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- W4387396619 abstract "To examine the impact of oral prednisone therapy on sperm parameters in men with a prior vasovasostomy and declining postoperative semen kinetics. A retrospective chart review was performed at a single institution from 2016-2023 utilizing the CPT code 55400 (bilateral vasovasostomy). Patient charts were queried for declining postoperative semen analysis metrics in conjunction with initiation of prednisone 5 mg for six weeks. Total motile sperm count (TMSC) was examined as the percentage of change following completion of prednisone therapy. Criteria for pharmacologic intervention included patients with greater than 50% decrease in TMSC following baseline postoperative semen analysis. From 2016-2023 a total of 171 patients underwent bilateral vasovasostomy. Of these patients, 9 (5.3%) were identified as having deteriorating semen kinetics. There were a total of 12 instances of deterioration of sperm parameter kinetics among these patients. All 9 patients underwent 6 weeks of low-dose prednisone therapy at a median of 76.2 weeks from vasovasostomy. Overall, 88.9% (n=8) and 75% (n=9) of patients and instances responded to prednisone therapy with reversal of semen kinetics. The median pre-treatment TMSC was 0 (interquartile range: 0-1 million) while the median post-treatment TMSC was 3 million (interquartile range: 3.0-10.0 million) (p < 0.05). No adverse events were reported with prednisone therapy. There remains a paucity of literature examining the pharmacologic rescue of declining sperm parameters following vasovasostomy. Modulating the immune and inflammatory response with low-dose prednisone appears both safe and potentially efficacious in reversing decline in sperm parameters." @default.
- W4387396619 created "2023-10-07" @default.
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- W4387396619 date "2023-10-01" @default.
- W4387396619 modified "2023-10-07" @default.
- W4387396619 title "ORAL PREDNISONE AS A RESCUE INTERVENTION FOR DETERIORATING SPERM PARAMETERS FOLLOWING VASOVASOSTOMY" @default.
- W4387396619 doi "https://doi.org/10.1016/j.fertnstert.2023.08.125" @default.
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