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• W4387396054 abstract "To understand the familial aggregation of mortality in relatives of men undergoing fertility assessment. We identified a retrospective cohort from the Subfertility, Health and Assisted Reproduction (SHARE) study (compiled 1996-2017) linked with familial information from the Utah Population Database (UPDB). Men with a recorded semen analysis (SA) and adequate familial and follow-up data (N=12,231) were included in the analysis and matched with a sample of age- and sex-matched fertile controls from the Utah population (N=86,679) who were also linked with familial information. Men with SAs were classified by average sperm concentration as azoospermic (0 M/ml), oligozoospermic, (<15M/ml), normozoospermic (15-178M/ml) or hyperzoospermic (≥178M/ml). The main outcomes were mortality risk by age and degree of relation: first- (FDR), second- (SDR), and third-degree (TDR). All-cause Cox proportional hazard models were used to test he association between fertility classification and familial mortality controlling for sex. A total of 775,760 relatives of men with SA (Ndeaths=281,744 ) and 5,587,383 relatives of controls (Ndeaths=2,004,029) were included in the analysis. Relative to control families, observed risk of all-cause mortality increased in azoospermic families and decreased in normozoospermic and hyperzoospermic families during this period of follow-up (HRazoo=1.06 95%CI=1.04-1.08; HRnormo=0.96 95%CI=0.95-0.96; HRhyper= 0.97 95%CI=0.96-0.98). No difference was observed in mortality risk for oligozoospermic families. Relatives of azoospermic men showed increased risk for all-cause mortality in all age categories except 60-64 years, with the highest increases seen at younger ages (HR0-9=1.45 95%CI=1.33-1.59; HR10-19=1.34 95%CI=1.17-1.54; HR20-29=1.17 95%CI=1.03-1.32). We found no significant differences in mortality risk for FDR of azoospermic and oligozoospermic men, however, SDR and TDR of azoospermic men showed increased risk (HRSDR=1.10 95%CI=1.05-1.15; HRTDR=1.06 95%CI=1.04-1.09). All degrees of relation for normozoospermic and hyperzoospermic men showed significantly decreased all-cause mortality risk during this period of follow-up. Our results suggest that familial all-cause mortality risk differs by fertility phenotype. Families of azoospermic men showed significantly increased risk for all-cause mortality, particularly for childhood and adolescent mortality. This study provides further evidence that shared genetic and/or environmental factors could influence both semen quality and mortality risk." @default.
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• W4387396054 date "2023-10-01" @default.
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• W4387396054 title "RISK OF MORTALITY IN FAMILY MEMBERS OF MEN SEEKING FERTILITY ASSESSMENT" @default.
• W4387396054 doi "https://doi.org/10.1016/j.fertnstert.2023.08.846" @default.
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