FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387392336> ?p ?o ?g. }

• W4387392336 abstract "ABSTRACT One of the major contributors to child mortality in the world is diarrheal diseases, with an estimated 800,000 deaths per year. Many pathogens are causative agents of these illnesses, including the enteropathogenic or enterohemorrhagic forms of Escherichia coli . These bacteria are characterized by their ability to cause attaching and effacing lesions in the gut mucosa. Although much has been learned about the pathogenicity of these organisms and the immune response against them, the role of the intestinal microbiota during these infections is not well characterized. Infection of mice with E. coli requires pre-treatment with antibiotics in most mouse models, which hinders the study of the microbiota in an undisturbed environment. Using Citrobacter rodentium as a murine model for attaching and effacing bacteria, we show that C57BL/6 mice deficient in granzyme B expression are highly susceptible to severe disease caused by C. rodentium infection. Although a previous publication from our group shows that granzyme B-deficient CD4 + T cells are partially responsible for this phenotype, in this report, we present data demonstrating that the microbiota, in particular members of the order Turicibacterales, have an important role in conferring resistance. Mice deficient in Turicibacter sanguinis have increased susceptibility to severe disease. However, when these mice are co-housed with resistant mice or colonized with T. sanguinis , susceptibility to severe infection is reduced. These results clearly suggest a critical role for this commensal in the protection against enteropathogens." @default.
• W4387392336 created "2023-10-07" @default.
• W4387392336 creator A5000074569 @default.
• W4387392336 creator A5009306547 @default.
• W4387392336 creator A5016967871 @default.
• W4387392336 creator A5027146256 @default.
• W4387392336 creator A5029984520 @default.
• W4387392336 creator A5036231550 @default.
• W4387392336 creator A5038360456 @default.
• W4387392336 creator A5049202342 @default.
• W4387392336 creator A5080995308 @default.
• W4387392336 date "2023-10-06" @default.
• W4387392336 modified "2023-10-17" @default.
• W4387392336 title "Turicibacterales protect mice from severe <i>Citrobacter rodentium</i> infection" @default.
• W4387392336 cites W1825962579 @default.
• W4387392336 cites W1902385211 @default.
• W4387392336 cites W2005879027 @default.
• W4387392336 cites W2033386838 @default.
• W4387392336 cites W2065231269 @default.
• W4387392336 cites W2080475118 @default.
• W4387392336 cites W2107066107 @default.
• W4387392336 cites W2107369528 @default.
• W4387392336 cites W2111210489 @default.
• W4387392336 cites W2114053580 @default.
• W4387392336 cites W2119259412 @default.
• W4387392336 cites W2122796622 @default.
• W4387392336 cites W2138738692 @default.
• W4387392336 cites W2155997615 @default.
• W4387392336 cites W2162976482 @default.
• W4387392336 cites W2169910756 @default.
• W4387392336 cites W2197849900 @default.
• W4387392336 cites W2309720534 @default.
• W4387392336 cites W2327893676 @default.
• W4387392336 cites W2345813655 @default.
• W4387392336 cites W2564755845 @default.
• W4387392336 cites W2677397198 @default.
• W4387392336 cites W2922756476 @default.
• W4387392336 cites W2971786247 @default.
• W4387392336 cites W2974493130 @default.
• W4387392336 cites W2982566732 @default.
• W4387392336 cites W3007149015 @default.
• W4387392336 cites W3012466670 @default.
• W4387392336 cites W3034922513 @default.
• W4387392336 cites W3044979755 @default.
• W4387392336 cites W3111684205 @default.
• W4387392336 cites W3173154121 @default.
• W4387392336 cites W3187884260 @default.
• W4387392336 cites W3193361577 @default.
• W4387392336 cites W3199249615 @default.
• W4387392336 cites W3212327146 @default.
• W4387392336 cites W4210733056 @default.
• W4387392336 cites W4283707658 @default.
• W4387392336 cites W4320493720 @default.
• W4387392336 doi "https://doi.org/10.1128/iai.00322-23" @default.
• W4387392336 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37800916" @default.
• W4387392336 hasPublicationYear "2023" @default.
• W4387392336 type Work @default.
• W4387392336 citedByCount "0" @default.
• W4387392336 crossrefType "journal-article" @default.
• W4387392336 hasAuthorship W4387392336A5000074569 @default.
• W4387392336 hasAuthorship W4387392336A5009306547 @default.
• W4387392336 hasAuthorship W4387392336A5016967871 @default.
• W4387392336 hasAuthorship W4387392336A5027146256 @default.
• W4387392336 hasAuthorship W4387392336A5029984520 @default.
• W4387392336 hasAuthorship W4387392336A5036231550 @default.
• W4387392336 hasAuthorship W4387392336A5038360456 @default.
• W4387392336 hasAuthorship W4387392336A5049202342 @default.
• W4387392336 hasAuthorship W4387392336A5080995308 @default.
• W4387392336 hasConcept C104317684 @default.
• W4387392336 hasConcept C167672396 @default.
• W4387392336 hasConcept C203014093 @default.
• W4387392336 hasConcept C2775945818 @default.
• W4387392336 hasConcept C2778910516 @default.
• W4387392336 hasConcept C2780380082 @default.
• W4387392336 hasConcept C2910319489 @default.
• W4387392336 hasConcept C2910478007 @default.
• W4387392336 hasConcept C547475151 @default.
• W4387392336 hasConcept C55493867 @default.
• W4387392336 hasConcept C86803240 @default.
• W4387392336 hasConcept C8891405 @default.
• W4387392336 hasConcept C89423630 @default.
• W4387392336 hasConceptScore W4387392336C104317684 @default.
• W4387392336 hasConceptScore W4387392336C167672396 @default.
• W4387392336 hasConceptScore W4387392336C203014093 @default.
• W4387392336 hasConceptScore W4387392336C2775945818 @default.
• W4387392336 hasConceptScore W4387392336C2778910516 @default.
• W4387392336 hasConceptScore W4387392336C2780380082 @default.
• W4387392336 hasConceptScore W4387392336C2910319489 @default.
• W4387392336 hasConceptScore W4387392336C2910478007 @default.
• W4387392336 hasConceptScore W4387392336C547475151 @default.
• W4387392336 hasConceptScore W4387392336C55493867 @default.
• W4387392336 hasConceptScore W4387392336C86803240 @default.
• W4387392336 hasConceptScore W4387392336C8891405 @default.
• W4387392336 hasConceptScore W4387392336C89423630 @default.
• W4387392336 hasFunder F4320337357 @default.
• W4387392336 hasLocation W43873923361 @default.
• W4387392336 hasLocation W43873923362 @default.
• W4387392336 hasOpenAccess W4387392336 @default.
• W4387392336 hasPrimaryLocation W43873923361 @default.
• W4387392336 hasRelatedWork W1573547148 @default.

• next