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- W4387396114 abstract "To study if dienogest improve the controlled ovarian stimulation (COS) outcomes of endometriosis patients with no history of previous surgery or other medications. The medical records of endometriosis patients from January 2018 to December 2022 in a single tertiary center were retrospectively reviewed.Patients who were diagnosed with endometriosis using ultrasound and did not undergo ovarian cystectomy were included. They were recommended COS for pregnancy or fertility preservation and underwent total 55 cycles. Dienogest pretreatment for 3 months was performed in 14 COS cycles and 41 COS cycles were classified as the control. Age, AMH, antral follicle count (AFC), body mass index (BMI), starting and total gonadotropin dose, stimulation days, the number of follicles more than 14mm, retrieved oocytes, mature oocytes, and degenerated oocytes were compared between the two groups. Continuous variables were analyzed using student t-test and Mann-Whitney U test. Clinical characteristics, such as age (33.9±5.54 vs. 35.27±5.10, p>0.05), AMH (0.76 [0.12-4.97] vs. 1.74 [0.02-10.48], p>0.05), AFC (3 [0-20] vs. 8 [0-16], p>0.05) and BMI (21.9±3.09 vs. 21.3±1.53, p>0.05) were statistically similar between the dienogest group and control. The number of follicles larger than 14mm was not different between the two groups (3 [1-8] vs. 4 [1-14], p>0.05). The dienogest group received lower total dose of gonadotropins (1883.0±1398.8 vs. 2771.3±1208.4, p=0.027) for shorter duration (6.50±2.65 vs. 8.12±2.25, p=0.030). Neither the number of retrieved oocytes (4.5 vs. 7.0, p>0.05) nor mature oocytes (2.5 vs. 4.0, p>0.05) was significantly different between the dienogest group and control. Number of degenerated oocytes (0[0-3] vs. 0[0-6], p=0.042) was statistically significant between the two groups. Patients with endometriosis who had been previous treated with dienogest received lower dose of gonadotropin for a shorter duration with similar COS outcomes." @default.
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- W4387396114 date "2023-10-01" @default.
- W4387396114 modified "2023-10-07" @default.
- W4387396114 title "THE EFFECT OF DIENOGEST PRETREATMENT ON CONTROLLED OVARIAN STIMULATION IN ENDOMETRIOSIS PATIENTS" @default.
- W4387396114 doi "https://doi.org/10.1016/j.fertnstert.2023.08.802" @default.
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