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- W4387396709 abstract "The objective of this study was to assess the incidence of recurrent implantation failure (RIF) following uterus transplantation (UTx) and to review the interventions leading to successful live birth in those with RIF. Data was collected from three UTx centers in the US with institutional review board approval. RIF was defined using the 2022 Lugano Workshop consensus: ≥3 failed euploid transfer or ≥4 untested embryos in patients <35 years old, with biochemical pregnancies included in implantation failures [1]. When comparing groups (RIF versus non-RIF), Wilcoxon rank sum was used for continuous variables and Fischer exact test was used for categorical variables. Of the 25 technically successful transplants who underwent embryo transfer, 6 patients met criteria for RIF (24%). Of these, half utilized deceased donors and half utilized living donors. Four of the 6 patients subsequently went on to have a live birth (67%), with an average of 4 transfers needed before successful pregnancy. The remaining 2 patients are continuing to attempt pregnancy. Of these two, one (16.7%) has a uterus from a nulliparous donor, which was unique in the entire cohort of 25 transplants. There was not a statistically significant difference in the average age at egg retrieval, dose/duration of immunosuppression, cold ischemia time, warm ischemia time, embryo grade, endometrial thickness at time of transfer in patients with RIF versus those without.Of RIF patients with subsequent live birth, 25% underwent operative hysteroscopy, 25% received empiric anticoagulation (lovenox and aspirin), 25% increased steroids, 50% received empiric immune therapies (IVIG or intralipid infusion), and 25% used a natural FET cycle (versus 75% programmed). UTx recipients who experience RIF have a high likelihood of subsequent live birth. The causes and treatment of RIF in this population warrants further study and may provide insights into RIF for the general population." @default.
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- W4387396709 date "2023-10-01" @default.
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- W4387396709 title "INCIDENCE AND MANAGEMENT OF RECURRENT IMPLANTATION FAILURE FOR UTERUS TRANSPLANTATION RECIPIENTS IN THE UNITED STATES" @default.
- W4387396709 doi "https://doi.org/10.1016/j.fertnstert.2023.08.255" @default.
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