Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387392616> ?p ?o ?g. }
- W4387392616 abstract "Abstract The epidemic of Mpox virus (MPXV) from May 2022 was once declared as a Public Health Emergency of International Concern by the World Health Organization. Vaccines play an important role in prevention of infectious diseases, and mRNA vaccine technology was proved to be a safe and effective platform with successful application in defense of coronavirus disease 2019. In this study, based on A29L, M1R, A35R, and B6R of MPXV, we developed two MPXV mRNA vaccine candidates, designated as MPXfus and MPXmix. The MPXfus was one‐component, in which these four antigen proteins were linked in tandem by flexible linker and encoded by an individual mRNA as a fusion protein. The MPXmix was multicomponent containing four mRNA, and each mRNA encoded one antigen protein respectively. Mice were immunized with equal quality of MPXfus or MPXmix, delivered by lipid nanoparticles for evaluation and comparison of the immune responses induced by these two MPXV vaccine candidates. Results of immune response analyses indicated that both MPXfus and MPXmix could elicit high‐level of antigen‐specific antibodies and robust cellular immune response in mice. Moreover, results of virus neutralization assays suggested that sera from MPXfus‐ or MPXmix‐immunized mice possessed high neutralizing activities against vaccinia virus. In addition, titers of antigen‐specific antibody, levels of cellular immune response, and activities of neutralizing antibody against vaccinia virus induced by MPXfus and MPXmix presented no significant difference. In summary, this study provides valuable insights for further clinical development of one‐component and multicomponent mRNA vaccine candidates for the prevention of MPXV and other orthomyxoviruses." @default.
- W4387392616 created "2023-10-07" @default.
- W4387392616 creator A5009590736 @default.
- W4387392616 creator A5014367830 @default.
- W4387392616 creator A5015134471 @default.
- W4387392616 creator A5040720706 @default.
- W4387392616 creator A5044874432 @default.
- W4387392616 creator A5047011282 @default.
- W4387392616 creator A5047918553 @default.
- W4387392616 creator A5058506679 @default.
- W4387392616 creator A5069502084 @default.
- W4387392616 creator A5082483043 @default.
- W4387392616 creator A5090133014 @default.
- W4387392616 date "2023-10-01" @default.
- W4387392616 modified "2023-10-18" @default.
- W4387392616 title "Evaluation and comparison of immune responses induced by two Mpox mRNA vaccine candidates in mice" @default.
- W4387392616 cites W1970129342 @default.
- W4387392616 cites W1984263551 @default.
- W4387392616 cites W1994399275 @default.
- W4387392616 cites W1999300623 @default.
- W4387392616 cites W2008907215 @default.
- W4387392616 cites W2033629536 @default.
- W4387392616 cites W2042370230 @default.
- W4387392616 cites W2051619514 @default.
- W4387392616 cites W2054789512 @default.
- W4387392616 cites W2134161715 @default.
- W4387392616 cites W2136580520 @default.
- W4387392616 cites W2299075392 @default.
- W4387392616 cites W2532821028 @default.
- W4387392616 cites W2564477152 @default.
- W4387392616 cites W2989502228 @default.
- W4387392616 cites W3132054000 @default.
- W4387392616 cites W4225689052 @default.
- W4387392616 cites W4281252060 @default.
- W4387392616 cites W4281893638 @default.
- W4387392616 cites W4286383196 @default.
- W4387392616 cites W4292604339 @default.
- W4387392616 cites W4294637087 @default.
- W4387392616 cites W4306721676 @default.
- W4387392616 cites W4307446305 @default.
- W4387392616 cites W4310712811 @default.
- W4387392616 cites W4310938020 @default.
- W4387392616 cites W4318392033 @default.
- W4387392616 cites W4323921087 @default.
- W4387392616 cites W4353018871 @default.
- W4387392616 cites W4362660720 @default.
- W4387392616 cites W4367055021 @default.
- W4387392616 cites W4367312621 @default.
- W4387392616 cites W4375844485 @default.
- W4387392616 cites W4383646139 @default.
- W4387392616 doi "https://doi.org/10.1002/jmv.29140" @default.
- W4387392616 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37800627" @default.
- W4387392616 hasPublicationYear "2023" @default.
- W4387392616 type Work @default.
- W4387392616 citedByCount "0" @default.
- W4387392616 crossrefType "journal-article" @default.
- W4387392616 hasAuthorship W4387392616A5009590736 @default.
- W4387392616 hasAuthorship W4387392616A5014367830 @default.
- W4387392616 hasAuthorship W4387392616A5015134471 @default.
- W4387392616 hasAuthorship W4387392616A5040720706 @default.
- W4387392616 hasAuthorship W4387392616A5044874432 @default.
- W4387392616 hasAuthorship W4387392616A5047011282 @default.
- W4387392616 hasAuthorship W4387392616A5047918553 @default.
- W4387392616 hasAuthorship W4387392616A5058506679 @default.
- W4387392616 hasAuthorship W4387392616A5069502084 @default.
- W4387392616 hasAuthorship W4387392616A5082483043 @default.
- W4387392616 hasAuthorship W4387392616A5090133014 @default.
- W4387392616 hasBestOaLocation W43873926161 @default.
- W4387392616 hasConcept C104317684 @default.
- W4387392616 hasConcept C105580179 @default.
- W4387392616 hasConcept C147483822 @default.
- W4387392616 hasConcept C159047783 @default.
- W4387392616 hasConcept C159654299 @default.
- W4387392616 hasConcept C203014093 @default.
- W4387392616 hasConcept C2522874641 @default.
- W4387392616 hasConcept C2779261636 @default.
- W4387392616 hasConcept C2781356689 @default.
- W4387392616 hasConcept C40767141 @default.
- W4387392616 hasConcept C55493867 @default.
- W4387392616 hasConcept C86803240 @default.
- W4387392616 hasConcept C8891405 @default.
- W4387392616 hasConceptScore W4387392616C104317684 @default.
- W4387392616 hasConceptScore W4387392616C105580179 @default.
- W4387392616 hasConceptScore W4387392616C147483822 @default.
- W4387392616 hasConceptScore W4387392616C159047783 @default.
- W4387392616 hasConceptScore W4387392616C159654299 @default.
- W4387392616 hasConceptScore W4387392616C203014093 @default.
- W4387392616 hasConceptScore W4387392616C2522874641 @default.
- W4387392616 hasConceptScore W4387392616C2779261636 @default.
- W4387392616 hasConceptScore W4387392616C2781356689 @default.
- W4387392616 hasConceptScore W4387392616C40767141 @default.
- W4387392616 hasConceptScore W4387392616C55493867 @default.
- W4387392616 hasConceptScore W4387392616C86803240 @default.
- W4387392616 hasConceptScore W4387392616C8891405 @default.
- W4387392616 hasIssue "10" @default.
- W4387392616 hasLocation W43873926161 @default.
- W4387392616 hasLocation W43873926162 @default.
- W4387392616 hasOpenAccess W4387392616 @default.
- W4387392616 hasPrimaryLocation W43873926161 @default.
- W4387392616 hasRelatedWork W1583154990 @default.