FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387396852> ?p ?o ?g. }

• W4387396852 abstract "Recent reports have uncovered a HOXB13 variant (X285K) predisposing to prostate cancer in men of West African ancestry. The clinical relevance and protein function associated with this inherited variant are unknown.To determine the clinical relevance of HOXB13 (X285K) in comparison with HOXB13 (G84E) and BRCA2 pathogenic/likely pathogenic (P/LP) variants, and to elucidate the oncogenic mechanisms of the X285K protein.Real-world data were collected from 21,393 men with prostate cancer undergoing genetic testing from 2019 to 2022, and in vitro cell-line models were established for the evaluation of oncogenic functions associated with the X285K protein.Genetic testing results were compared among patient groups according to self-reported race/ethnicity, Gleason scores, and American Joint Committee on Cancer stages using the exact test. Oncogenic functions of X285K were evaluated by RNA sequencing, chromatin immunoprecipitation sequencing, and Western blot analyses.HOXB13 (X285K) was significantly enriched in self-reported Black (1.01%) versus White (0.01%) patients. We observed a trend of more aggressive disease in the HOXB13 (X285K) and BRCA2 P/LP carriers than in the HOXB13 (G84E) carriers. Replacement of the wild-type HOXB13 protein with the X285K protein resulted in a gain of an E2F/MYC signature, validated by the elevated expression of cyclin B1 and c-Myc, without affecting the androgen response signature. Elevated expression of cyclin B1 and c-Myc was explained by enhanced binding of the X285K protein to the promoters and enhancers of these genes. The limitations of the study are the lack of complete clinical outcome data for all patients studied and the use of a single cell line in the functional analysis.HOXB13 (X285K) is significantly enriched in self-reported Black patients, and X285K carriers detected in the real-world clinical setting have aggressive prostate cancer features similar to the BRCA2 carriers. Functional studies revealed a unique gain-of-function oncogenic mechanism of X285K protein in regulating E2F/MYC signatures.The HOXB13 (X285K) variant is clinically and functionally linked to aggressive prostate cancer, supporting genetic testing for X285K in Black men and early disease screening of carriers of this variant." @default.
• W4387396852 created "2023-10-07" @default.
• W4387396852 creator A5000924535 @default.
• W4387396852 creator A5003631861 @default.
• W4387396852 creator A5018755246 @default.
• W4387396852 creator A5025557022 @default.
• W4387396852 creator A5032695297 @default.
• W4387396852 creator A5043640443 @default.
• W4387396852 creator A5057048206 @default.
• W4387396852 creator A5068348417 @default.
• W4387396852 creator A5068783800 @default.
• W4387396852 creator A5075880342 @default.
• W4387396852 creator A5077552075 @default.
• W4387396852 creator A5080102032 @default.
• W4387396852 date "2023-10-01" @default.
• W4387396852 modified "2023-10-14" @default.
• W4387396852 title "Clinical and Functional Analyses of an African-ancestry Gain-of-function HOXB13 Variant Implicated in Aggressive Prostate Cancer" @default.
• W4387396852 cites W1951061860 @default.
• W4387396852 cites W1999343166 @default.
• W4387396852 cites W2047936642 @default.
• W4387396852 cites W2063908773 @default.
• W4387396852 cites W2096151138 @default.
• W4387396852 cites W2178232667 @default.
• W4387396852 cites W2462985846 @default.
• W4387396852 cites W2529359415 @default.
• W4387396852 cites W2586694861 @default.
• W4387396852 cites W2612091911 @default.
• W4387396852 cites W2806280499 @default.
• W4387396852 cites W2889764312 @default.
• W4387396852 cites W2904868717 @default.
• W4387396852 cites W2912387879 @default.
• W4387396852 cites W2939637368 @default.
• W4387396852 cites W2953710931 @default.
• W4387396852 cites W3006377533 @default.
• W4387396852 cites W3006796014 @default.
