FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387398445> ?p ?o ?g. }

• W4387398445 abstract "Removing excessively produced cytokines is of paramount significance in blood purification therapy for hypercytokinemia-associated diseases. In this study, we devised a conduit that is modified with nanobodies (Nb) and incorporates static mixers (Nb-SMC) to eliminate surplus cytokines from the bloodstream. The low-pressure-drop (LPD) static mixer, with each unit featuring two 90°-crossed blades, was strategically arranged in a tessellated pattern on the inner wall of the conduit to induce turbulent mixing effects during the flow of blood. This arrangement enhances mass transfer and molecular diffusion, thereby assisting in the identification and elimination of cytokines. By utilizing computational fluid dynamics (CFD) studies, the Nb-SMC was rationally designed and prepared, ensuring an optimal interval between two mixer units (H/G = 2.5). The resulting Nb-SMC exhibited a remarkable selective clearance of IL-17A, reaching up to 85 %. Additionally, the process of Nb immobilization could be adjusted to achieve the simultaneous removal of multiple cytokines from the bloodstream. Notably, our Nb-SMC displayed good blood compatibility without potential adverse effects on the composition of human blood. As the sole documented static mixer-integrated conduit capable of selectively eliminating cytokines at their physiological concentrations, it holds promise in the clinical potential for hypercytokinemia in high-risk patients. STATEMENT OF SIGNIFICANCE: High-efficient cytokines removal in critical care still remains a challenge. The conduit technique we proposed here is a brand-new strategy for cytokines removal in blood purification therapy. On the one hand, nanobody endows the conduit with specific recognition of cytokine, on the other hand, the build-in static mixer enhances the diffusion of antigenic cytokine to the ligand. The combination of these two has jointly achieved the efficient and specific removal of cytokine. This innovative material is the only reported artificial biomaterial capable of selectively eliminating multiple cytokines under conditions close to clinical practice. It has the potential to improve outcomes for patients with hypercytokinemia and reduce the risk of adverse events associated with current treatment modalities." @default.
• W4387398445 created "2023-10-07" @default.
• W4387398445 creator A5003315472 @default.
• W4387398445 creator A5021202757 @default.
• W4387398445 creator A5044931490 @default.
• W4387398445 creator A5062711588 @default.
• W4387398445 creator A5091515136 @default.
• W4387398445 date "2023-10-01" @default.
• W4387398445 modified "2023-10-14" @default.
• W4387398445 title "Nanobody-functionalized conduit with built-in static mixer for specific elimination of cytokines in hemoperfusion" @default.
• W4387398445 cites W1794798852 @default.
• W4387398445 cites W1978240589 @default.
• W4387398445 cites W1991491479 @default.
• W4387398445 cites W2015858036 @default.
• W4387398445 cites W2017827273 @default.
• W4387398445 cites W2027443935 @default.
• W4387398445 cites W2032105397 @default.
• W4387398445 cites W2062050189 @default.
• W4387398445 cites W2062681614 @default.
• W4387398445 cites W2085311751 @default.
• W4387398445 cites W2085995657 @default.
• W4387398445 cites W2103836777 @default.
• W4387398445 cites W2120038815 @default.
• W4387398445 cites W2120173324 @default.
• W4387398445 cites W2121912128 @default.
• W4387398445 cites W2131007035 @default.
• W4387398445 cites W2166779888 @default.
• W4387398445 cites W2169610187 @default.
• W4387398445 cites W2193034607 @default.
• W4387398445 cites W2243050331 @default.
• W4387398445 cites W2262915231 @default.
• W4387398445 cites W2614738659 @default.
• W4387398445 cites W2617620062 @default.
• W4387398445 cites W2620252006 @default.
• W4387398445 cites W2626909594 @default.
• W4387398445 cites W2733732377 @default.
• W4387398445 cites W2755189032 @default.
• W4387398445 cites W2797096615 @default.
• W4387398445 cites W2862485754 @default.
• W4387398445 cites W2883796193 @default.
• W4387398445 cites W2899287943 @default.
• W4387398445 cites W2942853781 @default.
• W4387398445 cites W2945686759 @default.
• W4387398445 cites W2947461022 @default.
• W4387398445 cites W2964292909 @default.
• W4387398445 cites W2985640274 @default.
• W4387398445 cites W2987094402 @default.
• W4387398445 cites W3008479986 @default.
• W4387398445 cites W3012186724 @default.
• W4387398445 cites W3014238425 @default.
• W4387398445 cites W3034979134 @default.
• W4387398445 cites W3048515223 @default.
• W4387398445 cites W3086999121 @default.
• W4387398445 cites W3108156557 @default.
• W4387398445 cites W3150730956 @default.
• W4387398445 cites W3183751531 @default.
• W4387398445 cites W3185696629 @default.
• W4387398445 cites W3194135293 @default.
• W4387398445 cites W3207681600 @default.
• W4387398445 cites W4205549900 @default.
• W4387398445 cites W4210563724 @default.
• W4387398445 cites W4281298887 @default.
• W4387398445 cites W4289519421 @default.
• W4387398445 cites W4290653589 @default.
• W4387398445 cites W4311824994 @default.
• W4387398445 cites W4315778043 @default.
• W4387398445 cites W4320918999 @default.
• W4387398445 doi "https://doi.org/10.1016/j.actbio.2023.09.050" @default.
• W4387398445 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37806373" @default.
• W4387398445 hasPublicationYear "2023" @default.
• W4387398445 type Work @default.
• W4387398445 citedByCount "0" @default.
• W4387398445 crossrefType "journal-article" @default.
• W4387398445 hasAuthorship W4387398445A5003315472 @default.
• W4387398445 hasAuthorship W4387398445A5021202757 @default.
• W4387398445 hasAuthorship W4387398445A5044931490 @default.
• W4387398445 hasAuthorship W4387398445A5062711588 @default.
• W4387398445 hasAuthorship W4387398445A5091515136 @default.
• W4387398445 hasBestOaLocation W43873984451 @default.
• W4387398445 hasConcept C127413603 @default.
• W4387398445 hasConcept C136229726 @default.
• W4387398445 hasConcept C141071460 @default.
• W4387398445 hasConcept C164027704 @default.
• W4387398445 hasConcept C192562407 @default.
• W4387398445 hasConcept C203014093 @default.
• W4387398445 hasConcept C2776914184 @default.
• W4387398445 hasConcept C2778063415 @default.
• W4387398445 hasConcept C2778690821 @default.
• W4387398445 hasConcept C2781123077 @default.
• W4387398445 hasConcept C71924100 @default.
• W4387398445 hasConcept C78519656 @default.
• W4387398445 hasConcept C89836073 @default.
• W4387398445 hasConceptScore W4387398445C127413603 @default.
• W4387398445 hasConceptScore W4387398445C136229726 @default.
• W4387398445 hasConceptScore W4387398445C141071460 @default.
• W4387398445 hasConceptScore W4387398445C164027704 @default.
• W4387398445 hasConceptScore W4387398445C192562407 @default.
• W4387398445 hasConceptScore W4387398445C203014093 @default.
• W4387398445 hasConceptScore W4387398445C2776914184 @default.
• W4387398445 hasConceptScore W4387398445C2778063415 @default.

• next