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- W4387373415 endingPage "989" @default.
- W4387373415 startingPage "989" @default.
- W4387373415 abstract "Upon the dysfunction or functional shortage of the endoplasmic reticulum (ER), namely, ER stress, eukaryotic cells commonly provoke a protective gene expression program called the unfolded protein response (UPR). The molecular mechanism of UPR has been uncovered through frontier genetic studies using Saccharomyces cerevisiae as a model organism. Ire1 is an ER-located transmembrane protein that directly senses ER stress and is activated as an RNase. During ER stress, Ire1 promotes the splicing of HAC1 mRNA, which is then translated into a transcription factor that induces the expression of various genes, including those encoding ER-located molecular chaperones and protein modification enzymes. While this mainstream intracellular UPR signaling pathway was elucidated in the 1990s, new intriguing insights have been gained up to now. For instance, various additional factors allow UPR evocation strictly in response to ER stress. The UPR machineries in other yeasts and fungi, including pathogenic species, are another important research topic. Moreover, industrially beneficial yeast strains carrying an enforced and enlarged ER have been produced through the artificial and constitutive induction of the UPR. In this article, we review canonical and up-to-date insights concerning the yeast UPR, mainly from the viewpoint of the functions and regulation of Ire1 and HAC1." @default.
- W4387373415 created "2023-10-06" @default.
- W4387373415 creator A5044567218 @default.
- W4387373415 creator A5058201816 @default.
- W4387373415 date "2023-10-05" @default.
- W4387373415 modified "2023-10-16" @default.
- W4387373415 title "Fundamental and Applicative Aspects of the Unfolded Protein Response in Yeasts" @default.
- W4387373415 cites W1546139069 @default.
- W4387373415 cites W1575978940 @default.
- W4387373415 cites W1576656496 @default.
- W4387373415 cites W1707619101 @default.
- W4387373415 cites W1770756340 @default.
- W4387373415 cites W1822717876 @default.
- W4387373415 cites W1964324370 @default.
- W4387373415 cites W1976812939 @default.
- W4387373415 cites W1977352903 @default.
- W4387373415 cites W1980120189 @default.
- W4387373415 cites W1985009919 @default.
- W4387373415 cites W1986290768 @default.
- W4387373415 cites W1990136127 @default.
- W4387373415 cites W1990400035 @default.
- W4387373415 cites W1992299163 @default.
- W4387373415 cites W1993697882 @default.
- W4387373415 cites W2003755766 @default.
- W4387373415 cites W2011092448 @default.
- W4387373415 cites W2014783900 @default.
- W4387373415 cites W2020437934 @default.
- W4387373415 cites W2025300600 @default.
- W4387373415 cites W2027291842 @default.
- W4387373415 cites W2028215693 @default.
- W4387373415 cites W2033015454 @default.
- W4387373415 cites W2042688172 @default.
- W4387373415 cites W2045368652 @default.
- W4387373415 cites W2046640957 @default.
- W4387373415 cites W2047498253 @default.
- W4387373415 cites W2049070379 @default.
- W4387373415 cites W2053751454 @default.
- W4387373415 cites W2056037336 @default.
- W4387373415 cites W2060084781 @default.
- W4387373415 cites W2078700501 @default.
- W4387373415 cites W2081294646 @default.
- W4387373415 cites W2083445344 @default.
- W4387373415 cites W2094070149 @default.
- W4387373415 cites W2096947765 @default.
- W4387373415 cites W2100991511 @default.
- W4387373415 cites W2105556300 @default.
- W4387373415 cites W2106983618 @default.
- W4387373415 cites W2108744823 @default.
- W4387373415 cites W2111587627 @default.
- W4387373415 cites W2112736223 @default.
- W4387373415 cites W2117293299 @default.
- W4387373415 cites W2122028944 @default.
- W4387373415 cites W2125253481 @default.
- W4387373415 cites W2126889815 @default.
- W4387373415 cites W2131450597 @default.
- W4387373415 cites W2133112227 @default.
- W4387373415 cites W2136338518 @default.
- W4387373415 cites W2136963008 @default.
- W4387373415 cites W2137755719 @default.
- W4387373415 cites W2140437400 @default.
- W4387373415 cites W2142022696 @default.
- W4387373415 cites W2143386697 @default.
- W4387373415 cites W2147830108 @default.
- W4387373415 cites W2148125211 @default.
- W4387373415 cites W2155163967 @default.
- W4387373415 cites W2155280757 @default.
- W4387373415 cites W2158837517 @default.
- W4387373415 cites W2165362327 @default.
- W4387373415 cites W2167095297 @default.
- W4387373415 cites W2168092724 @default.
- W4387373415 cites W2170942986 @default.
- W4387373415 cites W2171432169 @default.
- W4387373415 cites W2192080449 @default.
- W4387373415 cites W2329441247 @default.
- W4387373415 cites W2416419927 @default.
- W4387373415 cites W2462203997 @default.
- W4387373415 cites W2507571573 @default.
- W4387373415 cites W2570803729 @default.
- W4387373415 cites W2727065253 @default.
- W4387373415 cites W2758359428 @default.
- W4387373415 cites W2770932609 @default.
- W4387373415 cites W2789622875 @default.
- W4387373415 cites W2792238812 @default.
- W4387373415 cites W2804764249 @default.
- W4387373415 cites W2807378807 @default.
- W4387373415 cites W2878758614 @default.
- W4387373415 cites W2883606517 @default.
- W4387373415 cites W2886315980 @default.
- W4387373415 cites W2895980426 @default.
- W4387373415 cites W2899572183 @default.
- W4387373415 cites W2904223696 @default.
- W4387373415 cites W2913545721 @default.
- W4387373415 cites W2953742709 @default.
- W4387373415 cites W2962903111 @default.
- W4387373415 cites W2971545262 @default.
- W4387373415 cites W2989581073 @default.
- W4387373415 cites W2992872079 @default.
- W4387373415 cites W3008323964 @default.