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- W4387392712 abstract "Actin-related proteins (Arp) are classified according to their similarity to actin and are involved in diverse cellular processes. ACTL7B is a testis-specific Arp and highly conserved in rodents and primates. ACTL7B is specifically expressed in round and elongating spermatids during spermiogenesis. Here, we have generated an Actl7b-null allele in mice to unravel the role of ACTL7B in sperm formation. Male mice homozygous for the Actl7b-null allele (Actl7b-/-) were infertile, while heterozygous males (Actl7b+/-) were fertile. Severe spermatid defects such as detached acrosomes, disrupted membranes and flagella malformations start to appear after spermiogenesis step 9 in Actl7b-/- mice, finally resulting in spermatogenic arrest. Abnormal spermatids were degraded and autophagy markers were increased. Co-immunoprecipitation with MassSpec experiments identified interaction between ACTL7B and the LC8 dynein light chains DYNLL1 and DYNLL2, which are first detected in step 9 spermatids and mislocalized when ACTL7B is absent. Our data unequivocally establishes that mutations in ACTL7B are directly related to male infertility, pressing for additional research in men." @default.
- W4387392712 created "2023-10-07" @default.
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- W4387392712 date "2023-10-06" @default.
- W4387392712 modified "2023-10-07" @default.
- W4387392712 title "<i>Actl7b-</i>deficiency leads to mislocalization of LC8 type dynein light chains and disruption of murine spermatogenesis" @default.
- W4387392712 doi "https://doi.org/10.1242/dev.201593" @default.
- W4387392712 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37800308" @default.
- W4387392712 hasPublicationYear "2023" @default.
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