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- W4387396511 abstract "It has been suggested that macrophages have key role in assembling the immune tolerance during the process of embryo implantation. In the mid-secretory endometrium, however, different sets of macrophages are present depending on their inflammatory action. The aim was to compare the main macrophages populations’ quantity and spatial distribution in the mid-secretory endometrium between women with successful and failed embryo implantation. Endometrial tissue from 20 patients with successful and 20 with failed embryo implantation, without inflammation and endometrial pathologies were selected from the hospitals tissue bank. All samples were obtained by regular diagnostic biopsy during mid-luteal phase of the menstrual cycle (LH+7) from unstimulated IVF patients 1-month prior embryo transfer. All samples were immunohistochemically stained against 3 sets of macrophages: pan-macrophages (CD68+, IS61330-2, Dako), anti-inflammatory macrophages (CD163+, 2-CD353-13, Quartett) and pro-inflammatory macrophages (CD11c+, 60258-1, Proteintech), using novolink polymer detection system (RE7280-K, Leica) according to the manufacturer’s instructions. The studied immune cells quantity and density were analysed by HALO image analysis software (Indica Labs) using the CytoNuclear and Spatial Analysis modules. Number of cells per mm2 and max number of cells per μm2 in 50μm radius in both groups were compared by Mann-Whitney U test. Median number (range) of macrophages in the successful and the failed embryo implantation groups are: 277/mm2 (402) and 211/mm2 (297), respectively CD68+ cells; 93/mm2 (188) and 100/mm2 (127), respectively CD163+ cells with no significant differences between the two groups (p>0.05). Significantly higher number of CD11c+ cells, however, were observed in the successful embryo implantation group when compared to the failed one – 58/mm2 (114) and 21/mm2 (56), respectively, p<0.013. In terms of spatial distribution, the density of pro- and anti-inflammatory macrophages in 50 μm radius of each cell in both successful and failed embryo implantation groups were not significantly different: 3.6x103/μm2 (3.3) and 3.3x103/μm2 (3.2) for CD11c+ cells (p=0.57); 2.7x103/μm2 (4.3) and 2.3x103/μm2 (3.6) for CD163+ cells (p=0.33). While the density of CD68+ macrophages was significantly higher in the successful embryo implantation patients when compared to the failed ones: 2.2x103/μm2 (2.9) and 1.4x103/μm2 (1.7), respectively, p=0.015. Higher number of anti-inflammatory macrophages indicated for successful embryo implantation. Clusters of pro- and anti-inflammatory macrophages were not related to embryo implantation outcome, in contrast to pan-macrophages density, which was higher in the successful embryo implantation cases." @default.
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- W4387396511 date "2023-10-01" @default.
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- W4387396511 title "ENDOMETRIAL MACROPHAGES AND EMBRYO IMPLANTATION" @default.
- W4387396511 doi "https://doi.org/10.1016/j.fertnstert.2023.08.429" @default.
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