcept C170493617 @default.
• W4387364853 hasConcept C185856081 @default.
• W4387364853 hasConcept C190283241 @default.
• W4387364853 hasConcept C203014093 @default.
• W4387364853 hasConcept C25498285 @default.
• W4387364853 hasConcept C2776914184 @default.
• W4387364853 hasConcept C2776925932 @default.
• W4387364853 hasConcept C2779134260 @default.
• W4387364853 hasConcept C2779830541 @default.
• W4387364853 hasConcept C31573885 @default.
• W4387364853 hasConcept C55493867 @default.
• W4387364853 hasConcept C71924100 @default.
• W4387364853 hasConcept C86803240 @default.
• W4387364853 hasConcept C87753298 @default.
• W4387364853 hasConcept C92020748 @default.
• W4387364853 hasConcept C95444343 @default.
• W4387364853 hasConceptScore W4387364853C126322002 @default.
• W4387364853 hasConceptScore W4387364853C160539049 @default.
• W4387364853 hasConceptScore W4387364853C164027704 @default.
• W4387364853 hasConceptScore W4387364853C169760540 @default.
• W4387364853 hasConceptScore W4387364853C170493617 @default.
• W4387364853 hasConceptScore W4387364853C185856081 @default.
• W4387364853 hasConceptScore W4387364853C190283241 @default.
• W4387364853 hasConceptScore W4387364853C203014093 @default.
• W4387364853 hasConceptScore W4387364853C25498285 @default.
• W4387364853 hasConceptScore W4387364853C2776914184 @default.
• W4387364853 hasConceptScore W4387364853C2776925932 @default.
• W4387364853 hasConceptScore W4387364853C2779134260 @default.
• W4387364853 hasConceptScore W4387364853C2779830541 @default.
• W4387364853 hasConceptScore W4387364853C31573885 @default.
• W4387364853 hasConceptScore W4387364853C55493867 @default.
• W4387364853 hasConceptScore W4387364853C71924100 @default.
• W4387364853 hasConceptScore W4387364853C86803240 @default.
• W4387364853 hasConceptScore W4387364853C87753298 @default.

• next