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- W4387396316 abstract "To assess transcriptional profiles of phenotypically distinct endometriosis lesions. Patients presenting for endometriosis care were administered baseline health-related quality of life questionnaires to evaluate pre-and post-treatment pain scores and followed longitudinally following informed consent with IRB approval. Surgically discarded tissue from 20 of these participants and 5- controls were collected from three different locations: eutopic endometrium, peritoneal membrane, and ectopic lesions. Ectopic lesions were phenotypically stratified into clear and red lesions. Tissue was then processed for RNA extraction, immunohistochemistry, and western blot analysis. Whole-transcriptome bulk sequencing of superficial lesions and differential gene expression analysis (DGE) was then performed. Differential gene expression comparisons of red and clear lesions demonstrate increased lymphocyte activity, cytokine production, and inflammatory hallmark signatures in red lesions. Network analysis of somatic variants and differentially expressed genes reveals the interaction of the endometriosis-related oncogenes PIK3CA/EGFR with the cancer-related Notch1 pathway driver gene, EP300. These findings were then functionally validated via IHC and Western Blotting. In summary, somatic mutations in cancer driver genes were found in high proportion in superficial red peritoneal lesions relative to clear lesions. We show that chromatin accessibility, the RAS pathway (Rat Sarcoma), and differentiation-related genes are mutated in red lesions." @default.
- W4387396316 created "2023-10-07" @default.
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- W4387396316 date "2023-10-01" @default.
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- W4387396316 title "DIFFERENTIAL TRANSCRIPTIONAL PROFILES IN PHENOTYPICALLY DISTINCT ENDOMETRIOSIS LESIONS SHOW INCREASED LYMPHOCYTE ACTIVITY, CYTOKINE PRODUCTION, AND INFLAMMATORY MARKERS IN RED LESIONS" @default.
- W4387396316 doi "https://doi.org/10.1016/j.fertnstert.2023.08.652" @default.
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