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• W4387392816 abstract "Type 1 interferons (IFNs) play a crucial role in the pathogenesis of systemic lupus erythematosus (SLE) and various type I IFNs targeting therapeutic approaches have been developed. Anifrolumab, a monoclonal antibody that binds to the subunit 1 of the type I IFN receptor, has acquired considerable interest and has entered different clinical human trials willing to evaluate its efficacy and safety.This review summarizes the data obtained in phases 1, 2, and 3 clinical trials of anifrolumab for SLE patients. A focus is made on data of clinical efficacy and safety obtained in MUSE, TULIP-1 and TULIP-2 trials.Anifrolumab is a promising therapeutic option for patients with SLE, currently authorized for moderate-to-severe SLE. Extensive real-world use is now going to generate data required to gain experience on the type of patients who benefit the most from the drug, and the exact positioning of anifrolumab in the therapeutic plan." @default.
• W4387392816 created "2023-10-07" @default.
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• W4387392816 date "2023-10-06" @default.
• W4387392816 modified "2023-10-18" @default.
• W4387392816 title "Anifrolumab: first biologic approved in the EU not restricted to patients with a high degree of disease activity for the treatment of moderate to severe systemic lupus erythematosus" @default.
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• W4387392816 doi "https://doi.org/10.1080/1744666x.2023.2268284" @default.
• W4387392816 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37800604" @default.
• W4387392816 hasPublicationYear "2023" @default.
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