Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387377002> ?p ?o ?g. }
- W4387377002 endingPage "3557.e8" @default.
- W4387377002 startingPage "3546" @default.
- W4387377002 abstract "Nonstructural protein 1 (Nsp1) produced by coronaviruses inhibits host protein synthesis. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Nsp1 C-terminal domain was shown to bind the ribosomal mRNA channel to inhibit translation, but it is unclear whether this mechanism is broadly used by coronaviruses, whether the Nsp1 N-terminal domain binds the ribosome, or how Nsp1 allows viral RNAs to be translated. Here, we investigated Nsp1 from SARS-CoV-2, Middle East respiratory syndrome coronavirus (MERS-CoV), and Bat-Hp-CoV coronaviruses using structural, biophysical, and biochemical experiments, revealing a conserved role for the C-terminal domain. Additionally, the N-terminal domain of Bat-Hp-CoV Nsp1 binds to the decoding center of the 40S subunit, where it would prevent mRNA and eIF1A accommodation. Structure-based experiments demonstrated the importance of decoding center interactions in all three coronaviruses and showed that the same regions of Nsp1 are necessary for the selective translation of viral RNAs. Our results provide a mechanistic framework to understand how Nsp1 controls preferential translation of viral RNAs." @default.
- W4387377002 created "2023-10-06" @default.
- W4387377002 creator A5018387231 @default.
- W4387377002 creator A5042899064 @default.
- W4387377002 creator A5047311688 @default.
- W4387377002 creator A5048106842 @default.
- W4387377002 creator A5048384241 @default.
- W4387377002 creator A5062253129 @default.
- W4387377002 creator A5071796341 @default.
- W4387377002 creator A5075845857 @default.
- W4387377002 creator A5085754881 @default.
- W4387377002 creator A5089086405 @default.
- W4387377002 creator A5089343712 @default.
- W4387377002 creator A5092064997 @default.
- W4387377002 creator A5093010818 @default.
- W4387377002 date "2023-10-01" @default.
- W4387377002 modified "2023-10-18" @default.
- W4387377002 title "Universal features of Nsp1-mediated translational shutdown by coronaviruses" @default.
- W4387377002 cites W1803102843 @default.
- W4387377002 cites W1970611074 @default.
- W4387377002 cites W1977865284 @default.
- W4387377002 cites W1987068563 @default.
- W4387377002 cites W1994619478 @default.
- W4387377002 cites W2009239461 @default.
- W4387377002 cites W2034199961 @default.
- W4387377002 cites W2055526411 @default.
- W4387377002 cites W2079991169 @default.
- W4387377002 cites W2115854254 @default.
- W4387377002 cites W2119374287 @default.
- W4387377002 cites W2120772351 @default.
- W4387377002 cites W2124026197 @default.
- W4387377002 cites W2131409628 @default.
- W4387377002 cites W2154261378 @default.
- W4387377002 cites W2154714625 @default.
- W4387377002 cites W2155400685 @default.
- W4387377002 cites W2238516932 @default.
- W4387377002 cites W2275043758 @default.
- W4387377002 cites W2306794997 @default.
- W4387377002 cites W2538584349 @default.
- W4387377002 cites W2587625522 @default.
- W4387377002 cites W2593511418 @default.
- W4387377002 cites W2734356283 @default.
- W4387377002 cites W2739048070 @default.
- W4387377002 cites W2891167139 @default.
- W4387377002 cites W2898235321 @default.
- W4387377002 cites W2903899730 @default.
- W4387377002 cites W2949247954 @default.
- W4387377002 cites W2973457155 @default.
- W4387377002 cites W3001897055 @default.
- W4387377002 cites W3004280078 @default.
- W4387377002 cites W3009906937 @default.
- W4387377002 cites W3043427328 @default.
- W4387377002 cites W3049436672 @default.
- W4387377002 cites W3083393835 @default.
- W4387377002 cites W3083872269 @default.
- W4387377002 cites W3087744389 @default.
- W4387377002 cites W3092296275 @default.
- W4387377002 cites W3094854996 @default.
- W4387377002 cites W3107384990 @default.
- W4387377002 cites W3108368875 @default.
- W4387377002 cites W3111512297 @default.
- W4387377002 cites W3112131467 @default.
- W4387377002 cites W3126082010 @default.
- W4387377002 cites W3127173946 @default.
- W4387377002 cites W3131760520 @default.
- W4387377002 cites W3152730670 @default.
- W4387377002 cites W3162879212 @default.
- W4387377002 cites W3163640205 @default.
- W4387377002 cites W3168955085 @default.
- W4387377002 cites W3177828909 @default.
- W4387377002 cites W3202854217 @default.
- W4387377002 cites W4211091971 @default.
- W4387377002 cites W4214825390 @default.
- W4387377002 cites W4220653757 @default.
- W4387377002 cites W4226287839 @default.
- W4387377002 cites W4283259136 @default.
- W4387377002 doi "https://doi.org/10.1016/j.molcel.2023.09.002" @default.
- W4387377002 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37802027" @default.
- W4387377002 hasPublicationYear "2023" @default.
- W4387377002 type Work @default.
- W4387377002 citedByCount "0" @default.
- W4387377002 crossrefType "journal-article" @default.
- W4387377002 hasAuthorship W4387377002A5018387231 @default.
- W4387377002 hasAuthorship W4387377002A5042899064 @default.
- W4387377002 hasAuthorship W4387377002A5047311688 @default.
- W4387377002 hasAuthorship W4387377002A5048106842 @default.
- W4387377002 hasAuthorship W4387377002A5048384241 @default.
- W4387377002 hasAuthorship W4387377002A5062253129 @default.
- W4387377002 hasAuthorship W4387377002A5071796341 @default.
- W4387377002 hasAuthorship W4387377002A5075845857 @default.
- W4387377002 hasAuthorship W4387377002A5085754881 @default.
- W4387377002 hasAuthorship W4387377002A5089086405 @default.
- W4387377002 hasAuthorship W4387377002A5089343712 @default.
- W4387377002 hasAuthorship W4387377002A5092064997 @default.
- W4387377002 hasAuthorship W4387377002A5093010818 @default.
- W4387377002 hasBestOaLocation W43873770021 @default.
- W4387377002 hasConcept C104317684 @default.
- W4387377002 hasConcept C105580179 @default.