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- W4387375541 abstract "SARS-CoV-2 antibody quantity and quality are key markers of humoral immunity. However, there is substantial uncertainty about their durability. We investigated levels and temporal change of SARS-CoV-2 antibody quantity and quality. We analyzed sera (8 binding, 4 avidity assays for spike-(S-)protein and nucleocapsid-(N-)protein; neutralization) from 211 seropositive unvaccinated participants, from the population-based longitudinal TiKoCo study, at three time points within one year after infection with the ancestral SARS-CoV-2 virus. We found a significant decline of neutralization titers and binding antibody levels in most assays (linear mixed regression model, p<0.01). S-specific serum avidity increased markedly over time, in contrast to N-specific. Binding antibody levels were higher in older versus younger participants – a difference that disappeared for the asymptomatic-infected. We found stronger antibody decline in men versus women and lower binding and avidity levels in current versus never-smokers. Our comprehensive longitudinal analyses across 13 antibody assays suggest decreased neutralization-based protection and prolonged affinity maturation within one year after infection." @default.
- W4387375541 created "2023-10-06" @default.
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- W4387375541 date "2023-10-05" @default.
- W4387375541 modified "2023-10-16" @default.
- W4387375541 title "Population-based study of the durability of humoral immunity after SARS-CoV-2 infection" @default.
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- W4387375541 doi "https://doi.org/10.3389/fimmu.2023.1242536" @default.
- W4387375541 hasPublicationYear "2023" @default.
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