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- W4387395676 abstract "Abstract Invasive candidiasis (IC) is a fungal infection caused by yeasts of the Candida genus, being Candida albicans the most frequently isolated species. These infections are associated with high mortality rates due to challenges in diagnosis, and pose a significant problem, especially for critically ill patients and those with immunosuppression or undergoing transplantation. To evaluate the activity of antibodies produced by patients with IC, particularly focusing on CAGTA that recognize specific antigens located on the cell wall surface of C. albicans germ tubes. We used sera from 29 patients with IC caused by either C. albicans or non-albicans Candida species. Whole serum IgG antibodies were divided into various fractions: anti-blastospores, CAGTA-enriched and purified CAGTA. The effect of these antibodies on C. albicans was assessed by XTT colorimetric assay to evaluate metabolic activity, CFU counts for viability assessment, and microscopy for growth, viability and morphological analysis. Compared with the anti-blastospores, the CAGTA-enriched IgG fraction was mainly responsible for reducing the metabolic activity and viability of C. albicans cells. Purified CAGTA (20 µg/ml) altered the cell wall surface of germ tubes, and DiBAC fluorescent staining revealed that they were fungicidal. In conclusion, antibodies produced in response to invasive candidiasis have antifungal activity against Candida albicans. Purified CAGTA altered the cell wall structure and induced cell death. These findings suggest the potential use of CAGTA and related antigens as diagnostic markers and the development of immunization protocols for protection against Candida infections." @default.
- W4387395676 created "2023-10-07" @default.
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- W4387395676 date "2023-10-06" @default.
- W4387395676 modified "2023-10-07" @default.
- W4387395676 title "Antifungal Activity of Human Antibodies against Candida albicans germ tubes (CAGTA) in Invasive Candidiasis: Implications for Diagnosis and Immunization" @default.
- W4387395676 doi "https://doi.org/10.21203/rs.3.rs-3378546/v1" @default.
- W4387395676 hasPublicationYear "2023" @default.
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