Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387398524> ?p ?o ?g. }
Showing items 1 to 49 of
49
with 100 items per page.
- W4387398524 abstract "Prophylactic cranial irradiation (PCI) is considered an important technological advance made in oncology in an effort to reduce the incidence of brain metastases (BM) and improve overall survival (OS) of patients with small cell lung cancer (SCLC). Although it is often reported that PCI improves the therapeutic potential in limited-stage (LS) SCLC, no randomised trial has ever conclusively confirmed this. Nevertheless, PCI has been considered the standard of care for LS-SCLC since the late 1990s. The data supporting the use of PCI in LS-SCLC are based on an analysis of work performed prior to the current approach to staging [brain magnetic resonance imaging (MRI), positron emission tomography (PET)/computed tomography (CT)]. The evidence for the rationale and feasibility of this approach in the modern diagnostic era should be demonstrated. The situation with extensive stage (ES) SCLC is seemingly easier because, unlike LS-SCLC, we have data from two randomised trials. Unfortunately, their results are in direct conflict with each other. Although it is generally assumed that good control of brain disease leads to better quality of life, this has never been prospectively demonstrated. In fact, PCI is associated not only with increased treatment costs and some patient discomfort, but also with non-negligible potential toxicity. For this reason, efforts have been made to preserve cognitive function by sparing the hippocampus. This concept is called hippocampal avoidance. The optimal fractionation regimen is currently less controversial than the optimal integration of PCI into the treatment algorithm. A dose of 25 Gy administered in 10 fractions should remain the standard for the eventual use of PCI in patients with SCLC. In summary, PCI is not a conditio sine qua non in any indication. Neither in patients with LS-SCLC nor in patients with ES-SCLC has a clear improvement in OS been demonstrated at follow-up using current imaging modalities." @default.
- W4387398524 created "2023-10-07" @default.
- W4387398524 creator A5088630425 @default.
- W4387398524 date "2023-09-19" @default.
- W4387398524 modified "2023-10-07" @default.
- W4387398524 title "What is the current role of prophylactic cranial irradiation in the treatment algorithm for small cell lung cancer?" @default.
- W4387398524 doi "https://doi.org/10.5603/rpor.97432" @default.
- W4387398524 hasPublicationYear "2023" @default.
- W4387398524 type Work @default.
- W4387398524 citedByCount "0" @default.
- W4387398524 crossrefType "journal-article" @default.
- W4387398524 hasAuthorship W4387398524A5088630425 @default.
- W4387398524 hasBestOaLocation W43873985241 @default.
- W4387398524 hasConcept C126322002 @default.
- W4387398524 hasConcept C126838900 @default.
- W4387398524 hasConcept C143998085 @default.
- W4387398524 hasConcept C2775842073 @default.
- W4387398524 hasConcept C2776256026 @default.
- W4387398524 hasConcept C2779562246 @default.
- W4387398524 hasConcept C2989005 @default.
- W4387398524 hasConcept C45393284 @default.
- W4387398524 hasConcept C500558357 @default.
- W4387398524 hasConcept C71924100 @default.
- W4387398524 hasConceptScore W4387398524C126322002 @default.
- W4387398524 hasConceptScore W4387398524C126838900 @default.
- W4387398524 hasConceptScore W4387398524C143998085 @default.
- W4387398524 hasConceptScore W4387398524C2775842073 @default.
- W4387398524 hasConceptScore W4387398524C2776256026 @default.
- W4387398524 hasConceptScore W4387398524C2779562246 @default.
- W4387398524 hasConceptScore W4387398524C2989005 @default.
- W4387398524 hasConceptScore W4387398524C45393284 @default.
- W4387398524 hasConceptScore W4387398524C500558357 @default.
- W4387398524 hasConceptScore W4387398524C71924100 @default.
- W4387398524 hasLocation W43873985241 @default.
- W4387398524 hasOpenAccess W4387398524 @default.
- W4387398524 hasPrimaryLocation W43873985241 @default.
- W4387398524 hasRelatedWork W1982203825 @default.
- W4387398524 hasRelatedWork W1989308867 @default.
- W4387398524 hasRelatedWork W1994546669 @default.
- W4387398524 hasRelatedWork W2001663274 @default.
- W4387398524 hasRelatedWork W2017836189 @default.
- W4387398524 hasRelatedWork W2048847191 @default.
- W4387398524 hasRelatedWork W2089171902 @default.
- W4387398524 hasRelatedWork W2134044915 @default.
- W4387398524 hasRelatedWork W2767645483 @default.
- W4387398524 hasRelatedWork W3094743317 @default.
- W4387398524 isParatext "false" @default.
- W4387398524 isRetracted "false" @default.
- W4387398524 workType "article" @default.