FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387394498> ?p ?o ?g. }

• W4387394498 endingPage "105324" @default.
• W4387394498 startingPage "105324" @default.
• W4387394498 abstract "Wolf-Hirschhorn syndrome (WHS) is a developmental disorder attributed to a partial deletion on the short arm of chromosome 4. WHS patients suffer from oral manifestations including cleft lip and palate (CLP), hypodontia, and taurodontism. Wolf-Hirschhorn syndrome candidate 1 gene (WHSC1) is a H3K36-specific methyltransferase that is deleted in every reported case of WHS. Mutation in this gene also results in tooth anomalies in patients. However, the correlation between genetic abnormalities and the tooth anomalies has remained controversial. In our study, we aimed to clarify the role of WHSC1 in tooth development. We profiled the Whsc1 expression pattern during mouse incisor and molar development by immunofluorescence staining and found Whsc1 expression is reduced as tooth development proceeds. Using RT-qPCR, Western blot, ChIP and luciferase assays, we determined that Whsc1 and Pitx2, the initial transcription factor involved in tooth development, positively and reciprocally regulate each other through their gene promoters. MicroRNAs are known to regulate gene expression post-transcriptionally during development. We previously reported miR-23a/b and miR-24-1/2 were highly expressed in the mature tooth germ. Interestingly, we demonstrate here that these two miRs directly target Whsc1 and repress its expression. Additionally, this miR cluster is also negatively regulated by Pitx2. We show the expression of these two miRs and Whsc1 are inversely correlated during mouse mandibular development. Taken together, our results provide new insights into the potential role of Whsc1 in regulating tooth development and a possible molecular mechanism underlying the dental defects in WHS." @default.
• W4387394498 created "2023-10-07" @default.
• W4387394498 creator A5039755136 @default.
• W4387394498 creator A5040849390 @default.
• W4387394498 creator A5046830962 @default.
• W4387394498 creator A5057361751 @default.
• W4387394498 creator A5077854868 @default.
• W4387394498 date "2023-10-01" @default.
• W4387394498 modified "2023-10-14" @default.
• W4387394498 title "Wolf-Hirschhorn Syndrome Candidate 1 (Whsc1) Methyltransferase Signals Via a Pitx2-miR-23/24 Axis to Effect Tooth Development" @default.
• W4387394498 cites W144423133 @default.
• W4387394498 cites W147487355 @default.
• W4387394498 cites W1556178984 @default.
• W4387394498 cites W1582943038 @default.
• W4387394498 cites W1662926935 @default.
• W4387394498 cites W1674167019 @default.
• W4387394498 cites W1957085079 @default.
• W4387394498 cites W1972252771 @default.
• W4387394498 cites W1972959575 @default.
• W4387394498 cites W1974110256 @default.
• W4387394498 cites W1975235259 @default.
• W4387394498 cites W1980062177 @default.
• W4387394498 cites W1980197759 @default.
• W4387394498 cites W1987855481 @default.
• W4387394498 cites W1989619365 @default.
• W4387394498 cites W1991382572 @default.
• W4387394498 cites W1993391636 @default.
• W4387394498 cites W2008362502 @default.
• W4387394498 cites W2026356171 @default.
• W4387394498 cites W2027150844 @default.
• W4387394498 cites W2037115398 @default.
• W4387394498 cites W2039191702 @default.
• W4387394498 cites W2039550064 @default.
• W4387394498 cites W2046696024 @default.
• W4387394498 cites W2047286107 @default.
• W4387394498 cites W2048350099 @default.
• W4387394498 cites W2048581231 @default.
• W4387394498 cites W2051842310 @default.
• W4387394498 cites W2051972832 @default.
• W4387394498 cites W2058762628 @default.
• W4387394498 cites W2061135487 @default.
• W4387394498 cites W2062839277 @default.
• W4387394498 cites W2064382418 @default.
• W4387394498 cites W2065498897 @default.
• W4387394498 cites W2069510441 @default.
• W4387394498 cites W2070659209 @default.
• W4387394498 cites W2073567151 @default.
• W4387394498 cites W2074873270 @default.
• W4387394498 cites W2079372953 @default.
• W4387394498 cites W2082493066 @default.
• W4387394498 cites W2092382470 @default.
• W4387394498 cites W2099221458 @default.
• W4387394498 cites W2103266668 @default.
• W4387394498 cites W2104772248 @default.
• W4387394498 cites W2113322776 @default.
• W4387394498 cites W2118523025 @default.
• W4387394498 cites W2127081697 @default.
• W4387394498 cites W2129620440 @default.
• W4387394498 cites W2133834926 @default.
• W4387394498 cites W2138181458 @default.
• W4387394498 cites W2141712044 @default.
• W4387394498 cites W2144320655 @default.
• W4387394498 cites W2161778191 @default.
• W4387394498 cites W2166986764 @default.
• W4387394498 cites W2168327939 @default.
• W4387394498 cites W2171260596 @default.
• W4387394498 cites W2292416504 @default.
• W4387394498 cites W2485197754 @default.
• W4387394498 cites W2521838400 @default.
• W4387394498 cites W2606397279 @default.
• W4387394498 cites W2612730407 @default.
• W4387394498 cites W2804042850 @default.
• W4387394498 cites W2889245200 @default.
• W4387394498 cites W2893841223 @default.
• W4387394498 cites W2896753861 @default.
• W4387394498 cites W2898685101 @default.
• W4387394498 cites W2945269534 @default.
• W4387394498 cites W2948368615 @default.
• W4387394498 cites W2966574966 @default.
• W4387394498 cites W3042502275 @default.
• W4387394498 cites W3043103177 @default.
• W4387394498 cites W3097423319 @default.
• W4387394498 cites W3155784128 @default.
• W4387394498 cites W4286511750 @default.
• W4387394498 cites W4312005973 @default.
• W4387394498 doi "https://doi.org/10.1016/j.jbc.2023.105324" @default.
• W4387394498 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37806494" @default.
• W4387394498 hasPublicationYear "2023" @default.
• W4387394498 type Work @default.
• W4387394498 citedByCount "0" @default.
• W4387394498 crossrefType "journal-article" @default.
• W4387394498 hasAuthorship W4387394498A5039755136 @default.
• W4387394498 hasAuthorship W4387394498A5040849390 @default.
• W4387394498 hasAuthorship W4387394498A5046830962 @default.
• W4387394498 hasAuthorship W4387394498A5057361751 @default.
• W4387394498 hasAuthorship W4387394498A5077854868 @default.
• W4387394498 hasBestOaLocation W43873944981 @default.
• W4387394498 hasConcept C101762097 @default.

• next