FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387396720> ?p ?o ?g. }

• W4387396720 endingPage "e15" @default.
• W4387396720 startingPage "e14" @default.
• W4387396720 abstract "Transgender and gender-diverse adults may utilize testosterone (T) gender-affirming hormone therapy (GAHT) to achieve embodiment goals. Some T-GAHT users choose to become gestational parents but T-GAHT alters the hypothalamic-pituitary-gonadal axis, which is critical to maintaining early pregnancies, along with the reproductive tract. Importantly, gestation requires cessation of T-GAHT as high T is detrimental to offspring sexual development. We examined Ts potential to impact the gestational capacity of mice and offspring reproductive health after ceasing short- or long-term T-GAHT treatment. Adult CD1 female (n=14-15/group) mice were implanted with a capsule containing 10 mg T or left blank (B). Implants were left for 6 or 12 weeks before removal. Following three days of recovery, T-GAHT and control mice were housed with a proven breeder CD1 male. Breeding pairs were allowed to produce two litters before dams were sacrificed and tissue collected. Offspring were weaned and their sexual development tracked before collecting tissue. Tissues from dams and female offspring were collected during diestrus. Students t-tests were used to compare between T and B treated animals of the same treatment duration. T-tests were also used for offspring measurements, which were averaged by dam and separated by dam treatment duration and litter. Short- and long-term T-GAHT increased the time between pairing and first parturition compared with controls (Short B 23.2±1.4, Short T 25.5±4, Long B 22.3±1.3, Long T 24.5±3.1). Long-term treatment decreased pup numbers in first litters (Short B=11.5±2, Short T=11.4±4, Long B=11.9±3, Long T=7.8±3 Pups). Both short- and long-term T-GAHT influenced pubertal onset, measured by vaginal opening and preputial sheath separation, which was earlier for first-litter male and female pups from T-GAHT mice. The detrimental effects of T-GAHT on dam fertility and offspring development disappeared when examining their second gestation and litters. T-GAHT treatment caused permanent changes to dam anatomy, including larger clitoris areas (Short B=6.3) and heavier uterine horns (Short B=115.3±39, Short T=157.1±57, Long B=128.8±33, Long T=162.8±45.1 mg), while the impact of T-GAHT on offspring tissues was minimal and restricted to first litters. Both short- and long-term T-GAHT are detrimental to gestation and disrupt offspring sexual development. However, these effects are not permanent, and the subfertility seen during the first gestational period is lost in the second. Concurrently, offspring measures from second litters are not significantly impacted by dam T-GAHT treatment. Dams previously given T-GAHT retain anatomical changes to their reproductive system, which do not appear to impact fertility." @default.
• W4387396720 created "2023-10-07" @default.
• W4387396720 creator A5013335698 @default.
• W4387396720 creator A5014243211 @default.
• W4387396720 creator A5029119143 @default.
• W4387396720 creator A5030863775 @default.
• W4387396720 creator A5042176884 @default.
• W4387396720 creator A5061203513 @default.
• W4387396720 creator A5086396081 @default.
• W4387396720 date "2023-10-01" @default.
• W4387396720 modified "2023-10-07" @default.
• W4387396720 title "SHORT- AND LONG-TERM TESTOSTERONE TREATMENT INDUCE REVERSIBLE SUBFERTILITY IN A MOUSE MODEL OF GENDER-AFFIRMING HORMONE THERAPY" @default.
• W4387396720 doi "https://doi.org/10.1016/j.fertnstert.2023.08.095" @default.
• W4387396720 hasPublicationYear "2023" @default.
• W4387396720 type Work @default.
• W4387396720 citedByCount "0" @default.
• W4387396720 crossrefType "journal-article" @default.
• W4387396720 hasAuthorship W4387396720A5013335698 @default.
• W4387396720 hasAuthorship W4387396720A5014243211 @default.
• W4387396720 hasAuthorship W4387396720A5029119143 @default.
• W4387396720 hasAuthorship W4387396720A5030863775 @default.
• W4387396720 hasAuthorship W4387396720A5042176884 @default.
• W4387396720 hasAuthorship W4387396720A5061203513 @default.
• W4387396720 hasAuthorship W4387396720A5086396081 @default.
• W4387396720 hasBestOaLocation W43873967201 @default.
• W4387396720 hasConcept C112672928 @default.
• W4387396720 hasConcept C126322002 @default.
• W4387396720 hasConcept C134018914 @default.
• W4387396720 hasConcept C16685009 @default.
• W4387396720 hasConcept C1998276 @default.
• W4387396720 hasConcept C2779234561 @default.
• W4387396720 hasConcept C2779279991 @default.
• W4387396720 hasConcept C2779429622 @default.
• W4387396720 hasConcept C42407357 @default.
• W4387396720 hasConcept C46973012 @default.
• W4387396720 hasConcept C54355233 @default.
• W4387396720 hasConcept C6557445 @default.
• W4387396720 hasConcept C71924100 @default.
• W4387396720 hasConcept C86803240 @default.
• W4387396720 hasConceptScore W4387396720C112672928 @default.
• W4387396720 hasConceptScore W4387396720C126322002 @default.
• W4387396720 hasConceptScore W4387396720C134018914 @default.
• W4387396720 hasConceptScore W4387396720C16685009 @default.
• W4387396720 hasConceptScore W4387396720C1998276 @default.
• W4387396720 hasConceptScore W4387396720C2779234561 @default.
• W4387396720 hasConceptScore W4387396720C2779279991 @default.
• W4387396720 hasConceptScore W4387396720C2779429622 @default.
• W4387396720 hasConceptScore W4387396720C42407357 @default.
• W4387396720 hasConceptScore W4387396720C46973012 @default.
• W4387396720 hasConceptScore W4387396720C54355233 @default.
• W4387396720 hasConceptScore W4387396720C6557445 @default.
• W4387396720 hasConceptScore W4387396720C71924100 @default.
• W4387396720 hasConceptScore W4387396720C86803240 @default.
• W4387396720 hasIssue "4" @default.
• W4387396720 hasLocation W43873967201 @default.
• W4387396720 hasOpenAccess W4387396720 @default.
• W4387396720 hasPrimaryLocation W43873967201 @default.
• W4387396720 hasRelatedWork W1984669348 @default.
• W4387396720 hasRelatedWork W2021228302 @default.
• W4387396720 hasRelatedWork W2037508189 @default.
• W4387396720 hasRelatedWork W2063828562 @default.
• W4387396720 hasRelatedWork W2068085250 @default.
• W4387396720 hasRelatedWork W2080340812 @default.
• W4387396720 hasRelatedWork W2087314914 @default.
• W4387396720 hasRelatedWork W2171445355 @default.
• W4387396720 hasRelatedWork W2364208842 @default.
• W4387396720 hasRelatedWork W2414171534 @default.
• W4387396720 hasVolume "120" @default.
• W4387396720 isParatext "false" @default.
• W4387396720 isRetracted "false" @default.
• W4387396720 workType "article" @default.