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• W4387374150 abstract "BackgroundThe impact of the timing of surgery on neurological recovery in thoracolumbar spinal cord injuries (tSCI) is still a subject of discussion. Accumulating evidence is supporting early decompression (<24 hours) following tSCI. However, the potential advantages of earlier decompression remain uncertain. This systematic review and meta-analysis summarizes and analyzes the current evidence on the effectiveness of ultra-early decompression surgery on clinical outcomes following tSCI.MethodsA search was conducted in the electronic databases Medline, Embase, Scopus, and Web of Science from their inception until May 2022 for human studies. Groups were stratified into ultra-early (surgery within 8 hours of injury) vs control group operated >8 hours of injury. The authors included the study data from their institutional case series of thoracolumbar spinal cord injury from 2015-2018. An arm-based meta-analysis was performed on all studies using the R Studio. For studies that qualified, a contrast-based meta-analysis was also performed with standardized mean difference (SMD). Outcomes were reported as effect size, treatment effect, and effect difference, all with 95% confidence intervals (CI).ResultsOf the 133 patients, 74.4% patients were male. 76 (57.1%) underwent decompression ≤8hrs, while 57 (42.9%) underwent decompression >8 hours from injury. Quantitative analysis using the SMD model showed a significant difference in mean AIS improvement in the ultra-early group [Effect size 1.15 (0.62-1.67), p<0.0001]. On arm-based meta-analysis, a statistically significant treatment effect was found for ultra-early arm [1.25 (0.91-1.67)], while >8hour arm did not show significance [0.30 (-0.08-0.71)]. There was statistically significant effect difference between two arms [0.96 (0.49-1.48)].ConclusionThis study observed a significant improvement in mean AIS score in patients undergoing decompression within 8 hours of tSCI. Given the scant literature regarding ultra-early decompression of tSCI, this study solidifies the need to further explore the role of early interventions for tSCIs to improve patient outcomes." @default.
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• W4387374150 date "2023-10-01" @default.
• W4387374150 modified "2023-10-16" @default.
• W4387374150 title "Ultra-early (≤8 hours) Surgery for Thoracolumbar Spinal Cord Injuries: A Systematic Review and Meta-analysis" @default.
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• W4387374150 doi "https://doi.org/10.1016/j.xnsj.2023.100285" @default.
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