Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387400654> ?p ?o ?g. }
- W4387400654 endingPage "2055" @default.
- W4387400654 startingPage "2055" @default.
- W4387400654 abstract "A cure for HIV-1 (HIV) remains unrealized due to a reservoir of latently infected cells that persist during antiretroviral therapy (ART), with reservoir size associated with adverse health outcomes and inversely with time to viral rebound upon ART cessation. Once established during ART, the HIV reservoir decays minimally over time; thus, understanding factors that impact the size of the HIV reservoir near its establishment is key to improving the health of people living with HIV and for the development of novel cure strategies. Yet, to date, few correlates of HIV reservoir size have been identified, particularly in pediatric populations. Here, we employed a cross-subtype intact proviral DNA assay (CS-IPDA) to quantify HIV provirus between one- and two-years post-ART initiation in a cohort of Kenyan children (n = 72), which had a median of 99 intact (range: 0–2469), 1340 defective (range: 172–3.84 × 104), and 1729 total (range: 178–5.11 × 104) HIV proviral copies per one million T cells. Additionally, pre-ART plasma was tested for HIV Env-specific antibody-dependent cellular cytotoxicity (ADCC) activity. We found that pre-ART gp120-specific ADCC activity inversely correlated with defective provirus levels (n = 68, r = −0.285, p = 0.0214) but not the intact reservoir (n = 68, r = −0.0321, p-value = 0.800). Pre-ART gp41-specific ADCC did not significantly correlate with either proviral population (n = 68; intact: r = −0.0512, p-value = 0.686; defective: r = −0.109, p-value = 0.389). This suggests specific host immune factors prior to ART initiation can impact proviruses that persist during ART." @default.
- W4387400654 created "2023-10-07" @default.
- W4387400654 creator A5003676309 @default.
- W4387400654 creator A5007081009 @default.
- W4387400654 creator A5043140586 @default.
- W4387400654 creator A5048323364 @default.
- W4387400654 creator A5050646425 @default.
- W4387400654 creator A5061366174 @default.
- W4387400654 creator A5075328638 @default.
- W4387400654 creator A5084874518 @default.
- W4387400654 creator A5092926656 @default.
- W4387400654 creator A5093016354 @default.
- W4387400654 date "2023-10-06" @default.
- W4387400654 modified "2023-10-07" @default.
- W4387400654 title "Higher HIV-1 Env gp120-Specific Antibody-Dependent Cellular Cytotoxicity (ADCC) Activity Is Associated with Lower Levels of Defective HIV-1 Provirus" @default.
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