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• W4387397648 endingPage "246" @default.
• W4387397648 startingPage "223" @default.
• W4387397648 abstract "Gene therapy is a novel and promising therapeutic alternative that uses genes for treating a variety of illnesses, including hereditary abnormalities, cancer, some viral infections and so on. The three components that constitute gene delivery systems include a plasmid-based gene expression system that regulates a gene's function within the target cell, a gene that encodes a specific therapeutic protein, and a gene delivery system that regulates the delivery of the gene expression plasmid to a specific site within the body. The main methods for delivering genes include the use of non-viral or viral vectors. Even though viral gene carriers make good transfection vehicles, their significance as gene carriers in gene therapy is constrained by their carcinogenic and mutagenic features. Recently, non-viral gene carriers have developed significantly as substitute for viral gene carriers in genetic biotechnology. Owning to their in vivo stability, high gene encapsulation, and enhanced transfection effectiveness, cationic polymers (e.g. chitosan) were widely exploited as alternative gene carriers for gene delivery. Chitosan, when used as a vehicle for gene transfer, appear not hazardous. By overcoming the systemic hurdles to gene delivery, chitosan appears to have outstanding physicochemical characteristics that are advantageous for nucleic acid transport. When chitosan interacts electrostatically with nucleic acids, it easily forms complexes, microspheres, or nanoparticles. This chapter presents recent advances on role of chitosan in gene delivery and therapy." @default.
• W4387397648 created "2023-10-07" @default.
• W4387397648 creator A5086557356 @default.
• W4387397648 date "2023-10-05" @default.
• W4387397648 modified "2023-10-07" @default.
• W4387397648 title "Utilization of Chitosan for Gene Delivery" @default.
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