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- W4387380672 abstract "Abstract Metabolic profiling offers huge potential to highlight markers and mechanisms in support of toxicology and pathology investigations during drug development. The main objective was to modify therapy with adamantane derivatives: amantadine and rimantadine, to increase their bioavailability and evaluate the influence of such therapy on drug metabolism using Saccharomyces cerevisiae as the model organism. In this study, the profile of endogenous metabolites of a model organism was measured and interpreted to provide an opportunity to investigate changes induced by treatment with amantadine and rimantadine. It was found that resveratrol supplementation synergistically enhanced the effects of amantadine treatment and increased rimantadine metabolism, potentially reducing side effects. The fingerprinting strategy was used as an efficient technique for qualitatively evaluating and monitoring changes in the profiles of endogenous components and their contents in a model organism. Chemometric tools were employed to find marker compounds that can be defined as characteristic indicators of a pharmacological response to a therapeutic intervention. An improved understanding of the mechanisms involved in drug effect and an increased ability to predict individual variations in the drug response of organisms will improve the treatment process and the development of new therapies." @default.
- W4387380672 created "2023-10-06" @default.
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- W4387380672 date "2023-10-05" @default.
- W4387380672 modified "2023-10-18" @default.
- W4387380672 title "Metabolic profiling to evaluate the impact of amantadine and rimantadine on the secondary metabolism of a model organism" @default.
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- W4387380672 doi "https://doi.org/10.1038/s41598-023-43540-w" @default.
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