FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387393602> ?p ?o ?g. }

• W4387393602 endingPage "783" @default.
• W4387393602 startingPage "779" @default.
• W4387393602 abstract "Objective: A contrary relationship between body mass index (BMI) and growth hormone (GH) secretion has been demonstrated in adults. BMI-specific cutoff levels are suggested for identifying growth hormone deficiency (GHD) in adulthood. However, specific values for BMI and growth hormone stimulation test responses in the childhood age group are not certain. In this research, our purpose was to investigate the relationship between GH peak response and BMI in children who underwent GHST with a pre-diagnosis of GHD. Material and Methods: This was a retrospective study of stimulative GH testing with clonidine and L-dopa performed in 150 children 2–18 year-old with short stature (< -2 SDS) in the Pediatric Endocrinology Unit at Bakırçay University Çiğli Training and Research Hospital from the years of 2018 to 2023. Anthropometric measurements, insulin-like growth factor-1 (IGF-I) and IGFBP- 3 levels, especially peak-stimulated GH, were evaluated. Results: A total of 150 patients [98 boys (65.3%) and 52 girls (34.7%)] were included in the study. The mean age of the individuals during testing was 10.26 ± 3.37 years, mean height standard deviation score (SDS) was -2.64 ± 0.89, mean weight SDS was -1.85 ± 1.01 and mean body mass index (BMI) SDS was -0.47 ± 1.07. Ninety-two of the patients (63%) were prepubertal. The mean value for maximum growth hormone serum level (GHmax) clonidine collected during the growth hormone stimulation test was 4.46 ± 2.83 ng/mL, while the mean value in L-dopa test was 3.29 ± 2.57 ng/mL. There was no statistical distinction in terms of both test responses. The correlation between peak GH and BMI-SDS, in terms of clonidine and L-dopa tests, was significantly negative [β = -0.257 (p = 0.010), β = -0.283 (p = 0.004), respectively]. Age, gender and puberty were not significantly associated with peak GH value. In terms of L-dopa peak GH level, the GH level in group 4 (>1 SDS) was revealed to be statistically lower than that in group 1 (< -1 SDS), nevertheless, similar relationship was not detected for clonidine. Conclusion: In our study, a negative correlation was found between GHmax and BMI-SDS in terms of clonidine and L-dopa tests. Therefore, keeping BMI-SDS in mind when evaluating growth hormone stimulation tests performed in short children may be guiding. Still, future studies are needed to make it a determining factor when deciding on treatment." @default.
• W4387393602 created "2023-10-07" @default.
• W4387393602 creator A5073998843 @default.
• W4387393602 creator A5084386880 @default.
• W4387393602 date "2023-10-06" @default.
• W4387393602 modified "2023-10-07" @default.
• W4387393602 title "Evaluation of the Relationship Between Peak Growth Hormone Response to Growth Hormone Stimulation Tests and Body Mass Index" @default.
• W4387393602 cites W1512043045 @default.
• W4387393602 cites W2002748611 @default.
• W4387393602 cites W2003077563 @default.
• W4387393602 cites W2060705510 @default.
• W4387393602 cites W2066728700 @default.
• W4387393602 cites W2113316936 @default.
• W4387393602 cites W2143049130 @default.
• W4387393602 cites W2233041445 @default.
• W4387393602 cites W2396402306 @default.
• W4387393602 cites W2409829004 @default.
• W4387393602 cites W2555766993 @default.
• W4387393602 cites W2973019498 @default.
• W4387393602 cites W2987662336 @default.
• W4387393602 cites W4288712579 @default.
• W4387393602 doi "https://doi.org/10.36472/msd.v10i10.1053" @default.
• W4387393602 hasPublicationYear "2023" @default.
• W4387393602 type Work @default.
• W4387393602 citedByCount "0" @default.
• W4387393602 crossrefType "journal-article" @default.
• W4387393602 hasAuthorship W4387393602A5073998843 @default.
• W4387393602 hasAuthorship W4387393602A5084386880 @default.
• W4387393602 hasBestOaLocation W43873936021 @default.
• W4387393602 hasConcept C126322002 @default.
• W4387393602 hasConcept C134018914 @default.
• W4387393602 hasConcept C24998067 @default.
• W4387393602 hasConcept C2777391703 @default.
• W4387393602 hasConcept C2777871287 @default.
• W4387393602 hasConcept C2778399450 @default.
• W4387393602 hasConcept C2779113265 @default.
• W4387393602 hasConcept C2779306644 @default.
• W4387393602 hasConcept C2779952775 @default.
• W4387393602 hasConcept C2780221984 @default.
• W4387393602 hasConcept C2984496839 @default.
• W4387393602 hasConcept C3017594256 @default.
• W4387393602 hasConcept C61427482 @default.
• W4387393602 hasConcept C71315377 @default.
• W4387393602 hasConcept C71924100 @default.
• W4387393602 hasConcept C89551170 @default.
• W4387393602 hasConceptScore W4387393602C126322002 @default.
• W4387393602 hasConceptScore W4387393602C134018914 @default.
• W4387393602 hasConceptScore W4387393602C24998067 @default.
• W4387393602 hasConceptScore W4387393602C2777391703 @default.
• W4387393602 hasConceptScore W4387393602C2777871287 @default.
• W4387393602 hasConceptScore W4387393602C2778399450 @default.
• W4387393602 hasConceptScore W4387393602C2779113265 @default.
• W4387393602 hasConceptScore W4387393602C2779306644 @default.
• W4387393602 hasConceptScore W4387393602C2779952775 @default.
• W4387393602 hasConceptScore W4387393602C2780221984 @default.
• W4387393602 hasConceptScore W4387393602C2984496839 @default.
• W4387393602 hasConceptScore W4387393602C3017594256 @default.
• W4387393602 hasConceptScore W4387393602C61427482 @default.
• W4387393602 hasConceptScore W4387393602C71315377 @default.
• W4387393602 hasConceptScore W4387393602C71924100 @default.
• W4387393602 hasConceptScore W4387393602C89551170 @default.
• W4387393602 hasIssue "10" @default.
• W4387393602 hasLocation W43873936021 @default.
• W4387393602 hasOpenAccess W4387393602 @default.
• W4387393602 hasPrimaryLocation W43873936021 @default.
• W4387393602 hasRelatedWork W1988747060 @default.
• W4387393602 hasRelatedWork W1998681038 @default.
• W4387393602 hasRelatedWork W2331572451 @default.
• W4387393602 hasRelatedWork W2426590255 @default.
• W4387393602 hasRelatedWork W2766969746 @default.
• W4387393602 hasRelatedWork W3029300852 @default.
• W4387393602 hasRelatedWork W4284975223 @default.
• W4387393602 hasRelatedWork W4315783651 @default.
• W4387393602 hasRelatedWork W4377140995 @default.
• W4387393602 hasRelatedWork W2291630034 @default.
• W4387393602 hasVolume "10" @default.
• W4387393602 isParatext "false" @default.
• W4387393602 isRetracted "false" @default.
• W4387393602 workType "article" @default.