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- W4387398510 endingPage "154853" @default.
- W4387398510 startingPage "154853" @default.
- W4387398510 abstract "Fibrosis is a pathological wound-healing mechanism that results from the overactivation of fibroblasts. Fibrosis can become obstructive and deleterious during regeneration of various body tissues including cardiac muscle. This ultimately results in the development of cardiac fibrosis, characterized by an excessive buildup of extracellular matrix proteins. Thus, it could lead to arrhythmias and heart failure which creates a leading public health burden worldwide. As for miRNAs, they are small non-coding RNAs with great potential for diagnostic and therapeutic purposes. Mounting evidence indicates that miRNAs are involved in the deregulation of tissue homeostasis during myocardial fibrosis. For instance, miRNAs that are implicated in the regulation of TGF-beta signaling pathway have been reported to be significantly altered in myocardial fibrosis. Accordingly, in this comprehensive review, we discuss and highlight recent available data on the role of miRNAs during myocardial fibrosis, providing valuable insights into the miRNA modulation of cardiac fibrosis and miRNAs targets that can be used in the future therapeutic interventions to cardiac fibrosis." @default.
- W4387398510 created "2023-10-07" @default.
- W4387398510 creator A5063378973 @default.
- W4387398510 creator A5092588673 @default.
- W4387398510 creator A5093015810 @default.
- W4387398510 creator A5093015811 @default.
- W4387398510 date "2023-10-01" @default.
- W4387398510 modified "2023-10-07" @default.
- W4387398510 title "MicroRNAs and Cardiac Fibrosis: A Comprehensive Update on Mechanisms and Consequences" @default.
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