FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387396722> ?p ?o ?g. }

• W4387396722 endingPage "e19" @default.
• W4387396722 startingPage "e19" @default.
• W4387396722 abstract "Previous studies comparing the effects of Granulocyte Colony Stimulating Factor (GCSF) and Platelet Rich Plasma (PRP) on the outcomes of frozen embryo transfer (FET) have produced conflicting results due to the lack of formal randomized controlled trials (RCTs). This study aimed to investigate the impact of intrauterine infusion of GCSF and PRP on the clinical pregnancy rate and outcomes in women undergoing FET, as well as the effect of these interventions on the implantation rate, transvaginal ultrasound (TVUS) and Doppler findings, and histological assessment of the endometrium. This RCT included 390 women randomized equally to three arms receiving either 300 mcg GCSF, 1 ml PRP, or saline. The intervention was slowly infused into the uterine cavity using the intrauterine insemination catheter under ultrasound guidance. All women received conventional hormonal therapy before the FET cycle. The endometrium was evaluated by TVUS, Doppler, and histological assessment in both natural and intervention cycles. Before the transfer, a group of embryos were genetically tested using NGS techniques. The clinical pregnancy rate was determined by the presence of fetal heartbeat by TVUS after 6 weeks of embryo transfer. Pregnancy outcomes were followed up after pregnancy confirmations. The clinical pregnancy rate did not differ significantly across the study arms (50.4% in GCSF, 51.2% in PRP, and 45.8% in placebo; P=0.66). PRP administration resulted in a significant improvement in endometrial vascularity compared to placebo (P=0.003). However, this change did not affect the clinical pregnancy rate, and all other endometrial variables showed no significant differences between the study arms. The live birth rate was comparable within the arms (72.5% in GCSF, 75.6% in PRP, and 76.9% in placebo; P=0.897). The pregnancy rate and outcome were still statistically non-significant when subgroup analyses were performed in women who had thin endometrium (<7 mm), women classified as poor-responders (antimullerian hormone <1), women who underwent preimplantation genetic screening using next-generation sequencing, or women who had recurrent implantation failure (≥3 times). This study demonstrates that neither GCSF nor PRP has an impact on the clinical pregnancy rate or pregnancy outcomes. Although PRP administration resulted in a significant improvement in endometrial vascularity, it did not affect the clinical pregnancy rate. Both interventions had comparable results with the infusion of saline." @default.
• W4387396722 created "2023-10-07" @default.
• W4387396722 creator A5004681616 @default.
• W4387396722 creator A5061254710 @default.
• W4387396722 creator A5070506989 @default.
• W4387396722 creator A5093015483 @default.
• W4387396722 creator A5093015484 @default.
• W4387396722 date "2023-10-01" @default.
• W4387396722 modified "2023-10-07" @default.
• W4387396722 title "PLATELET-RICH PLASMA AND COLONY-STIMULATING FACTOR ARE NON SUPERIOR TO PLACEBO IN IMPROVING ENDOMETRIAL QUALITY DURING FROZEN EMBRYO ICSI CYCLES - A DOUBLE-BLIND RCT" @default.
• W4387396722 doi "https://doi.org/10.1016/j.fertnstert.2023.08.104" @default.
• W4387396722 hasPublicationYear "2023" @default.
• W4387396722 type Work @default.
• W4387396722 citedByCount "0" @default.
• W4387396722 crossrefType "journal-article" @default.
• W4387396722 hasAuthorship W4387396722A5004681616 @default.
• W4387396722 hasAuthorship W4387396722A5061254710 @default.
• W4387396722 hasAuthorship W4387396722A5070506989 @default.
• W4387396722 hasAuthorship W4387396722A5093015483 @default.
• W4387396722 hasAuthorship W4387396722A5093015484 @default.
• W4387396722 hasBestOaLocation W43873967221 @default.
• W4387396722 hasConcept C126322002 @default.
• W4387396722 hasConcept C126894567 @default.
• W4387396722 hasConcept C131872663 @default.
• W4387396722 hasConcept C142724271 @default.
• W4387396722 hasConcept C160099875 @default.
• W4387396722 hasConcept C168563851 @default.
• W4387396722 hasConcept C204787440 @default.
• W4387396722 hasConcept C27081682 @default.
• W4387396722 hasConcept C2776537878 @default.
• W4387396722 hasConcept C2778279030 @default.
• W4387396722 hasConcept C2779234561 @default.
• W4387396722 hasConcept C2779742232 @default.
• W4387396722 hasConcept C29456083 @default.
• W4387396722 hasConcept C54355233 @default.
• W4387396722 hasConcept C71924100 @default.
• W4387396722 hasConcept C86803240 @default.
• W4387396722 hasConceptScore W4387396722C126322002 @default.
• W4387396722 hasConceptScore W4387396722C126894567 @default.
• W4387396722 hasConceptScore W4387396722C131872663 @default.
• W4387396722 hasConceptScore W4387396722C142724271 @default.
• W4387396722 hasConceptScore W4387396722C160099875 @default.
• W4387396722 hasConceptScore W4387396722C168563851 @default.
• W4387396722 hasConceptScore W4387396722C204787440 @default.
• W4387396722 hasConceptScore W4387396722C27081682 @default.
• W4387396722 hasConceptScore W4387396722C2776537878 @default.
• W4387396722 hasConceptScore W4387396722C2778279030 @default.
• W4387396722 hasConceptScore W4387396722C2779234561 @default.
• W4387396722 hasConceptScore W4387396722C2779742232 @default.
• W4387396722 hasConceptScore W4387396722C29456083 @default.
• W4387396722 hasConceptScore W4387396722C54355233 @default.
• W4387396722 hasConceptScore W4387396722C71924100 @default.
• W4387396722 hasConceptScore W4387396722C86803240 @default.
• W4387396722 hasIssue "4" @default.
• W4387396722 hasLocation W43873967221 @default.
• W4387396722 hasOpenAccess W4387396722 @default.
• W4387396722 hasPrimaryLocation W43873967221 @default.
• W4387396722 hasRelatedWork W1900961353 @default.
• W4387396722 hasRelatedWork W2085604483 @default.
• W4387396722 hasRelatedWork W2255266205 @default.
• W4387396722 hasRelatedWork W2364888713 @default.
• W4387396722 hasRelatedWork W3014048110 @default.
• W4387396722 hasRelatedWork W4292064775 @default.
• W4387396722 hasRelatedWork W4294752176 @default.
• W4387396722 hasRelatedWork W4307393785 @default.
• W4387396722 hasRelatedWork W4309387083 @default.
• W4387396722 hasRelatedWork W4377094418 @default.
• W4387396722 hasVolume "120" @default.
• W4387396722 isParatext "false" @default.
• W4387396722 isRetracted "false" @default.
• W4387396722 workType "article" @default.