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- W4387393406 abstract "Nonspecific phospholipase C (NPC) plays a pivotal role in hydrolyzing phospholipids, releasing diacylglycerol─an essential second messenger. Extensive research has elucidated the structure and function of bacterial and plant NPCs, but our understanding of their fungal counterparts remains limited. Here, we present the first crystal structure of a fungal NPC derived from Rasamsonia emersonii (RePLC), unraveling its distinguishable features divergent from other known phospholipase C. Remarkably, the structure of RePLC contains solely the phosphoesterase domain without the crucial C-terminal domain (CTD) found in plant NPCs, although CTD is important for their activity. Through a comparative analysis of structural features among NPCs from diverse species combined with structure-based mutation analyses and bioinformatics methods, we propose a potential molecular mechanism that may universally underlie the catalysis of phospholipid hydrolysis in fungal NPCs. Furthermore, our study sheds light on the captivating evolutionary trajectory of enzymes across diverse species." @default.
- W4387393406 created "2023-10-07" @default.
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- W4387393406 date "2023-10-06" @default.
- W4387393406 modified "2023-10-07" @default.
- W4387393406 title "Crystal Structure of Fungal Nonspecific Phospholipase C Unveils a Distinct Catalytic Mechanism" @default.
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- W4387393406 doi "https://doi.org/10.1021/acs.jafc.3c05155" @default.
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