FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387380018> ?p ?o ?g. }

• W4387380018 abstract "Abstract Disclosure: K.M. Devon: None. A. Zahedi: None. A. Madani: None. J.D. Pasternak: None. B. Saravana-Bawan: None. A. Humar: None. T. Kathryn: None. While Halstead experimented with dog parathyroid transplantation, the first reported human parathyroid allotransplant appeared in the Annals of Surgery in 1911. Efforts of varying success in restoring calcium homeostasis in patients with refractory hypoparathyroidism after thyroidectomy have included parathyroid transplantation(tx), mainly in immunosuppressed kidney transplant recipients, using cryopreserved, cultured, or hypercellular tissues. Recently, cases of living-donor parathyroid allotransplants have been reported. We present a 46 year-old woman who developed hypoparathyroidism following total thyroidectomy 9 years prior. Treatment included two years of continuous teriparatide via CAD pump. Complications of portacath sepsis and pulmonary emboli, required intensive care. At the time of transplantation, our patient was taking elemental calcium 16 grams daily, magnesium 12 grams daily, calcitriol 8 ug daily, hydroochlorothiazide 25 mg twice daily, and nonetheless requiring biweekly intravenous calcium for symptoms and Calcium levels of 1.6 mmol/l (2.2-2.6 mmol/L). PTH ranged between 0.6- 1.2 pmol/l with poor quality of life. A medically suitable neurologically deceased donor was identified through the provincial organ donation organization. Her cumulative cPRA was 98% (Class I-95%/II-81%). Virtual crossmatch only positive for DQ2 specificity with weak positive B-cell flow crossmatch. Four healthy parathyroids were retrieved. The tissue was minced and placed into pockets in the recipient’s right brachioradialis muscle, under local anaesthesia with sedation. Ischemic time was 2.5 hours. She was induced with basiliximab and received tacrolimus, mycophenolate, and prednisone as immunotherapy. Evidence of biochemical parathyroid function was present post-tx day 9, and she was weaned off all calcium homeostatic medications by day 35, remaining asymptomatic at 7 months at the time of writing, with no calcium infusions. Self-reported quality of life is significantly improved. PTH 0.8-2.8 pmol/L and Calcium 2.06-2.37 mmol/l. To our knowledge this is the first successful fresh normal tissue deceased donor parathyroid transplant in a non-transplant recipient in North America. One study suggests that despite immunosuppression risks, 14 percent of patients would entertain parathyroid allotransplantation. We are currently recruiting additional patients with the aim of demonstrating that deceased donor parathyroid allotransplant using fresh tissue and immunosuppression is a novel viable and curative approach to treat permanent severe hypoparathyroidism. Presentation: Saturday, June 17, 2023" @default.
• W4387380018 created "2023-10-06" @default.
• W4387380018 creator A5011382706 @default.
• W4387380018 creator A5040623730 @default.
• W4387380018 creator A5047041683 @default.
• W4387380018 creator A5054045755 @default.
• W4387380018 creator A5064067196 @default.
• W4387380018 creator A5071634588 @default.
• W4387380018 creator A5079920843 @default.
• W4387380018 date "2023-10-01" @default.
• W4387380018 modified "2023-10-16" @default.
• W4387380018 title "SAT239 Deceased Donor Parathyroid Allotransplant For Sever Refractory Iatrogenic Hypoparathyroidism" @default.
• W4387380018 doi "https://doi.org/10.1210/jendso/bvad114.535" @default.
• W4387380018 hasPublicationYear "2023" @default.
• W4387380018 type Work @default.
• W4387380018 citedByCount "0" @default.
• W4387380018 crossrefType "journal-article" @default.
• W4387380018 hasAuthorship W4387380018A5011382706 @default.
• W4387380018 hasAuthorship W4387380018A5040623730 @default.
• W4387380018 hasAuthorship W4387380018A5047041683 @default.
• W4387380018 hasAuthorship W4387380018A5054045755 @default.
• W4387380018 hasAuthorship W4387380018A5064067196 @default.
• W4387380018 hasAuthorship W4387380018A5071634588 @default.
• W4387380018 hasAuthorship W4387380018A5079920843 @default.
• W4387380018 hasBestOaLocation W43873800181 @default.
• W4387380018 hasConcept C121332964 @default.
• W4387380018 hasConcept C126322002 @default.
• W4387380018 hasConcept C126894567 @default.
• W4387380018 hasConcept C141071460 @default.
• W4387380018 hasConcept C142424586 @default.
• W4387380018 hasConcept C2775941721 @default.
• W4387380018 hasConcept C2777074255 @default.
• W4387380018 hasConcept C2781208988 @default.
• W4387380018 hasConcept C2911091166 @default.
• W4387380018 hasConcept C519063684 @default.
• W4387380018 hasConcept C526584372 @default.
• W4387380018 hasConcept C71924100 @default.
• W4387380018 hasConcept C87355193 @default.
• W4387380018 hasConceptScore W4387380018C121332964 @default.
• W4387380018 hasConceptScore W4387380018C126322002 @default.
• W4387380018 hasConceptScore W4387380018C126894567 @default.
• W4387380018 hasConceptScore W4387380018C141071460 @default.
• W4387380018 hasConceptScore W4387380018C142424586 @default.
• W4387380018 hasConceptScore W4387380018C2775941721 @default.
• W4387380018 hasConceptScore W4387380018C2777074255 @default.
• W4387380018 hasConceptScore W4387380018C2781208988 @default.
• W4387380018 hasConceptScore W4387380018C2911091166 @default.
• W4387380018 hasConceptScore W4387380018C519063684 @default.
• W4387380018 hasConceptScore W4387380018C526584372 @default.
• W4387380018 hasConceptScore W4387380018C71924100 @default.
• W4387380018 hasConceptScore W4387380018C87355193 @default.
• W4387380018 hasIssue "Supplement_1" @default.
• W4387380018 hasLocation W43873800181 @default.
• W4387380018 hasOpenAccess W4387380018 @default.
• W4387380018 hasPrimaryLocation W43873800181 @default.
• W4387380018 hasRelatedWork W1980815605 @default.
• W4387380018 hasRelatedWork W2094123211 @default.
• W4387380018 hasRelatedWork W2106061149 @default.
• W4387380018 hasRelatedWork W2409316565 @default.
• W4387380018 hasRelatedWork W2425484112 @default.
• W4387380018 hasRelatedWork W2620477008 @default.
• W4387380018 hasRelatedWork W2751210218 @default.
• W4387380018 hasRelatedWork W3009665411 @default.
• W4387380018 hasRelatedWork W4306700227 @default.
• W4387380018 hasRelatedWork W4311352034 @default.
• W4387380018 hasVolume "7" @default.
• W4387380018 isParatext "false" @default.
• W4387380018 isRetracted "false" @default.
• W4387380018 workType "article" @default.