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• W4387395526 abstract "Abstract Despite presenting a worse prognosis and being associated with highly aggressive tumors, triple-negative breast cancer (TNBC) is characterized by the higher frequency of tumor-infiltrating lymphocytes, which have been implicated in better overall survival and response to therapy. Although in the last decades, the role and dynamics of tumor-infiltrating T cells have been extensively characterized, much less is known for B cells. Though recent studies have reported the capacity of B lymphocytes to recognize overly-expressed normal proteins, and tumor-associated antigens, how tumor development potentially modifies B cell response is yet to be elucidated. Our findings reveal distinct effects of 4T1 and E0771 murine tumor development on B cells in secondary lymphoid organs. Notably, we observe a significant expansion of total B cells and plasma cells in the tumor-draining lymph nodes (tDLNs) as early as 7 days after tumor challenge in both murine models, whereas changes in the spleen are less pronounced. Surprisingly, within the tumor microenvironment (TME) of both models, we detect distinct B cell subpopulations, but tumor development does not appear to cause major alterations in their frequency over time. Furthermore, our investigation into B cell regulatory phenotypes highlights that the B10 Breg phenotype remains unaffected in the evaluated tissues. However, we identified an increase in CD19 + LAG-3 + cells in tDLNs of both murine models. Interestingly, although CD19 + LAG-3 + cells represent a minor subset of total B cells (< 3%) in all evaluated tissues, most of these cells exhibit elevated expression of IgD, suggesting that LAG-3 may serve as an activation marker for B cells. In summary, our study demonstrates that TNBCs have a significant impact on the dynamics of B cells in secondary lymphoid organs, particularly in tDLNs. These findings suggest that TNBCs may influence the generation of antibodies and the immune response against tumor cells, shedding light on a relatively unexplored aspect of the immune microenvironment in TNBC." @default.
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• W4387395526 date "2023-10-06" @default.
• W4387395526 modified "2023-10-18" @default.
• W4387395526 title "Impact of murine breast tumor development in the kinetics of B cell subpopulations" @default.
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• W4387395526 doi "https://doi.org/10.21203/rs.3.rs-3389534/v1" @default.
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