FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387396578> ?p ?o ?g. }

• W4387396578 endingPage "e29" @default.
• W4387396578 startingPage "e29" @default.
• W4387396578 abstract "Infertility is a widespread issue in industrialized countries whose etiology is still elusive in a significant percentage of cases. Epigenetics, consisting of molecular changes (including methylation) that modulate gene expression, can be a possible cause of male infertility and represent an aid in the diagnostic process. The mesoderm-specific transcription (MEST) gene is a paternally expressed imprinted gene that, among others, appears to play a role in embryo survival. Data are available on the methylation pattern of the MEST gene in spermatozoa of infertile patients. The latest meta-analysis on this topic was published in 2017 and showed that the methylation pattern of this gene is significantly higher in spermatozoa from infertile or oligozoospermic patients than in fertile or normozoospermic controls. Therefore, the present study aimed to provide an updated and comprehensive systematic review and meta-analysis of the MEST gene methylation pattern in patients with abnormal sperm parameters compared to men with normal parameters. This meta-analysis was registered in PROSPERO (n. 397056) and performed following the MOOSE guidelines for Meta-analyses and Systematic Reviews of Observational Studies and the Preferred Reporting Items for Systematic Reviews and Meta-Analysis Protocols (PRISMA-P). Only original articles evaluating MEST gene methylation in spermatozoa from patients with infertility or abnormalities in one or more sperm parameters compared to fertile or normozoospermic men were included. Of the 354 abstracts evaluated for eligibility, only 6 studies were included in the quantitative synthesis, involving a total of 301 patients and 163 controls. Our analysis showed significantly higher levels of MEST gene methylation in patients compared with controls (SMD 2.150, 95% CI 0.377, 3.922, p = 0.017), although there was significant heterogeneity between studies (Q-value = 239.90, p-value 0; I2 = 97.91%). No significant evidence of publication bias was found, although one study was sensitive enough to skew the results, leading to a loss of significance (SMD 1.543, 95% CI -0.300, 3.387, p = 0.062). In meta-regression analysis, we found that the results were independent of both age (p= 0.6519) and sperm concentration (p= 0.2360). The results of this systematic review and meta-analysis showed that the methylation pattern of the MEST gene appears to be related to the quality of sperm parameters, without being influenced by age and sperm concentration. Although its role in male infertility remains to be elucidated, sperm DNA methylation may be associated with epigenetic risk in assisted reproductive techniques (ART)." @default.
• W4387396578 created "2023-10-07" @default.
• W4387396578 creator A5010640509 @default.
• W4387396578 creator A5021384634 @default.
• W4387396578 creator A5034605711 @default.
• W4387396578 creator A5045375157 @default.
• W4387396578 creator A5050080012 @default.
• W4387396578 creator A5053379997 @default.
• W4387396578 creator A5066298126 @default.
• W4387396578 creator A5091212489 @default.
• W4387396578 date "2023-10-01" @default.
• W4387396578 modified "2023-10-17" @default.
• W4387396578 title "SPERM MESODERM SPECIFIC TRANSCRIPT GENE METHYLATION STATUS IN INFERTILE PATIENTS: A SYSTEMATIC REVIEW AND META-ANALYSIS" @default.
• W4387396578 doi "https://doi.org/10.1016/j.fertnstert.2023.08.123" @default.
• W4387396578 hasPublicationYear "2023" @default.
• W4387396578 type Work @default.
• W4387396578 citedByCount "0" @default.
• W4387396578 crossrefType "journal-article" @default.
• W4387396578 hasAuthorship W4387396578A5010640509 @default.
• W4387396578 hasAuthorship W4387396578A5021384634 @default.
• W4387396578 hasAuthorship W4387396578A5034605711 @default.
• W4387396578 hasAuthorship W4387396578A5045375157 @default.
• W4387396578 hasAuthorship W4387396578A5050080012 @default.
• W4387396578 hasAuthorship W4387396578A5053379997 @default.
• W4387396578 hasAuthorship W4387396578A5066298126 @default.
• W4387396578 hasAuthorship W4387396578A5091212489 @default.
• W4387396578 hasBestOaLocation W43873965781 @default.
• W4387396578 hasConcept C104317684 @default.
• W4387396578 hasConcept C126322002 @default.
• W4387396578 hasConcept C150194340 @default.
• W4387396578 hasConcept C16685009 @default.
• W4387396578 hasConcept C190727270 @default.
• W4387396578 hasConcept C2777338322 @default.
• W4387396578 hasConcept C2777688143 @default.
• W4387396578 hasConcept C2778580812 @default.
• W4387396578 hasConcept C2779234561 @default.
• W4387396578 hasConcept C2781087480 @default.
• W4387396578 hasConcept C33288867 @default.
• W4387396578 hasConcept C41091548 @default.
• W4387396578 hasConcept C54355233 @default.
• W4387396578 hasConcept C60644358 @default.
• W4387396578 hasConcept C71924100 @default.
• W4387396578 hasConcept C86803240 @default.
• W4387396578 hasConcept C95190672 @default.
• W4387396578 hasConceptScore W4387396578C104317684 @default.
• W4387396578 hasConceptScore W4387396578C126322002 @default.
• W4387396578 hasConceptScore W4387396578C150194340 @default.
• W4387396578 hasConceptScore W4387396578C16685009 @default.
• W4387396578 hasConceptScore W4387396578C190727270 @default.
• W4387396578 hasConceptScore W4387396578C2777338322 @default.
• W4387396578 hasConceptScore W4387396578C2777688143 @default.
• W4387396578 hasConceptScore W4387396578C2778580812 @default.
• W4387396578 hasConceptScore W4387396578C2779234561 @default.
• W4387396578 hasConceptScore W4387396578C2781087480 @default.
• W4387396578 hasConceptScore W4387396578C33288867 @default.
• W4387396578 hasConceptScore W4387396578C41091548 @default.
• W4387396578 hasConceptScore W4387396578C54355233 @default.
• W4387396578 hasConceptScore W4387396578C60644358 @default.
• W4387396578 hasConceptScore W4387396578C71924100 @default.
• W4387396578 hasConceptScore W4387396578C86803240 @default.
• W4387396578 hasConceptScore W4387396578C95190672 @default.
• W4387396578 hasIssue "4" @default.
• W4387396578 hasLocation W43873965781 @default.
• W4387396578 hasOpenAccess W4387396578 @default.
• W4387396578 hasPrimaryLocation W43873965781 @default.
• W4387396578 hasRelatedWork W2052355316 @default.
• W4387396578 hasRelatedWork W2128056428 @default.
• W4387396578 hasRelatedWork W2263009103 @default.
• W4387396578 hasRelatedWork W2403194036 @default.
• W4387396578 hasRelatedWork W2409625967 @default.
• W4387396578 hasRelatedWork W2902329290 @default.
• W4387396578 hasRelatedWork W2938840050 @default.
• W4387396578 hasRelatedWork W3092855052 @default.
• W4387396578 hasRelatedWork W4245184220 @default.
• W4387396578 hasRelatedWork W4380667518 @default.
• W4387396578 hasVolume "120" @default.
• W4387396578 isParatext "false" @default.
• W4387396578 isRetracted "false" @default.
• W4387396578 workType "article" @default.