FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387392489> ?p ?o ?g. }

• W4387392489 abstract "Abstract Patients with cystic fibrosis (CF) exhibit pronounced respiratory damage and were initially considered among those at highest risk for serious harm from SARS‐CoV‐2 infection. Numerous clinical studies have subsequently reported that individuals with CF in North America and Europe—while susceptible to severe COVID‐19—are often spared from the highest levels of virus‐associated mortality. To understand features that might influence COVID‐19 among patients with cystic fibrosis, we studied relationships between SARS‐CoV‐2 and the gene responsible for CF (i.e., the cystic fibrosis transmembrane conductance regulator, CFTR). In contrast to previous reports, we found no association between CFTR carrier status (mutation heterozygosity) and more severe COVID‐19 clinical outcomes. We did observe an unexpected trend toward higher mortality among control individuals compared with silent carriers of the common F508del CFTR variant—a finding that will require further study. We next performed experiments to test the influence of homozygous CFTR deficiency on viral propagation and showed that SARS‐CoV‐2 production in primary airway cells was not altered by the absence of functional CFTR using two independent protocols. On the contrary, experiments performed in vitro strongly indicated that virus proliferation depended on features of the mucosal fluid layer known to be disrupted by absent CFTR in patients with CF, including both low pH and increased viscosity. These results point to the acidic, viscous, and mucus‐obstructed airways in patients with cystic fibrosis as unfavorable for the establishment of coronaviral infection. Our findings provide new and important information concerning relationships between the CF clinical phenotype and severity of COVID‐19." @default.
• W4387392489 created "2023-10-07" @default.
• W4387392489 creator A5002616480 @default.
• W4387392489 creator A5003241020 @default.
• W4387392489 creator A5007710796 @default.
• W4387392489 creator A5008555835 @default.
• W4387392489 creator A5010118231 @default.
• W4387392489 creator A5014252849 @default.
• W4387392489 creator A5018836842 @default.
• W4387392489 creator A5021950824 @default.
• W4387392489 creator A5024652585 @default.
• W4387392489 creator A5026193271 @default.
• W4387392489 creator A5031713882 @default.
• W4387392489 creator A5034354112 @default.
• W4387392489 creator A5037480677 @default.
• W4387392489 creator A5041223207 @default.
• W4387392489 creator A5046764809 @default.
• W4387392489 creator A5050497878 @default.
• W4387392489 creator A5050704941 @default.
• W4387392489 creator A5050971423 @default.
• W4387392489 creator A5051482861 @default.
• W4387392489 creator A5053165641 @default.
• W4387392489 creator A5054281430 @default.
• W4387392489 creator A5054601700 @default.
• W4387392489 creator A5056415017 @default.
• W4387392489 creator A5059930571 @default.
• W4387392489 creator A5061318749 @default.
• W4387392489 creator A5063716127 @default.
• W4387392489 creator A5065511179 @default.
• W4387392489 creator A5067310475 @default.
• W4387392489 creator A5072611099 @default.
• W4387392489 creator A5073345578 @default.
• W4387392489 creator A5073693721 @default.
• W4387392489 creator A5073716313 @default.
• W4387392489 creator A5084083958 @default.
• W4387392489 creator A5084110734 @default.
• W4387392489 creator A5084259836 @default.
• W4387392489 creator A5090016165 @default.
• W4387392489 creator A5091626287 @default.
• W4387392489 date "2023-10-06" @default.
• W4387392489 modified "2023-10-17" @default.
• W4387392489 title "Mechanisms by which the cystic fibrosis transmembrane conductance regulator may influence <scp>SARS‐CoV</scp>‐2 infection and <scp>COVID</scp>‐19 disease severity" @default.
• W4387392489 cites W1544320236 @default.
• W4387392489 cites W1592694746 @default.
• W4387392489 cites W1618797045 @default.
• W4387392489 cites W1647483410 @default.
• W4387392489 cites W1938632322 @default.
• W4387392489 cites W1966912799 @default.
• W4387392489 cites W1986162227 @default.
• W4387392489 cites W1986179737 @default.
• W4387392489 cites W1990301853 @default.
• W4387392489 cites W1991218513 @default.
• W4387392489 cites W1993407089 @default.
• W4387392489 cites W2002423049 @default.
• W4387392489 cites W2009788456 @default.
• W4387392489 cites W2019385365 @default.
• W4387392489 cites W2039462910 @default.
• W4387392489 cites W2042262223 @default.
• W4387392489 cites W2044380511 @default.
• W4387392489 cites W2049258023 @default.
• W4387392489 cites W2063315216 @default.
• W4387392489 cites W2068955142 @default.
• W4387392489 cites W2075390708 @default.
• W4387392489 cites W2084619830 @default.
• W4387392489 cites W2090601537 @default.
• W4387392489 cites W2094858676 @default.
• W4387392489 cites W2094992482 @default.
• W4387392489 cites W2104354608 @default.
• W4387392489 cites W2108013032 @default.
• W4387392489 cites W2134791291 @default.
• W4387392489 cites W2164652755 @default.
• W4387392489 cites W2253068377 @default.
• W4387392489 cites W2257896194 @default.
• W4387392489 cites W2270680140 @default.
• W4387392489 cites W2290472536 @default.
• W4387392489 cites W2293427089 @default.
• W4387392489 cites W2339032732 @default.
• W4387392489 cites W2469289450 @default.
• W4387392489 cites W2531363247 @default.
• W4387392489 cites W2595624224 @default.
• W4387392489 cites W2613319605 @default.
• W4387392489 cites W2755268241 @default.
• W4387392489 cites W2793332372 @default.
• W4387392489 cites W2809639193 @default.
• W4387392489 cites W2895592447 @default.
• W4387392489 cites W2948261226 @default.
• W4387392489 cites W2959501818 @default.
• W4387392489 cites W2980660958 @default.
• W4387392489 cites W2997710838 @default.
• W4387392489 cites W3001195213 @default.
• W4387392489 cites W3009912996 @default.
• W4387392489 cites W3011483298 @default.
• W4387392489 cites W3015751519 @default.
• W4387392489 cites W3016785135 @default.
• W4387392489 cites W3020087243 @default.
• W4387392489 cites W3030748957 @default.
• W4387392489 cites W3035115002 @default.
• W4387392489 cites W3036224708 @default.
• W4387392489 cites W3036391214 @default.
• W4387392489 cites W3036779511 @default.

• next