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- W4387384376 abstract "Genes related to the circadian rhythm control various biological processes. The aim of this study was to comprehensively investigate the mutational and mRNA profile of core circadian rhythm genes in hepatocellular cancer (HCC) samples.In this study, the gene profile of a total of 369 patients with HCC was examined over the data obtained from the cancer genome atlas database through-cBioPortal. The effects of mutations on protein were examined by scoring the Polymorphism Phenotyping v2, Mutation Assessor, and SIFT-databases. While the association of genes with other genes was determined with the GeneMANIA-database, the association of expression levels in the genes with overall survival (OS) was evaluated with the Kaplan-Meier Plot database.As a result of the analyses, there were a total of 25 mutations. Decreased expression levels of PER1 (1.3e-05), PER3 (p=0.046), and CRY2 (p=1.8e-06) genes were found statistically associated with shorter OS. It was also found that increased expression levels of the PER2 (p=0.045) gene were associated with longer OS, and increased expression levels of the NPAS2 (p=9e-04) gene were associated with shorter OS.In particular, changes in the PER1, PER2, CRY2, and NPAS2 genes may provide possible molecular targets in chemotherapy and immunotherapy for HCC patients." @default.
- W4387384376 created "2023-10-06" @default.
- W4387384376 creator A5068048464 @default.
- W4387384376 date "2023-01-01" @default.
- W4387384376 modified "2023-10-14" @default.
- W4387384376 title "Bioinformatic Analysis of Genetic Changes CLOCK, BMAL1, CRY1, CRY2, PER1, PER2, PER3 and NPAS2 Proteins in HCC Patients" @default.
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- W4387384376 doi "https://doi.org/10.14744/hf.2023.2023.0009" @default.
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