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- W4387380750 abstract "Abstract Purpose To construct radiomics models based on MRI at different time points for the early prediction of cystic brain radionecrosis (CBRN) for nasopharyngeal carcinoma (NPC). Methods A total of 202 injured temporal lobes from 155 NPC patients with radiotherapy-induced temporal lobe injury (RTLI) after intensity modulated radiotherapy (IMRT) were included in the study. All the injured lobes were randomly divided into the training (n = 143) and validation (n = 59) sets. Radiomics models were constructed by using features extracted from T2WI at two different time points: at the end of IMRT (post-IMRT) and the first-detected RTLI (first-RTLI). A delta-radiomics feature was defined as the percentage change in a radiomics feature from post-IMRT to first-RTLI. The radiomics nomogram was constructed by combining clinical risk factors and radiomics signatures using multivariate logistic regression analysis. Predictive performance was evaluated using receiver operating characteristic analysis, and the area under the curve (AUC) values of the different models were compared by DeLong test. Results The post-IMRT, first-RTLI, and delta-radiomics models yielded AUC values of 0.84 (95% CI: 0.76–0.92), 0.86 (95% CI: 0.78–0.94), and 0.77 (95% CI: 0.67–0.87), respectively. The nomogram, which combined the history of drinking, post-IMRT, first-RTLI, and delta-radscores, exhibited the highest AUC of 0.91 (95% CI: 0.85–0.97) compared to any single radiomics model. However, there were no statistically significant differences observed between the nomogram and post-IMRT radiomics model, as well as between the nomogram and first-RTLI radiomics model. Conclusion MRI-based radiomics model may be helpful to predict CBRN in advance as early as at the end of IMRT for NPC patients." @default.
- W4387380750 created "2023-10-06" @default.
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- W4387380750 date "2023-10-05" @default.
- W4387380750 modified "2023-10-16" @default.
- W4387380750 title "MRI-based radiomics models predict cystic brain radionecrosis of nasopharyngeal carcinoma after intensity modulated radiotherapy" @default.
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- W4387380750 doi "https://doi.org/10.21203/rs.3.rs-3392308/v1" @default.
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