FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387380052> ?p ?o ?g. }

• W4387380052 abstract "Abstract Disclosure: N. Ding: None. Y. Mok: None. M. Salameh: None. W. Tang: None. E. Selvin: None. K.R. Butler: None. K. Matsushita: None. Introduction: Nontraumatic lower-extremity amputation (NLEA) is mainly caused by diabetes and peripheral artery disease. Although the annual incidence of NLEA is generally well-documented, no lifetime risk estimates are currently available. Furthermore, it is unknown whether the estimates vary by sociodemographic characteristics. Methods: In 14,108 ARIC participants aged 45-64 at baseline (1987-89), we estimated the cumulative incidence of NLEA (identified from discharge ICD codes) in the lifespan from age 50 through 80 using Fine and Gray’s proportional subhazards models accounting for the competing risk of death. We also explored the lifetime risk of NLEA by sex, race, annual household income, and in participants with diabetes. Additionally, we estimated the cumulative mortality among participants with and without NLEA using Kaplan-Meier analysis, in the scheme of a 1:2 matched cohort study. Results: There were 226 NLEA cases during a median follow-up time of 30 years. The estimated overall lifetime risk of NLEA from 50 years of age was 1.5% (95% confidence interval [CI], 1.3%-1.7%). The lifetime risk was highest in Black men (4.2% [3.1%-5.5%]), followed by Black women (2.7% [2.1%-3.5%]), White men (1.1% [0.8%-1.5%]), and White women (0.7% [0.5%-0.9%]). When further categorized by income, Black men with low income showed the highest lifetime risk (5.2% [3.7%-7.0%]), while White men with high income had a lifetime risk of 0.9% (0.6%-1.2%). Diabetes drastically increased the risk of NLEA by 5-fold in each race-sex group. Black men with diabetes have a 14% risk of developing NLEA in their lifetime. In the matched cohort study, we included 225 participants with NLEA and 450 without NLEA. The 1-year mortality was 30.9% (25.3%-37.4%) among those with NLEA and 4.1% (2.6%-6.4%) among those without NLEA, while the 10-year mortality was 83.5% (77.7%-88.6%) among those with NLEA and 38.9% (34.2%-44.1%) among those without. Conclusions: In this community-based cohort, 3%-4% of Black individuals experienced NLEA during their lifetime, while 1% of White individuals did. The lifetime risk was enhanced in people with low income and diabetes. Those with NLEA had greater short-term and long-term mortality than those without. Future public health efforts to prevent limb loss should prioritize racial minorities, those with low socioeconomic status, and diabetes. Presentation: Friday, June 16, 2023" @default.
• W4387380052 created "2023-10-06" @default.
• W4387380052 creator A5026446943 @default.
• W4387380052 creator A5029600723 @default.
• W4387380052 creator A5053982667 @default.
• W4387380052 creator A5063972278 @default.
• W4387380052 creator A5081148695 @default.
• W4387380052 creator A5081620371 @default.
• W4387380052 creator A5086558284 @default.
• W4387380052 date "2023-10-01" @default.
• W4387380052 modified "2023-10-16" @default.
• W4387380052 title "FRI618 Lifetime Risk Of Nontraumatic Lower-extremity Amputation" @default.
• W4387380052 doi "https://doi.org/10.1210/jendso/bvad114.840" @default.
• W4387380052 hasPublicationYear "2023" @default.
• W4387380052 type Work @default.
• W4387380052 citedByCount "0" @default.
• W4387380052 crossrefType "journal-article" @default.
• W4387380052 hasAuthorship W4387380052A5026446943 @default.
• W4387380052 hasAuthorship W4387380052A5029600723 @default.
• W4387380052 hasAuthorship W4387380052A5053982667 @default.
• W4387380052 hasAuthorship W4387380052A5063972278 @default.
• W4387380052 hasAuthorship W4387380052A5081148695 @default.
• W4387380052 hasAuthorship W4387380052A5081620371 @default.
• W4387380052 hasAuthorship W4387380052A5086558284 @default.
• W4387380052 hasBestOaLocation W43873800521 @default.
• W4387380052 hasConcept C120665830 @default.
• W4387380052 hasConcept C121332964 @default.
• W4387380052 hasConcept C126322002 @default.
• W4387380052 hasConcept C134018914 @default.
• W4387380052 hasConcept C141071460 @default.
• W4387380052 hasConcept C144024400 @default.
• W4387380052 hasConcept C149923435 @default.
• W4387380052 hasConcept C201903717 @default.
• W4387380052 hasConcept C2776204877 @default.
• W4387380052 hasConcept C2776210653 @default.
• W4387380052 hasConcept C44249647 @default.
• W4387380052 hasConcept C555293320 @default.
• W4387380052 hasConcept C61511704 @default.
• W4387380052 hasConcept C71924100 @default.
• W4387380052 hasConcept C72563966 @default.
• W4387380052 hasConcept C88879693 @default.
• W4387380052 hasConceptScore W4387380052C120665830 @default.
• W4387380052 hasConceptScore W4387380052C121332964 @default.
• W4387380052 hasConceptScore W4387380052C126322002 @default.
• W4387380052 hasConceptScore W4387380052C134018914 @default.
• W4387380052 hasConceptScore W4387380052C141071460 @default.
• W4387380052 hasConceptScore W4387380052C144024400 @default.
• W4387380052 hasConceptScore W4387380052C149923435 @default.
• W4387380052 hasConceptScore W4387380052C201903717 @default.
• W4387380052 hasConceptScore W4387380052C2776204877 @default.
• W4387380052 hasConceptScore W4387380052C2776210653 @default.
• W4387380052 hasConceptScore W4387380052C44249647 @default.
• W4387380052 hasConceptScore W4387380052C555293320 @default.
• W4387380052 hasConceptScore W4387380052C61511704 @default.
• W4387380052 hasConceptScore W4387380052C71924100 @default.
• W4387380052 hasConceptScore W4387380052C72563966 @default.
• W4387380052 hasConceptScore W4387380052C88879693 @default.
• W4387380052 hasIssue "Supplement_1" @default.
• W4387380052 hasLocation W43873800521 @default.
• W4387380052 hasOpenAccess W4387380052 @default.
• W4387380052 hasPrimaryLocation W43873800521 @default.
• W4387380052 hasRelatedWork W1965104097 @default.
• W4387380052 hasRelatedWork W2070776487 @default.
• W4387380052 hasRelatedWork W2084210605 @default.
• W4387380052 hasRelatedWork W2134528313 @default.
• W4387380052 hasRelatedWork W2364863060 @default.
• W4387380052 hasRelatedWork W2416450202 @default.
• W4387380052 hasRelatedWork W2418966622 @default.
• W4387380052 hasRelatedWork W2474099925 @default.
• W4387380052 hasRelatedWork W3005882639 @default.
• W4387380052 hasRelatedWork W53984234 @default.
• W4387380052 hasVolume "7" @default.
• W4387380052 isParatext "false" @default.
• W4387380052 isRetracted "false" @default.
• W4387380052 workType "article" @default.