FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387392008> ?p ?o ?g. }

• W4387392008 abstract "Abstract Background BRD4, belonging to the bromodomain extra‐terminal (BET) protein family, plays a unique role in tumor progression. However, the potential impact of BRD4 in ameloblastoma (AM) remains largely unknown. Herein, we aimed to assess the expression and functional role of BRD4 in AM. Methods The expression level of BRD4 was assessed by immunohistochemistry. The proliferation, migration, invasion, and tumorigenic abilities of AM cells were assessed by a series of assays. To explore the molecular expression profile of BRD4‐depleted AM cells, RNA sequencing (RNA‐seq) was performed. Bioinformatic analysis was performed on AM expression matrices obtained from the Gene Expression Omnibus (GEO). The therapeutic efficacy of BET‐inhibitors (BETi) was assessed with AM patient‐derived organoids. Results Upregulation of BRD4 was observed in conventional AMs, recurrent AMs, and ameloblastic carcinomas. Depletion of BRD4 inhibited proliferation, invasion, migration, and tumorigenesis in AM. Administration of BETi attenuated the aggressiveness of AM and the growth of AM patient‐derived organoids. Bioinformatic analysis indicated that BRD4 may promote AM progression by regulating the Wnt pathway and stemness‐associated pathways. Conclusion BRD4 increases the aggressiveness and promotes the recurrence of ameloblastoma by regulating the Wnt pathway and stemness‐associated pathways. These findings highlight BRD4 as a promising therapeutic target in AM management." @default.
• W4387392008 created "2023-10-07" @default.
• W4387392008 creator A5005938047 @default.
• W4387392008 creator A5006371274 @default.
• W4387392008 creator A5008966262 @default.
• W4387392008 creator A5009035495 @default.
• W4387392008 creator A5018393711 @default.
• W4387392008 creator A5043345052 @default.
• W4387392008 creator A5046982193 @default.
• W4387392008 creator A5071941735 @default.
• W4387392008 creator A5080733133 @default.
• W4387392008 creator A5081649991 @default.
• W4387392008 creator A5091839134 @default.
• W4387392008 date "2023-10-05" @default.
• W4387392008 modified "2023-10-07" @default.
• W4387392008 title "Targeting BRD4 attenuates the stemness and aggressiveness of ameloblastoma" @default.
• W4387392008 cites W1524280083 @default.
• W4387392008 cites W1802273768 @default.
• W4387392008 cites W1965596509 @default.
• W4387392008 cites W1997087919 @default.
• W4387392008 cites W2009561580 @default.
• W4387392008 cites W2013376286 @default.
• W4387392008 cites W2027773301 @default.
• W4387392008 cites W2041653784 @default.
• W4387392008 cites W2044394552 @default.
• W4387392008 cites W2057460011 @default.
• W4387392008 cites W2072591861 @default.
• W4387392008 cites W2106446134 @default.
• W4387392008 cites W2113471107 @default.
• W4387392008 cites W2130017969 @default.
• W4387392008 cites W2136868885 @default.
• W4387392008 cites W2145754223 @default.
• W4387392008 cites W2157222945 @default.
• W4387392008 cites W2282572028 @default.
• W4387392008 cites W2401142345 @default.
• W4387392008 cites W2469751207 @default.
• W4387392008 cites W2583984560 @default.
• W4387392008 cites W2754574141 @default.
• W4387392008 cites W2903414920 @default.
• W4387392008 cites W3000011351 @default.
• W4387392008 cites W3008158397 @default.
• W4387392008 cites W3131798300 @default.
• W4387392008 cites W3137545349 @default.
• W4387392008 cites W3161172741 @default.
• W4387392008 cites W3166464287 @default.
• W4387392008 cites W3207845424 @default.
• W4387392008 cites W4286111725 @default.
• W4387392008 cites W4289525443 @default.
• W4387392008 doi "https://doi.org/10.1111/odi.14762" @default.
• W4387392008 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37798926" @default.
• W4387392008 hasPublicationYear "2023" @default.
• W4387392008 type Work @default.
• W4387392008 citedByCount "0" @default.
• W4387392008 crossrefType "journal-article" @default.
• W4387392008 hasAuthorship W4387392008A5005938047 @default.
• W4387392008 hasAuthorship W4387392008A5006371274 @default.
• W4387392008 hasAuthorship W4387392008A5008966262 @default.
• W4387392008 hasAuthorship W4387392008A5009035495 @default.
• W4387392008 hasAuthorship W4387392008A5018393711 @default.
• W4387392008 hasAuthorship W4387392008A5043345052 @default.
• W4387392008 hasAuthorship W4387392008A5046982193 @default.
• W4387392008 hasAuthorship W4387392008A5071941735 @default.
• W4387392008 hasAuthorship W4387392008A5080733133 @default.
• W4387392008 hasAuthorship W4387392008A5081649991 @default.
• W4387392008 hasAuthorship W4387392008A5091839134 @default.
• W4387392008 hasConcept C104317684 @default.
• W4387392008 hasConcept C121608353 @default.
• W4387392008 hasConcept C122246415 @default.
• W4387392008 hasConcept C126322002 @default.
• W4387392008 hasConcept C127561419 @default.
• W4387392008 hasConcept C137620995 @default.
• W4387392008 hasConcept C199343813 @default.
• W4387392008 hasConcept C2775876115 @default.
• W4387392008 hasConcept C2779634854 @default.
• W4387392008 hasConcept C28328180 @default.
• W4387392008 hasConcept C41091548 @default.
• W4387392008 hasConcept C502942594 @default.
• W4387392008 hasConcept C54355233 @default.
• W4387392008 hasConcept C555283112 @default.
• W4387392008 hasConcept C62478195 @default.
• W4387392008 hasConcept C71924100 @default.
• W4387392008 hasConcept C74401373 @default.
• W4387392008 hasConcept C86803240 @default.
• W4387392008 hasConcept C95444343 @default.
• W4387392008 hasConceptScore W4387392008C104317684 @default.
• W4387392008 hasConceptScore W4387392008C121608353 @default.
• W4387392008 hasConceptScore W4387392008C122246415 @default.
• W4387392008 hasConceptScore W4387392008C126322002 @default.
• W4387392008 hasConceptScore W4387392008C127561419 @default.
• W4387392008 hasConceptScore W4387392008C137620995 @default.
• W4387392008 hasConceptScore W4387392008C199343813 @default.
• W4387392008 hasConceptScore W4387392008C2775876115 @default.
• W4387392008 hasConceptScore W4387392008C2779634854 @default.
• W4387392008 hasConceptScore W4387392008C28328180 @default.
• W4387392008 hasConceptScore W4387392008C41091548 @default.
• W4387392008 hasConceptScore W4387392008C502942594 @default.
• W4387392008 hasConceptScore W4387392008C54355233 @default.
• W4387392008 hasConceptScore W4387392008C555283112 @default.
• W4387392008 hasConceptScore W4387392008C62478195 @default.
• W4387392008 hasConceptScore W4387392008C71924100 @default.

• next