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- W4387391954 abstract "Abstract A library of 3‐aryl‐3‐azetidinyl acetic acid methyl ester derivatives was prepared from N ‐Boc‐3‐azetidinone employing the Horner‐Wadsworth‐Emmons reaction, rhodium(I)‐catalyzed conjugate addition of arylboronic acids, and subsequent elaborations to obtain N ‐unprotected hydrochlorides, N ‐alkylated and N ‐acylated azetidine derivatives. The compounds were evaluated for acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activity, revealing several derivatives to possess AChE inhibition comparable to that of the AChE inhibitor rivastigmine. The binding mode of the AChE inhibitor donepezil and selected active compounds 26 and 27 within the active site of AChE was studied using molecular docking. Furthermore, the neuroprotective activity of the prepared compounds was evaluated in models associated with Parkinson's disease (salsolinol‐induced) and aspects of Alzheimer's disease (glutamate‐induced oxidative damage). Compound 28 showed the highest neuroprotective effect in both salsolinol‐ and glutamate‐induced neurodegeneration models, and its protective effect in the glutamate model was revealed to be driven by a reduction in oxidative stress and caspase‐3/7 activity." @default.
- W4387391954 created "2023-10-07" @default.
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- W4387391954 date "2023-10-05" @default.
- W4387391954 modified "2023-10-17" @default.
- W4387391954 title "Synthesis and neuroprotective activity of 3‐aryl‐3‐azetidinyl acetic acid methyl ester derivatives" @default.
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- W4387391954 cites W1963844828 @default.
- W4387391954 cites W1964006025 @default.
- W4387391954 cites W1973975403 @default.
- W4387391954 cites W1979883589 @default.
- W4387391954 cites W1980538363 @default.
- W4387391954 cites W1987204546 @default.
- W4387391954 cites W1987693723 @default.
- W4387391954 cites W2019720355 @default.
- W4387391954 cites W2033863809 @default.
- W4387391954 cites W2034471624 @default.
- W4387391954 cites W2042684411 @default.
- W4387391954 cites W2044952183 @default.
- W4387391954 cites W2052424978 @default.
- W4387391954 cites W2053518172 @default.
- W4387391954 cites W2054966297 @default.
- W4387391954 cites W2054979333 @default.
- W4387391954 cites W2058517643 @default.
- W4387391954 cites W2059338495 @default.
- W4387391954 cites W2066473885 @default.
- W4387391954 cites W2069666032 @default.
- W4387391954 cites W2083630161 @default.
- W4387391954 cites W2092814331 @default.
- W4387391954 cites W2095519326 @default.
- W4387391954 cites W2097724095 @default.
- W4387391954 cites W2110044349 @default.
- W4387391954 cites W2112455323 @default.
- W4387391954 cites W2130158865 @default.
- W4387391954 cites W2142587255 @default.
- W4387391954 cites W2147591077 @default.
- W4387391954 cites W2151027049 @default.
- W4387391954 cites W2155162140 @default.
- W4387391954 cites W2159838014 @default.
- W4387391954 cites W2169399656 @default.
- W4387391954 cites W2171288844 @default.
- W4387391954 cites W2191791205 @default.
- W4387391954 cites W2291203742 @default.
- W4387391954 cites W2407040666 @default.
- W4387391954 cites W2528307646 @default.
- W4387391954 cites W2539097406 @default.
- W4387391954 cites W2549428458 @default.
- W4387391954 cites W2568450381 @default.
- W4387391954 cites W2593118895 @default.
- W4387391954 cites W2609798299 @default.
- W4387391954 cites W2610740017 @default.
- W4387391954 cites W2612436868 @default.
- W4387391954 cites W2702684814 @default.
- W4387391954 cites W2766260610 @default.
- W4387391954 cites W2769028278 @default.
- W4387391954 cites W2770761409 @default.
- W4387391954 cites W2781751987 @default.
- W4387391954 cites W2805588862 @default.
- W4387391954 cites W2807594241 @default.
- W4387391954 cites W2902568343 @default.
- W4387391954 cites W2908372645 @default.
- W4387391954 cites W2950459976 @default.
- W4387391954 cites W2955852147 @default.
- W4387391954 cites W2960505072 @default.
- W4387391954 cites W2965717703 @default.
- W4387391954 cites W2967776243 @default.
- W4387391954 cites W2976176226 @default.
- W4387391954 cites W2989944833 @default.
- W4387391954 cites W3042624831 @default.
- W4387391954 cites W3095050113 @default.
- W4387391954 cites W3096318447 @default.
- W4387391954 cites W3112506438 @default.
- W4387391954 cites W3118686717 @default.
- W4387391954 cites W3118718841 @default.
- W4387391954 cites W3158049093 @default.
- W4387391954 cites W3158545443 @default.
- W4387391954 cites W3174798325 @default.
- W4387391954 cites W3190609919 @default.
- W4387391954 cites W3213669997 @default.
- W4387391954 cites W3216402819 @default.
- W4387391954 cites W4205697898 @default.
- W4387391954 cites W4239872781 @default.
- W4387391954 cites W4248650858 @default.
- W4387391954 cites W4289745901 @default.
- W4387391954 cites W4296886875 @default.
- W4387391954 cites W4317721491 @default.
- W4387391954 doi "https://doi.org/10.1002/ardp.202300378" @default.
- W4387391954 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37797174" @default.