Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387375713> ?p ?o ?g. }
- W4387375713 abstract "Extracellular vesicles derived from mesenchymal stem/stromal cells (MSCs) have shown therapeutic effects on liver fibrosis. This study aimed to evaluate the effects of extracellular vesicles from placenta-derived MSCs (Pd-MSCs-EVs) on liver fibrosis at 3D/2D levels and explore the potential mechanisms.The multicellular liver organoids, consisting of hepatocytes, hepatic stellate cells (HSCs), Kupffer cells, and liver sinusoidal endothelial cells, were observed for growth status, morphological changes, and metabolism. Human transformation growth factor- beta 1 (TGF-β1) was used to induce fibrosis at optimal concentration. The anti-fibrosis effects of Pd-MSCs-EVs were evaluated in liver organoids and HSCs models. Anti-fibrotic content of Pd-MSCs-EVs was identified by multiple experimental validations.TGF-β1 induced fibrosis in liver organoids, while Pd-MSCs-EVs significantly alleviated fibrotic phenotypes. Following serial verifications, miR-378c was identified as a potential key anti-fibrosis content. In contrast, miR-378c depletion decreased the anti-fibrotic effects of Pd-MSCs-EVs. Additionally, Pd-MSCs-EVs administration repressed TGF-β1-mediated HSCs activation at 2D or 3D levels. Mechanistically, exosomal miR-378c inactivated HSCs by inhibiting epithelial-mesenchymal transition (EMT) through stabilizing E-cadherin via targeting its E3 ubiquitin ligase S-Phase Kinase Associated Protein 2 (SKP2).Pd-MSCs-EVs ameliorated TGF-β1-induced fibrosis by deactivating HSCs in a miR-378c/SKP2-dependent manner, which may be an efficient therapeutic candidate for liver fibrosis." @default.
- W4387375713 created "2023-10-06" @default.
- W4387375713 creator A5004713760 @default.
- W4387375713 creator A5019995632 @default.
- W4387375713 creator A5030802910 @default.
- W4387375713 creator A5037645646 @default.
- W4387375713 creator A5042449700 @default.
- W4387375713 creator A5069617381 @default.
- W4387375713 creator A5076933086 @default.
- W4387375713 creator A5077126925 @default.
- W4387375713 creator A5088147402 @default.
- W4387375713 creator A5088989949 @default.
- W4387375713 creator A5090399752 @default.
- W4387375713 date "2023-10-05" @default.
- W4387375713 modified "2023-10-17" @default.
- W4387375713 title "Placenta mesenchymal stem cell-derived extracellular vesicles alleviate liver fibrosis by inactivating hepatic stellate cells through a miR-378c/SKP2 axis" @default.
- W4387375713 cites W1964082391 @default.
- W4387375713 cites W2035617243 @default.
- W4387375713 cites W2060387475 @default.
- W4387375713 cites W2119742103 @default.
- W4387375713 cites W2131097780 @default.
- W4387375713 cites W2181115262 @default.
- W4387375713 cites W2254654454 @default.
- W4387375713 cites W2405091380 @default.
- W4387375713 cites W2487947432 @default.
- W4387375713 cites W2502245767 @default.
- W4387375713 cites W2562949639 @default.
- W4387375713 cites W2564777109 @default.
- W4387375713 cites W2608293540 @default.
- W4387375713 cites W2612740690 @default.
- W4387375713 cites W2662093608 @default.
- W4387375713 cites W2733683784 @default.
- W4387375713 cites W2770927985 @default.
- W4387375713 cites W2783337717 @default.
- W4387375713 cites W2791947034 @default.
- W4387375713 cites W2796699845 @default.
- W4387375713 cites W2883298821 @default.
- W4387375713 cites W2890324251 @default.
- W4387375713 cites W2890778790 @default.
- W4387375713 cites W2903679390 @default.
- W4387375713 cites W2906567884 @default.
- W4387375713 cites W2911033210 @default.
- W4387375713 cites W2913199259 @default.
- W4387375713 cites W2970953638 @default.
- W4387375713 cites W3000568230 @default.
- W4387375713 cites W3006118590 @default.
- W4387375713 cites W3008895845 @default.
- W4387375713 cites W3009361827 @default.
- W4387375713 cites W3045339283 @default.
- W4387375713 cites W3127821066 @default.
- W4387375713 cites W3174150721 @default.
- W4387375713 cites W3176944510 @default.
- W4387375713 cites W3195818350 @default.
- W4387375713 cites W3203866006 @default.
- W4387375713 cites W4200351549 @default.
- W4387375713 cites W4212845711 @default.
- W4387375713 cites W4223486219 @default.
- W4387375713 cites W4226167918 @default.
- W4387375713 cites W4226231316 @default.
- W4387375713 cites W4280573773 @default.
- W4387375713 cites W4281763241 @default.
- W4387375713 cites W4284989290 @default.
- W4387375713 cites W4285891338 @default.
- W4387375713 cites W4286512445 @default.
- W4387375713 cites W4287510231 @default.
- W4387375713 cites W4288724495 @default.
- W4387375713 cites W4289782317 @default.
- W4387375713 doi "https://doi.org/10.1186/s41232-023-00297-z" @default.
- W4387375713 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37798761" @default.
- W4387375713 hasPublicationYear "2023" @default.
- W4387375713 type Work @default.
- W4387375713 citedByCount "0" @default.
- W4387375713 crossrefType "journal-article" @default.
- W4387375713 hasAuthorship W4387375713A5004713760 @default.
- W4387375713 hasAuthorship W4387375713A5019995632 @default.
- W4387375713 hasAuthorship W4387375713A5030802910 @default.
- W4387375713 hasAuthorship W4387375713A5037645646 @default.
- W4387375713 hasAuthorship W4387375713A5042449700 @default.
- W4387375713 hasAuthorship W4387375713A5069617381 @default.
- W4387375713 hasAuthorship W4387375713A5076933086 @default.
- W4387375713 hasAuthorship W4387375713A5077126925 @default.
- W4387375713 hasAuthorship W4387375713A5088147402 @default.
- W4387375713 hasAuthorship W4387375713A5088989949 @default.
- W4387375713 hasAuthorship W4387375713A5090399752 @default.
- W4387375713 hasBestOaLocation W43873757131 @default.
- W4387375713 hasConcept C104317684 @default.
- W4387375713 hasConcept C127561419 @default.
- W4387375713 hasConcept C134018914 @default.
- W4387375713 hasConcept C142724271 @default.
- W4387375713 hasConcept C176891718 @default.
- W4387375713 hasConcept C185592680 @default.
- W4387375713 hasConcept C198826908 @default.
- W4387375713 hasConcept C2780559512 @default.
- W4387375713 hasConcept C28328180 @default.
- W4387375713 hasConcept C2993667909 @default.
- W4387375713 hasConcept C502942594 @default.
- W4387375713 hasConcept C55493867 @default.
- W4387375713 hasConcept C71924100 @default.
- W4387375713 hasConcept C76419328 @default.
- W4387375713 hasConcept C86803240 @default.