• W4387396852 cites W3014963373 @default.
• W4387396852 cites W3032510750 @default.
• W4387396852 cites W3035162230 @default.
• W4387396852 cites W3108584718 @default.
• W4387396852 cites W3115151307 @default.
• W4387396852 cites W3159671141 @default.
• W4387396852 cites W3207297220 @default.
• W4387396852 cites W3212118093 @default.
• W4387396852 cites W4200565535 @default.
• W4387396852 cites W4206592801 @default.
• W4387396852 cites W4214632803 @default.
• W4387396852 cites W4224315257 @default.
• W4387396852 cites W4226529881 @default.
• W4387396852 cites W4285802185 @default.
• W4387396852 doi "https://doi.org/10.1016/j.euo.2023.09.012" @default.
• W4387396852 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37806842" @default.
• W4387396852 hasPublicationYear "2023" @default.
• W4387396852 type Work @default.
• W4387396852 citedByCount "0" @default.
• W4387396852 crossrefType "journal-article" @default.
• W4387396852 hasAuthorship W4387396852A5000924535 @default.
• W4387396852 hasAuthorship W4387396852A5003631861 @default.
• W4387396852 hasAuthorship W4387396852A5018755246 @default.
• W4387396852 hasAuthorship W4387396852A5025557022 @default.
• W4387396852 hasAuthorship W4387396852A5032695297 @default.
• W4387396852 hasAuthorship W4387396852A5043640443 @default.
• W4387396852 hasAuthorship W4387396852A5057048206 @default.
• W4387396852 hasAuthorship W4387396852A5068348417 @default.
• W4387396852 hasAuthorship W4387396852A5068783800 @default.
• W4387396852 hasAuthorship W4387396852A5075880342 @default.
• W4387396852 hasAuthorship W4387396852A5077552075 @default.
• W4387396852 hasAuthorship W4387396852A5080102032 @default.
• W4387396852 hasConcept C101762097 @default.
• W4387396852 hasConcept C104317684 @default.
• W4387396852 hasConcept C121608353 @default.
• W4387396852 hasConcept C126322002 @default.
• W4387396852 hasConcept C143998085 @default.
• W4387396852 hasConcept C150194340 @default.
• W4387396852 hasConcept C2780192828 @default.
• W4387396852 hasConcept C502942594 @default.
• W4387396852 hasConcept C54355233 @default.
• W4387396852 hasConcept C63363279 @default.
• W4387396852 hasConcept C71924100 @default.
• W4387396852 hasConcept C86803240 @default.
• W4387396852 hasConceptScore W4387396852C101762097 @default.
• W4387396852 hasConceptScore W4387396852C104317684 @default.
• W4387396852 hasConceptScore W4387396852C121608353 @default.
• W4387396852 hasConceptScore W4387396852C126322002 @default.
• W4387396852 hasConceptScore W4387396852C143998085 @default.
• W4387396852 hasConceptScore W4387396852C150194340 @default.
• W4387396852 hasConceptScore W4387396852C2780192828 @default.
• W4387396852 hasConceptScore W4387396852C502942594 @default.
• W4387396852 hasConceptScore W4387396852C54355233 @default.
• W4387396852 hasConceptScore W4387396852C63363279 @default.
• W4387396852 hasConceptScore W4387396852C71924100 @default.
• W4387396852 hasConceptScore W4387396852C86803240 @default.
• W4387396852 hasLocation W43873968521 @default.
• W4387396852 hasLocation W43873968522 @default.
• W4387396852 hasOpenAccess W4387396852 @default.
• W4387396852 hasPrimaryLocation W43873968521 @default.
• W4387396852 hasRelatedWork W129398428 @default.
• W4387396852 hasRelatedWork W184057646 @default.
• W4387396852 hasRelatedWork W1967718992 @default.
• W4387396852 hasRelatedWork W1969771092 @default.
• W4387396852 hasRelatedWork W2007418658 @default.

• next