Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387376089> ?p ?o ?g. }
- W4387376089 abstract "Thyroid hormone (TH) signaling plays a major role in mammalian brain development. Data obtained in the past years in animal models have pinpointed GABAergic neurons as a major target of TH signaling during development, which opens up new perspectives to further investigate the mechanisms by which TH affects brain development. The aim of the present review is to gather the available information about the involvement of TH in the maturation of GABAergic neurons. After giving an overview of the kinds of neurological disorders that may arise from disruption of TH signaling during brain development in humans, we will take a historical perspective to show how rodent models of hypothyroidism have gradually pointed to GABAergic neurons as a main target of TH signaling during brain development. The third part of this review underscores the challenges that are encountered when conducting gene expression studies to investigate the molecular mechanisms that are at play downstream of TH receptors during brain development. Unravelling the mechanisms of action of TH in the developing brain should help make progress in the prevention and treatment of several neurological disorders, including autism and epilepsy." @default.
- W4387376089 created "2023-10-06" @default.
- W4387376089 creator A5047005201 @default.
- W4387376089 creator A5055826574 @default.
- W4387376089 creator A5079564527 @default.
- W4387376089 date "2023-10-03" @default.
- W4387376089 modified "2023-10-14" @default.
- W4387376089 title "Thyroid hormone action during GABAergic neuron maturation: The quest for mechanisms" @default.
- W4387376089 cites W1485428340 @default.
- W4387376089 cites W1539467957 @default.
- W4387376089 cites W1592115964 @default.
- W4387376089 cites W1965162553 @default.
- W4387376089 cites W1965357288 @default.
- W4387376089 cites W1966126295 @default.
- W4387376089 cites W1986428182 @default.
- W4387376089 cites W1987808721 @default.
- W4387376089 cites W1990329100 @default.
- W4387376089 cites W1990584061 @default.
- W4387376089 cites W1993317384 @default.
- W4387376089 cites W1995526292 @default.
- W4387376089 cites W1997612859 @default.
- W4387376089 cites W1999204296 @default.
- W4387376089 cites W2000741536 @default.
- W4387376089 cites W2004577135 @default.
- W4387376089 cites W2004800752 @default.
- W4387376089 cites W2015417034 @default.
- W4387376089 cites W2023999213 @default.
- W4387376089 cites W2024292910 @default.
- W4387376089 cites W2028347970 @default.
- W4387376089 cites W2030671831 @default.
- W4387376089 cites W2032591462 @default.
- W4387376089 cites W2032626296 @default.
- W4387376089 cites W2035087361 @default.
- W4387376089 cites W2036698185 @default.
- W4387376089 cites W2037312424 @default.
- W4387376089 cites W2043548753 @default.
- W4387376089 cites W2046037386 @default.
- W4387376089 cites W2050373894 @default.
- W4387376089 cites W2054106419 @default.
- W4387376089 cites W2054234898 @default.
- W4387376089 cites W2059254009 @default.
- W4387376089 cites W2059700149 @default.
- W4387376089 cites W2059894721 @default.
- W4387376089 cites W2065748069 @default.
- W4387376089 cites W2082068065 @default.
- W4387376089 cites W2084072056 @default.
- W4387376089 cites W2084135119 @default.
- W4387376089 cites W2085848059 @default.
- W4387376089 cites W2088566177 @default.
- W4387376089 cites W2090877505 @default.
- W4387376089 cites W2091829541 @default.
- W4387376089 cites W2093098405 @default.
- W4387376089 cites W2093324146 @default.
- W4387376089 cites W2094345187 @default.
- W4387376089 cites W2094705166 @default.
- W4387376089 cites W2095535117 @default.
- W4387376089 cites W2097440306 @default.
- W4387376089 cites W2109271456 @default.
- W4387376089 cites W2110945660 @default.
- W4387376089 cites W2114611737 @default.
- W4387376089 cites W2114633295 @default.
- W4387376089 cites W2123589424 @default.
- W4387376089 cites W2127859037 @default.
- W4387376089 cites W2128430557 @default.
- W4387376089 cites W2132779244 @default.
- W4387376089 cites W2133962334 @default.
- W4387376089 cites W2137164311 @default.
- W4387376089 cites W2140408970 @default.
- W4387376089 cites W2143237288 @default.
- W4387376089 cites W2149885497 @default.
- W4387376089 cites W2152345776 @default.
- W4387376089 cites W2158463114 @default.
- W4387376089 cites W2164383111 @default.
- W4387376089 cites W2165022229 @default.
- W4387376089 cites W2166454277 @default.
- W4387376089 cites W2166896177 @default.
- W4387376089 cites W2171716250 @default.
- W4387376089 cites W2223535087 @default.
- W4387376089 cites W2262634912 @default.
- W4387376089 cites W2287640117 @default.
- W4387376089 cites W2294392975 @default.
- W4387376089 cites W2307407239 @default.
- W4387376089 cites W2495886275 @default.
- W4387376089 cites W2587885056 @default.
- W4387376089 cites W2605746803 @default.
- W4387376089 cites W2751223399 @default.
- W4387376089 cites W2772598674 @default.
- W4387376089 cites W2791947108 @default.
- W4387376089 cites W2799819050 @default.
- W4387376089 cites W2807106799 @default.
- W4387376089 cites W2889283221 @default.
- W4387376089 cites W2921840173 @default.
- W4387376089 cites W2934358708 @default.
- W4387376089 cites W2936237754 @default.
- W4387376089 cites W2964405640 @default.
- W4387376089 cites W2967193152 @default.
- W4387376089 cites W2980570592 @default.
- W4387376089 cites W3005403791 @default.
- W4387376089 cites W3009322230 @default.
- W4387376089 cites W3012924529 @default.