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- W4387397810 abstract "Biocatalytic processes are highly selective and specific. However, their utility is limited by the comparatively narrow scope of enzyme‐catalysed transformations. To expand product scope, we are developing biocompatible processes that combine biocatalytic reactions with chemo‐catalysis in single‐flask processes. Here, we show that a chemocatalysed Pictet‐Spengler annulation can be interfaced with biocatalysed alcohol oxidation. This two‐step, one‐pot cascade reaction converts tyramine and aliphatic alcohols to tetrahydroisoquinoline alkaloids in aqueous buffer at mild pH. Tryptamine derivatives are also efficiently converted to tryptolines. Optimization of stoichiometry, pH, reaction time, and whole‐cell catalyst deliver the tetrahydroisoquinolines and tryptolines in >90% and >40% isolated yield, respectively, with excellent regioselectivity." @default.
- W4387397810 created "2023-10-07" @default.
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- W4387397810 date "2023-10-06" @default.
- W4387397810 modified "2023-10-08" @default.
- W4387397810 title "Interfacing Whole Cell Biocatalysis with a Biocompatible Pictet‐Spengler Reaction for One‐Pot Syntheses of Tetrahydroisoquiolines and Tryptolines" @default.
- W4387397810 doi "https://doi.org/10.1002/cbic.202300464" @default.
- W4387397810 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37801398" @default.
- W4387397810 hasPublicationYear "2023" @default.
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