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- W4387376550 endingPage "2706" @default.
- W4387376550 startingPage "2706" @default.
- W4387376550 abstract "Lung cancer accounts for the highest number of deaths among men and women worldwide. Although extensive therapies, either alone or in conjunction with some specific drugs, continue to be the principal regimen for evolving lung cancer, significant improvements are still needed to understand the inherent biology behind progressive inflammation and its detection. Unfortunately, despite every advancement in its treatment, lung cancer patients display different growth mechanisms and continue to die at significant rates. Autophagy, which is a physiological defense mechanism, serves to meet the energy demands of nutrient-deprived cancer cells and sustain the tumor cells under stressed conditions. In contrast, autophagy is believed to play a dual role during different stages of tumorigenesis. During early stages, it acts as a tumor suppressor, degrading oncogenic proteins; however, during later stages, autophagy supports tumor cell survival by minimizing stress in the tumor microenvironment. The pivotal role of the IL6-IL17-IL23 signaling axis has been observed to trigger autophagic events in lung cancer patients. Since the obvious roles of autophagy are a result of different immune signaling cascades, systems biology can be an effective tool to understand these interconnections and enhance cancer treatment and immunotherapy. In this review, we focus on how systems biology can be exploited to target autophagic processes that resolve inflammatory responses and contribute to better treatment in carcinogenesis." @default.
- W4387376550 created "2023-10-06" @default.
- W4387376550 creator A5085151831 @default.
- W4387376550 creator A5092835060 @default.
- W4387376550 date "2023-10-05" @default.
- W4387376550 modified "2023-10-16" @default.
- W4387376550 title "Systems Biology and Cytokines Potential Role in Lung Cancer Immunotherapy Targeting Autophagic Axis" @default.
- W4387376550 cites W1482715126 @default.
- W4387376550 cites W1607828984 @default.
- W4387376550 cites W1624269400 @default.
- W4387376550 cites W1895277992 @default.
- W4387376550 cites W1901355048 @default.
- W4387376550 cites W1963904011 @default.
- W4387376550 cites W1964081206 @default.
- W4387376550 cites W1968444524 @default.
- W4387376550 cites W1969752146 @default.
- W4387376550 cites W1970637701 @default.
- W4387376550 cites W1971620413 @default.
- W4387376550 cites W1972719386 @default.
- W4387376550 cites W1974600881 @default.
- W4387376550 cites W1979402779 @default.
- W4387376550 cites W1980339030 @default.
- W4387376550 cites W1986810195 @default.
- W4387376550 cites W1996362044 @default.
- W4387376550 cites W2004994658 @default.
- W4387376550 cites W2005002911 @default.
- W4387376550 cites W2005117785 @default.
- W4387376550 cites W2005334224 @default.
- W4387376550 cites W2008994285 @default.
- W4387376550 cites W2009405916 @default.
- W4387376550 cites W2009750277 @default.
- W4387376550 cites W2019460213 @default.
- W4387376550 cites W2021700900 @default.
- W4387376550 cites W2027216014 @default.
- W4387376550 cites W2028541216 @default.
- W4387376550 cites W2030058743 @default.
- W4387376550 cites W2041604269 @default.
- W4387376550 cites W2042198997 @default.
- W4387376550 cites W2049491375 @default.
- W4387376550 cites W2052649926 @default.
- W4387376550 cites W2057271458 @default.
- W4387376550 cites W2060748039 @default.
- W4387376550 cites W2063941210 @default.
- W4387376550 cites W2064741210 @default.
- W4387376550 cites W2069633550 @default.
- W4387376550 cites W2069929656 @default.
- W4387376550 cites W2070616601 @default.
- W4387376550 cites W2073068414 @default.
- W4387376550 cites W2073606915 @default.
- W4387376550 cites W2073963703 @default.
- W4387376550 cites W2080505763 @default.
- W4387376550 cites W2083009508 @default.
- W4387376550 cites W2083604274 @default.
- W4387376550 cites W2086921112 @default.
- W4387376550 cites W2101241684 @default.
- W4387376550 cites W2104619485 @default.
- W4387376550 cites W2106353254 @default.
- W4387376550 cites W2108086395 @default.
- W4387376550 cites W2113432343 @default.
- W4387376550 cites W2114293452 @default.
- W4387376550 cites W2114806766 @default.
- W4387376550 cites W2116836791 @default.
- W4387376550 cites W2117529508 @default.
- W4387376550 cites W2117692326 @default.
- W4387376550 cites W2117897121 @default.
- W4387376550 cites W2118278569 @default.
- W4387376550 cites W2126882378 @default.
- W4387376550 cites W2129880161 @default.
- W4387376550 cites W2131487381 @default.
- W4387376550 cites W2132218677 @default.
- W4387376550 cites W2135870265 @default.
- W4387376550 cites W2138600064 @default.
- W4387376550 cites W2138780264 @default.
- W4387376550 cites W2138906045 @default.
- W4387376550 cites W2139848396 @default.
- W4387376550 cites W2140239055 @default.
- W4387376550 cites W2140912399 @default.
- W4387376550 cites W2141629057 @default.
- W4387376550 cites W2142072523 @default.
- W4387376550 cites W2143100947 @default.
- W4387376550 cites W2144323242 @default.
- W4387376550 cites W2147947403 @default.
- W4387376550 cites W2150767029 @default.
- W4387376550 cites W2152604814 @default.
- W4387376550 cites W2153077235 @default.
- W4387376550 cites W2153624566 @default.
- W4387376550 cites W2154516787 @default.
- W4387376550 cites W2157096314 @default.
- W4387376550 cites W2159754384 @default.
- W4387376550 cites W2161050915 @default.
- W4387376550 cites W2164142048 @default.
- W4387376550 cites W2164551855 @default.
- W4387376550 cites W2167656141 @default.
- W4387376550 cites W2176134716 @default.
- W4387376550 cites W2290893624 @default.
- W4387376550 cites W2315187051 @default.
- W4387376550 cites W2330998918 @default.
- W4387376550 cites W2411328842 @default.