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• W4387393337 abstract "Onychomycosis, a multifactorial fungal infection of the nails, shows a global prevalence of about 5.5% and is responsible for 50% of all nail infections. To develop effective management strategies, it is necessary to understand the etiology, pathophysiology, and risk factors of onychomycosis. Oral route of drug delivery is one of the routes utilized to deliver anti-fungal agents, but, has its own limitations like longer duration of treatment, increased adverse effects, and potential for drug interaction. The ungual route has received greater attention due to its localized, non- invasive action and improved patient compliance.This review comprehensively discusses conventional onychomycosis therapies and patented novel drug delivery systems for the management of onychomycosis including chemical permeation enhancers, non-particulate drug delivery systems, penetration enhancing devices etc., Databases such as PubMed, ResearchGate, and Google Patents were searched by using the keywords onychomycosis and trans-ungual drug delivery.Enormous research has been conducted and is still ongoing to find the best possible novel drug delivery system for onychomycosis management. Approaches like incorporation of herbal constituents in nano-formulations, inkjet printing, laser devices, iontophoretic techniques, etc. can be employed to make safe and effective drug delivery systems which are regulatory compliant." @default.
• W4387393337 created "2023-10-07" @default.
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• W4387393337 date "2023-10-06" @default.
• W4387393337 modified "2023-10-15" @default.
• W4387393337 title "THERAPEUTIC TREATMENT STRATEGIES for the MANAGEMENT of ONYCHOMYCOSIS: a PATENT PERSPECTIVE" @default.
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• W4387393337 doi "https://doi.org/10.1080/13543776.2023.2268278" @default.
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• W4387393337 hasPublicationYear "2023" @default.
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