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- W4387372868 abstract ": Urolithiasis disease is a severe pathology causing painful bleeding in patients and can lead to kidney failure. Current treatments are limited, expensive, invasive with side effects and requires new alternatives, especially those based on natural products. This work aimed to determine the in vivo antilithiasis effect of hydroalcoholic extract (E.PG) and infusion (I.PG) of the Punica granatum L. plant, as well as their antibacterial capacity against the strains responsible of urinary tract infection such as: E. coli, P. Mirabilis, K. pneumoniae and S. Aureus. : A curative protocol was followed, which consisted of inducing calcium oxalate lithiasis in rats by ethylene glycol (75%) and ammonium chloride (1%) solutions. After 15 days of oxalocalcic lithiasis induction, plant extracts were administered to rats at two different doses (200 and 400 mg/kg/day), with potassium citrate (Cit.K) used as a positive control. Water intake, urine volume, pH and body weight were measured with crystalluria and histopathological examinations of the kidneys performed. The antibacterial activity was studied by the disk diffusion method and the minimum inhibitory concentration (MIC) method. The checkerboard technique was used to determine the interactions between the two extracts. : The results found show a significant effectiveness of the Punica granatum L. extracts, especially the infusion in preventing the formation, development and calcium oxalate crystals deposition. In fact, crystalluria revealed an important diuresis with the presence of a very low crystals number (<50 / mm3) of very small size in the rat's urine treated with EPG and IPG at the concentration of 400 mg/kg/day. Kidney histopathology analysis showed the absence of crystal deposition, as well as an almost normal structure. Moreover, the antimicrobial activity showed the efficiency of the plant extracts in inhibiting the growth of P. mirabilis and S. aureus where the inhibition zones (IZ) revealed by the disk diffusion method are between 14 and 16 mm. I.PG extract displayed a very low MIC of 1.875 against E. coli. Furthermore, the interaction between these two extracts showed partial synergy and an additive effect against S. Aureus and K. pneumoniae. : Punica granatum L. plant has promising antilithiasis and antibacterial effects. Therefore, future extensive studies are needed to establish its effectiveness for clinical use." @default.
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- W4387372868 date "2023-11-01" @default.
- W4387372868 modified "2023-10-09" @default.
- W4387372868 title "In vivo Anti-lithiasis activity and antibacterial effect of hydroalcoholic extract and infusion of Punica granatum L. peel." @default.
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- W4387372868 cites W2037647875 @default.
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- W4387372868 cites W2105884781 @default.
- W4387372868 cites W2116479226 @default.
- W4387372868 cites W2119529491 @default.
- W4387372868 cites W2123712436 @default.
- W4387372868 cites W2156179484 @default.
- W4387372868 cites W2162127145 @default.
- W4387372868 cites W2195693410 @default.
- W4387372868 cites W2247415440 @default.
- W4387372868 cites W2311688542 @default.
- W4387372868 cites W2322340619 @default.
- W4387372868 cites W2326266744 @default.
- W4387372868 cites W2474271713 @default.
- W4387372868 cites W2502183412 @default.
- W4387372868 cites W2513189997 @default.
- W4387372868 cites W2541656995 @default.
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- W4387372868 cites W2559950310 @default.
- W4387372868 cites W2576059980 @default.
- W4387372868 cites W2616157113 @default.
- W4387372868 cites W2620823116 @default.
- W4387372868 cites W2624045896 @default.
- W4387372868 cites W2625623236 @default.
- W4387372868 cites W2660101217 @default.
- W4387372868 cites W2752905452 @default.
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- W4387372868 cites W2782828749 @default.
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- W4387372868 cites W3007231398 @default.
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- W4387372868 doi "https://doi.org/10.1016/j.sciaf.2023.e01918" @default.
- W4387372868 hasPublicationYear "2023" @default.
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