Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387376675> ?p ?o ?g. }
- W4387376675 endingPage "546" @default.
- W4387376675 startingPage "532" @default.
- W4387376675 abstract "Pancreatic ductal adenocarcinoma (PDAC) is one of the leading causes of cancer-related death. Therefore, we intend to explore novel strategies against PDAC. The exosomes-based biomimetic nanoparticle is an appealing candidate served as a drug carrier in cancer treatment, due to its inherit abilities. In the present study, we designed dasatinib-loaded hybrid exosomes by fusing human pancreatic cancer cells derived exosomes with dasatinib-loaded liposomes, followed by characterization for particle size (119.9 ± 6.10 nm) and zeta potential (−11.45 ± 2.24 mV). Major protein analysis from western blot techniques reveal the presence of exosome marker proteins CD9 and CD81. PEGylated hybrid exosomes showed pH-sensitive drug release in acidic condition, benefiting drug delivery to acidic cancer environment. Dasatinib-loaded hybrid exosomes exhibited significantly higher uptake rates and cytotoxicity to parent PDAC cells by two-sample t-test or by one-way ANOVA analysis of variance, as compared to free drug or liposomal formulations. The results from our computational analysis demonstrated that the drug-likeness, ADMET, and protein-ligand binding affinity of dasatinib are verified successfully. Cancer derived hybrid exosomes may serve as a potential therapeutic candidate for pancreatic cancer treatment." @default.
- W4387376675 created "2023-10-06" @default.
- W4387376675 creator A5002551693 @default.
- W4387376675 creator A5007300128 @default.
- W4387376675 creator A5020045522 @default.
- W4387376675 creator A5031364662 @default.
- W4387376675 creator A5033295592 @default.
- W4387376675 creator A5037841594 @default.
- W4387376675 creator A5057117181 @default.
- W4387376675 creator A5064097264 @default.
- W4387376675 creator A5071928081 @default.
- W4387376675 creator A5078929454 @default.
- W4387376675 creator A5081675173 @default.
- W4387376675 creator A5086257868 @default.
- W4387376675 creator A5086497754 @default.
- W4387376675 date "2023-10-05" @default.
- W4387376675 modified "2023-10-16" @default.
- W4387376675 title "Study on tumour cell-derived hybrid exosomes as dasatinib nanocarriers for pancreatic cancer therapy" @default.
- W4387376675 cites W136971731 @default.
- W4387376675 cites W1507070939 @default.
- W4387376675 cites W1963747091 @default.
- W4387376675 cites W1976588710 @default.
- W4387376675 cites W1986069559 @default.
- W4387376675 cites W1987136886 @default.
- W4387376675 cites W1994948303 @default.
- W4387376675 cites W1998724112 @default.
- W4387376675 cites W2003343932 @default.
- W4387376675 cites W2038236600 @default.
- W4387376675 cites W2054077259 @default.
- W4387376675 cites W2074473216 @default.
- W4387376675 cites W2077951379 @default.
- W4387376675 cites W2085178300 @default.
- W4387376675 cites W2085959020 @default.
- W4387376675 cites W2086658271 @default.
- W4387376675 cites W2098253798 @default.
- W4387376675 cites W2123145623 @default.
- W4387376675 cites W2126400039 @default.
- W4387376675 cites W2133501340 @default.
- W4387376675 cites W2134967712 @default.
- W4387376675 cites W2135732933 @default.
- W4387376675 cites W213604786 @default.
- W4387376675 cites W2142921483 @default.
- W4387376675 cites W2155441983 @default.
- W4387376675 cites W2170449834 @default.
- W4387376675 cites W2406609064 @default.
- W4387376675 cites W2470589238 @default.
- W4387376675 cites W2620998958 @default.
- W4387376675 cites W2756322300 @default.
- W4387376675 cites W2760919908 @default.
- W4387376675 cites W2782416903 @default.
- W4387376675 cites W2786514708 @default.
- W4387376675 cites W2793760887 @default.
- W4387376675 cites W2795610460 @default.
- W4387376675 cites W2806414351 @default.
- W4387376675 cites W2809560445 @default.
- W4387376675 cites W2827777376 @default.
- W4387376675 cites W2921948547 @default.
- W4387376675 cites W2946585494 @default.
- W4387376675 cites W2948520738 @default.
- W4387376675 cites W2969354046 @default.
- W4387376675 cites W2993347499 @default.
- W4387376675 cites W3018717450 @default.
- W4387376675 cites W3045220329 @default.
- W4387376675 cites W3045740151 @default.
- W4387376675 cites W3084418967 @default.
- W4387376675 cites W3097074834 @default.
- W4387376675 cites W3111158352 @default.
- W4387376675 cites W3137357006 @default.
- W4387376675 cites W3143831139 @default.
- W4387376675 cites W3154091431 @default.
- W4387376675 cites W3154258817 @default.
- W4387376675 cites W3159937903 @default.
- W4387376675 cites W3164460400 @default.
- W4387376675 cites W3172324318 @default.
- W4387376675 cites W3173043499 @default.
- W4387376675 cites W3188243155 @default.
- W4387376675 cites W4206841660 @default.
- W4387376675 cites W4229080685 @default.
- W4387376675 cites W4282940093 @default.
- W4387376675 cites W4296149831 @default.
- W4387376675 cites W4308262761 @default.
- W4387376675 cites W4366449363 @default.
- W4387376675 doi "https://doi.org/10.1080/21691401.2023.2264358" @default.
- W4387376675 hasPublicationYear "2023" @default.
- W4387376675 type Work @default.
- W4387376675 citedByCount "0" @default.
- W4387376675 crossrefType "journal-article" @default.
- W4387376675 hasAuthorship W4387376675A5002551693 @default.
- W4387376675 hasAuthorship W4387376675A5007300128 @default.
- W4387376675 hasAuthorship W4387376675A5020045522 @default.
- W4387376675 hasAuthorship W4387376675A5031364662 @default.
- W4387376675 hasAuthorship W4387376675A5033295592 @default.
- W4387376675 hasAuthorship W4387376675A5037841594 @default.
- W4387376675 hasAuthorship W4387376675A5057117181 @default.
- W4387376675 hasAuthorship W4387376675A5064097264 @default.
- W4387376675 hasAuthorship W4387376675A5071928081 @default.
- W4387376675 hasAuthorship W4387376675A5078929454 @default.
- W4387376675 hasAuthorship W4387376675A5081675173 @default.