Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387394502> ?p ?o ?g. }
Showing items 1 to 61 of
61
with 100 items per page.
- W4387394502 abstract "The liver has numerous functions, including nutrient metabolism. In contrast to other in vitro and in vivo models of liver research, the isolated perfused liver allows the study of liver biology and metabolism in the whole liver with an intact hepatic architecture, separated from the influence of extra-hepatic factors. Liver perfusions were originally developed for rats, but the method has been adapted to mice as well. Here we describe a protocol for in situ perfusion of the mouse liver. The liver is perfused antegradely through the portal vein with oxygenated Krebs-Henseleit bicarbonate buffer, and the output is collected from the suprahepatic inferior vena cava with clamping of the infrahepatic inferior vena cava to close the circuit. Using this method, the direct hepatic effects of a test compound can be evaluated with a detailed time resolution. Liver function and viability are stable for at least 3 h, allowing the inclusion of internal controls in the same experiment. The experimental possibilities using this model are numerous and may infer insight into liver physiology and liver diseases." @default.
- W4387394502 created "2023-10-07" @default.
- W4387394502 creator A5000231124 @default.
- W4387394502 creator A5030437138 @default.
- W4387394502 creator A5065850266 @default.
- W4387394502 creator A5074129762 @default.
- W4387394502 creator A5075454182 @default.
- W4387394502 date "2023-10-06" @default.
- W4387394502 modified "2023-10-07" @default.
- W4387394502 title "Hepatic Glucose Production, Ureagenesis, and Lipolysis Quantified using the Perfused Mouse Liver Model" @default.
- W4387394502 doi "https://doi.org/10.3791/65596" @default.
- W4387394502 hasPublicationYear "2023" @default.
- W4387394502 type Work @default.
- W4387394502 citedByCount "0" @default.
- W4387394502 crossrefType "journal-article" @default.
- W4387394502 hasAuthorship W4387394502A5000231124 @default.
- W4387394502 hasAuthorship W4387394502A5030437138 @default.
- W4387394502 hasAuthorship W4387394502A5065850266 @default.
- W4387394502 hasAuthorship W4387394502A5074129762 @default.
- W4387394502 hasAuthorship W4387394502A5075454182 @default.
- W4387394502 hasConcept C126322002 @default.
- W4387394502 hasConcept C134018914 @default.
- W4387394502 hasConcept C146957229 @default.
- W4387394502 hasConcept C150903083 @default.
- W4387394502 hasConcept C207001950 @default.
- W4387394502 hasConcept C2779033008 @default.
- W4387394502 hasConcept C2910216633 @default.
- W4387394502 hasConcept C2992208098 @default.
- W4387394502 hasConcept C512861765 @default.
- W4387394502 hasConcept C62231903 @default.
- W4387394502 hasConcept C71924100 @default.
- W4387394502 hasConcept C86803240 @default.
- W4387394502 hasConceptScore W4387394502C126322002 @default.
- W4387394502 hasConceptScore W4387394502C134018914 @default.
- W4387394502 hasConceptScore W4387394502C146957229 @default.
- W4387394502 hasConceptScore W4387394502C150903083 @default.
- W4387394502 hasConceptScore W4387394502C207001950 @default.
- W4387394502 hasConceptScore W4387394502C2779033008 @default.
- W4387394502 hasConceptScore W4387394502C2910216633 @default.
- W4387394502 hasConceptScore W4387394502C2992208098 @default.
- W4387394502 hasConceptScore W4387394502C512861765 @default.
- W4387394502 hasConceptScore W4387394502C62231903 @default.
- W4387394502 hasConceptScore W4387394502C71924100 @default.
- W4387394502 hasConceptScore W4387394502C86803240 @default.
- W4387394502 hasIssue "200" @default.
- W4387394502 hasLocation W43873945021 @default.
- W4387394502 hasOpenAccess W4387394502 @default.
- W4387394502 hasPrimaryLocation W43873945021 @default.
- W4387394502 hasRelatedWork W2052969202 @default.
- W4387394502 hasRelatedWork W2114052001 @default.
- W4387394502 hasRelatedWork W2353778634 @default.
- W4387394502 hasRelatedWork W2359744743 @default.
- W4387394502 hasRelatedWork W2399067416 @default.
- W4387394502 hasRelatedWork W2468479442 @default.
- W4387394502 hasRelatedWork W2907883410 @default.
- W4387394502 hasRelatedWork W4225933243 @default.
- W4387394502 hasRelatedWork W4294219357 @default.
- W4387394502 hasRelatedWork W4322754104 @default.
- W4387394502 isParatext "false" @default.
- W4387394502 isRetracted "false" @default.
- W4387394502 workType "article" @default.